FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116622975> ?p ?o ?g. }

• W3116622975 endingPage "102957" @default.
• W3116622975 startingPage "102957" @default.
• W3116622975 abstract "Plant metabolites represent complex chemical system, which renders it difficult to clarify the chemical composition by conventional liquid chromatography/mass spectrometry (LC/MS) due to the limited selectivity and peak capacity. The rhizomes of Atractylodes macrocephala have been utilized as a traditional Chinese medicine Atractylodis Macrocephalae Rhizoma (Bai-Zhu), and have been reported containing multiple categories of plant metabolites. Targeting the multicomponents from A. macrocephala, an integral approach by offline two-dimensional liquid chromatography/ion mobility quadrupole time-of-flight mass spectrometry (2D-LC/IM-QTOF-MS) was established and validated. By configuring an XBridge Amide column of Hydrophilic Interaction Chromatography and an Atlantis Premier BEH C18AX column of mixed ion exchange and reversed-phase modes, the established 2D-LC/IM-QTOF-MS system showed high orthogonality up to 0.91. Dimension-enhanced, data-independent high-definition MSE (HDMSE) in the positive ESI mode was conducted on a Vion IM-QTOF mass spectrometer, and its hyphenation to offline 2D-LC could enable the four-dimensional separation (each dimension in 2D-LC, IM, and MS). Particularly, HDMSE facilitated the acquisition of high-definition MS1 and MS2 spectra. In-house library-driven computational peak annotation by the bioinformatics platform UNIFI could efficiently process and annotate the HDMSE data for the structural elucidation. By integrating reference compounds comparison, we could identify or tentatively characterize 251 components from A. macrocephala (including 115 sesquiterpenoids, 90 polyacetylenes, 11 flavonoids, 9 benzoquinones, 12 coumarins, and 14 others), which indicated large improvement in identifying those minor plant components, compared with the conventional LC/MS approach. Conclusively, offline 2D-LC/IM-QTOF-HDMSE in combination with computational data interpretation proves to be powerful facilitating the in-depth multicomponent characterization of herbal medicine." @default.
• W3116622975 created "2021-01-05" @default.
• W3116622975 creator A5004732989 @default.
• W3116622975 creator A5016586562 @default.
• W3116622975 creator A5033680548 @default.
• W3116622975 creator A5033684035 @default.
• W3116622975 creator A5053717233 @default.
• W3116622975 creator A5057723713 @default.
• W3116622975 creator A5059685663 @default.
• W3116622975 creator A5066546795 @default.
• W3116622975 creator A5078071191 @default.
• W3116622975 creator A5078126271 @default.
• W3116622975 date "2021-02-01" @default.
• W3116622975 modified "2023-10-16" @default.
• W3116622975 title "A four-dimensional separation approach by offline 2D-LC/IM-TOF-MS in combination with database-driven computational peak annotation facilitating the in-depth characterization of the multicomponents from Atractylodis Macrocephalae Rhizoma (Atractylodes macrocephala)" @default.
• W3116622975 cites W1219352183 @default.
• W3116622975 cites W1972094813 @default.
• W3116622975 cites W1978235493 @default.
• W3116622975 cites W1997947367 @default.
• W3116622975 cites W1999349354 @default.
• W3116622975 cites W2005369156 @default.
• W3116622975 cites W2071321408 @default.
• W3116622975 cites W2093107063 @default.
• W3116622975 cites W2146066642 @default.
• W3116622975 cites W2149883808 @default.
• W3116622975 cites W2222506372 @default.
• W3116622975 cites W2411711535 @default.
• W3116622975 cites W2412537420 @default.
• W3116622975 cites W2419034595 @default.
• W3116622975 cites W2431941480 @default.
• W3116622975 cites W2536128108 @default.
• W3116622975 cites W2593575044 @default.
• W3116622975 cites W2609158352 @default.
• W3116622975 cites W2619968329 @default.
• W3116622975 cites W2740955623 @default.
• W3116622975 cites W2743931149 @default.
• W3116622975 cites W2762505871 @default.
• W3116622975 cites W2770742962 @default.
• W3116622975 cites W2793248883 @default.
• W3116622975 cites W2806754512 @default.
• W3116622975 cites W2887432875 @default.
• W3116622975 cites W2892973646 @default.
• W3116622975 cites W2899285383 @default.
• W3116622975 cites W2900505235 @default.
• W3116622975 cites W2914963295 @default.
• W3116622975 cites W2916887350 @default.
• W3116622975 cites W2921140780 @default.
• W3116622975 cites W2934362816 @default.
• W3116622975 cites W2949198369 @default.
• W3116622975 cites W2951933391 @default.
• W3116622975 cites W2963187513 @default.
• W3116622975 cites W2969393467 @default.
• W3116622975 cites W2970022405 @default.
• W3116622975 cites W2973593535 @default.
• W3116622975 cites W2982399331 @default.
• W3116622975 cites W2983439236 @default.
• W3116622975 cites W3013110918 @default.
• W3116622975 cites W3030279188 @default.
• W3116622975 cites W3087924343 @default.
• W3116622975 cites W3092709380 @default.
• W3116622975 cites W3012775309 @default.
• W3116622975 doi "https://doi.org/10.1016/j.arabjc.2020.102957" @default.
• W3116622975 hasPublicationYear "2021" @default.
• W3116622975 type Work @default.
• W3116622975 sameAs 3116622975 @default.
• W3116622975 citedByCount "17" @default.
• W3116622975 countsByYear W31166229752021 @default.
• W3116622975 countsByYear W31166229752022 @default.
• W3116622975 countsByYear W31166229752023 @default.
• W3116622975 crossrefType "journal-article" @default.
• W3116622975 hasAuthorship W3116622975A5004732989 @default.
• W3116622975 hasAuthorship W3116622975A5016586562 @default.
• W3116622975 hasAuthorship W3116622975A5033680548 @default.
• W3116622975 hasAuthorship W3116622975A5033684035 @default.
• W3116622975 hasAuthorship W3116622975A5053717233 @default.
• W3116622975 hasAuthorship W3116622975A5057723713 @default.
• W3116622975 hasAuthorship W3116622975A5059685663 @default.
• W3116622975 hasAuthorship W3116622975A5066546795 @default.
• W3116622975 hasAuthorship W3116622975A5078071191 @default.
• W3116622975 hasAuthorship W3116622975A5078126271 @default.
• W3116622975 hasBestOaLocation W31166229751 @default.
• W3116622975 hasConcept C113196181 @default.
• W3116622975 hasConcept C15213710 @default.
• W3116622975 hasConcept C162356407 @default.
• W3116622975 hasConcept C185592680 @default.
• W3116622975 hasConcept C3019798703 @default.
• W3116622975 hasConcept C40684141 @default.
• W3116622975 hasConcept C41008148 @default.
• W3116622975 hasConcept C43617362 @default.
• W3116622975 hasConcept C77088390 @default.
• W3116622975 hasConceptScore W3116622975C113196181 @default.
• W3116622975 hasConceptScore W3116622975C15213710 @default.
• W3116622975 hasConceptScore W3116622975C162356407 @default.
• W3116622975 hasConceptScore W3116622975C185592680 @default.
• W3116622975 hasConceptScore W3116622975C3019798703 @default.
• W3116622975 hasConceptScore W3116622975C40684141 @default.
• W3116622975 hasConceptScore W3116622975C41008148 @default.
• W3116622975 hasConceptScore W3116622975C43617362 @default.

• next