FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116641519> ?p ?o ?g. }

• W3116641519 endingPage "145381" @default.
• W3116641519 startingPage "145381" @default.
• W3116641519 abstract "We have previously found and characterized two pairs of enhancer elements, E1 and E2, in the type II collagen alpha 1 chain (COL2A1) gene. Subsequent studies have suggested that these enhancers function differently in the regulation of gene expression. For example, histone deacetylase 10 modifies only the E2 enhancer region to affect gene expression. Therefore, in this study, we aimed to clarify the transcriptional complex formed at each enhancer region by identifying transcription factors that specifically bind to each enhancer element. To this end, we used chondrocytic cell lines established using our unique silent reporter system and overexpressed candidate transcription factors in these cells. We found two transcription factors, other than the SOX trio, that directly bound to COL2A1 and regulated its expression. The first was Kruppel-like factor-4 (KLF4), which bound to the promoter proximal region, and the second was AT-rich interactive domain 5B (ARID5B) which bound to the E1 enhancer element. Further studies are needed to identify factors that specifically bind to the E2 enhancer element. In any case, our findings provide an important insight into the molecular mechanisms underlying the regulation of COL2A1. In this paper, we reevaluated the previous analysis of transcription factors involved in the regulation of COL2A1 expression." @default.
• W3116641519 created "2021-01-05" @default.
• W3116641519 creator A5071190390 @default.
• W3116641519 creator A5079555269 @default.
• W3116641519 creator A5079639326 @default.
• W3116641519 creator A5080225707 @default.
• W3116641519 date "2021-03-01" @default.
• W3116641519 modified "2023-09-28" @default.
• W3116641519 title "Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B" @default.
• W3116641519 cites W1564677921 @default.
• W3116641519 cites W1964326585 @default.
• W3116641519 cites W1973295687 @default.
• W3116641519 cites W1974932323 @default.
• W3116641519 cites W1981672525 @default.
• W3116641519 cites W1991527211 @default.
• W3116641519 cites W1993949732 @default.
• W3116641519 cites W1998621808 @default.
• W3116641519 cites W2008508028 @default.
• W3116641519 cites W2009813647 @default.
• W3116641519 cites W2022014381 @default.
• W3116641519 cites W2027918951 @default.
• W3116641519 cites W2047301497 @default.
• W3116641519 cites W2062656093 @default.
• W3116641519 cites W2081817372 @default.
• W3116641519 cites W2093791676 @default.
• W3116641519 cites W2096262427 @default.
• W3116641519 cites W2097049188 @default.
• W3116641519 cites W2101751392 @default.
• W3116641519 cites W2102047286 @default.
• W3116641519 cites W2105460274 @default.
• W3116641519 cites W2142395982 @default.
• W3116641519 cites W2146103139 @default.
• W3116641519 cites W2151708616 @default.
• W3116641519 cites W2300322889 @default.
• W3116641519 cites W2491852463 @default.
• W3116641519 cites W2504037589 @default.
• W3116641519 cites W2533324812 @default.
• W3116641519 cites W2553399865 @default.
• W3116641519 cites W2784033236 @default.
• W3116641519 cites W2940428467 @default.
• W3116641519 cites W2964695565 @default.
• W3116641519 doi "https://doi.org/10.1016/j.gene.2020.145381" @default.
• W3116641519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33383116" @default.
• W3116641519 hasPublicationYear "2021" @default.
• W3116641519 type Work @default.
• W3116641519 sameAs 3116641519 @default.
• W3116641519 citedByCount "2" @default.
• W3116641519 countsByYear W31166415192022 @default.
• W3116641519 crossrefType "journal-article" @default.
• W3116641519 hasAuthorship W3116641519A5071190390 @default.
• W3116641519 hasAuthorship W3116641519A5079555269 @default.
• W3116641519 hasAuthorship W3116641519A5079639326 @default.
• W3116641519 hasAuthorship W3116641519A5080225707 @default.
• W3116641519 hasConcept C104317684 @default.
• W3116641519 hasConcept C111936080 @default.
• W3116641519 hasConcept C138885662 @default.
• W3116641519 hasConcept C150194340 @default.
• W3116641519 hasConcept C153911025 @default.
• W3116641519 hasConcept C161733203 @default.
• W3116641519 hasConcept C165864922 @default.
• W3116641519 hasConcept C179926584 @default.
• W3116641519 hasConcept C21784809 @default.
• W3116641519 hasConcept C27153228 @default.
• W3116641519 hasConcept C2781435330 @default.
• W3116641519 hasConcept C41895202 @default.
• W3116641519 hasConcept C51183755 @default.
• W3116641519 hasConcept C54355233 @default.
• W3116641519 hasConcept C86339819 @default.
• W3116641519 hasConcept C86803240 @default.
• W3116641519 hasConcept C95444343 @default.
• W3116641519 hasConceptScore W3116641519C104317684 @default.
• W3116641519 hasConceptScore W3116641519C111936080 @default.
• W3116641519 hasConceptScore W3116641519C138885662 @default.
• W3116641519 hasConceptScore W3116641519C150194340 @default.
• W3116641519 hasConceptScore W3116641519C153911025 @default.
• W3116641519 hasConceptScore W3116641519C161733203 @default.
• W3116641519 hasConceptScore W3116641519C165864922 @default.
• W3116641519 hasConceptScore W3116641519C179926584 @default.
• W3116641519 hasConceptScore W3116641519C21784809 @default.
• W3116641519 hasConceptScore W3116641519C27153228 @default.
• W3116641519 hasConceptScore W3116641519C2781435330 @default.
• W3116641519 hasConceptScore W3116641519C41895202 @default.
• W3116641519 hasConceptScore W3116641519C51183755 @default.
• W3116641519 hasConceptScore W3116641519C54355233 @default.
• W3116641519 hasConceptScore W3116641519C86339819 @default.
• W3116641519 hasConceptScore W3116641519C86803240 @default.
• W3116641519 hasConceptScore W3116641519C95444343 @default.
• W3116641519 hasFunder F4320320912 @default.
• W3116641519 hasLocation W31166415191 @default.
• W3116641519 hasOpenAccess W3116641519 @default.
• W3116641519 hasPrimaryLocation W31166415191 @default.
• W3116641519 hasRelatedWork W1983198281 @default.
• W3116641519 hasRelatedWork W2017956702 @default.
• W3116641519 hasRelatedWork W2031324182 @default.
• W3116641519 hasRelatedWork W2046618695 @default.
• W3116641519 hasRelatedWork W2067898373 @default.
• W3116641519 hasRelatedWork W2172226517 @default.
• W3116641519 hasRelatedWork W2511963020 @default.

• next