FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116705951> ?p ?o ?g. }

• W3116705951 abstract "Introduction. Historically, pesticides are evaluated more strictly from a medical point of view than other chemicals. Since their features, such as deliberate introduction into the environment, the possibility of contact with them by large masses of the population, and the high biological activity determine their potential danger to humans. Purpose of research - study of the biological effect of a technical product derived from triazoles when it is repeatedly ingested orally in mammals (rats), establishment of inactive and active doses, justification of the permissible daily dose (DSD) for humans. Material and methods. In acute experiments, white rats were used, including 6 animals in the group. Tested dose: 500-4000 mg/kg of body weight. A chronic (12 months) experiment was performed on 80 male rats with a bodyweight of 180-190 g at the beginning of the study. Tested doses: 5.0; 16.0 and 55.0 mg/kg of body weight (1 control and 3 experimental animals, 20 individuals each). In the dynamics of the experiment, we observed the condition and behavior of animals, water, and food consumption, recorded the timing of death, changes in body weight, physiological, biochemical, and hematological indices. Results. Indices of the acute oral toxicity on the studied product LD50 male rats were 2250 ± 483 mg/kg body weight. The dose of 5.0 mg / kg of body weight was not found to cause significant changes in all studied indices. The doses of 16.0 and 55.0 mg/kg of body weight had a polytropic effect on the body in experimental animals. Discussion. The studied product for the acute oral toxicity refers to low-hazard compounds, the doses of 16.0 and 55.0 mg/kg of body weight has a polytropic effect on the mammalian body, causing changes in carbohydrate, lipid, and lipoprotein metabolism in the body of rats - was accepted as acting. The dose of 5.0 mg / kg of body weight, when administered in rats, there are no changes in all the studied parameters throughout the experiment, is accepted as invalid. Based on the inactive dose-5.0 mg/kg of body weight and taking into account the reserve factor of 100, we have scientifically justified DSD for a person at the level of 0.05 mg/kg. Summary. The conducted sanitary and Toxicological studies indicate the need to assess the toxicity of new technical products to the mammalian body, to increase the reliability of the developed hygiene standards in environmental objects and food products." @default.
• W3116705951 created "2021-01-05" @default.
• W3116705951 creator A5026965804 @default.
• W3116705951 creator A5052022393 @default.
• W3116705951 creator A5074911617 @default.
• W3116705951 date "2020-12-22" @default.
• W3116705951 modified "2023-09-26" @default.
• W3116705951 title "Toxicity assessment of a technical product of the triazole class" @default.
• W3116705951 cites W2514197208 @default.
• W3116705951 cites W2990881219 @default.
• W3116705951 cites W3034025355 @default.
• W3116705951 doi "https://doi.org/10.47470/0016-9900-2020-99-11-1276-1279" @default.
• W3116705951 hasPublicationYear "2020" @default.
• W3116705951 type Work @default.
• W3116705951 sameAs 3116705951 @default.
• W3116705951 citedByCount "0" @default.
• W3116705951 crossrefType "journal-article" @default.
• W3116705951 hasAuthorship W3116705951A5026965804 @default.
• W3116705951 hasAuthorship W3116705951A5052022393 @default.
• W3116705951 hasAuthorship W3116705951A5074911617 @default.
• W3116705951 hasBestOaLocation W31167059511 @default.
• W3116705951 hasConcept C116263406 @default.
• W3116705951 hasConcept C126322002 @default.
• W3116705951 hasConcept C140793950 @default.
• W3116705951 hasConcept C147583825 @default.
• W3116705951 hasConcept C167552308 @default.
• W3116705951 hasConcept C2908647359 @default.
• W3116705951 hasConcept C29730261 @default.
• W3116705951 hasConcept C33070731 @default.
• W3116705951 hasConcept C42407357 @default.
• W3116705951 hasConcept C71924100 @default.
• W3116705951 hasConcept C86803240 @default.
• W3116705951 hasConcept C99454951 @default.
• W3116705951 hasConceptScore W3116705951C116263406 @default.
• W3116705951 hasConceptScore W3116705951C126322002 @default.
• W3116705951 hasConceptScore W3116705951C140793950 @default.
• W3116705951 hasConceptScore W3116705951C147583825 @default.
• W3116705951 hasConceptScore W3116705951C167552308 @default.
• W3116705951 hasConceptScore W3116705951C2908647359 @default.
• W3116705951 hasConceptScore W3116705951C29730261 @default.
• W3116705951 hasConceptScore W3116705951C33070731 @default.
• W3116705951 hasConceptScore W3116705951C42407357 @default.
• W3116705951 hasConceptScore W3116705951C71924100 @default.
• W3116705951 hasConceptScore W3116705951C86803240 @default.
• W3116705951 hasConceptScore W3116705951C99454951 @default.
• W3116705951 hasLocation W31167059511 @default.
• W3116705951 hasOpenAccess W3116705951 @default.
• W3116705951 hasPrimaryLocation W31167059511 @default.
• W3116705951 hasRelatedWork W100021 @default.
• W3116705951 hasRelatedWork W12171308 @default.
• W3116705951 hasRelatedWork W1641019 @default.
• W3116705951 hasRelatedWork W17963140 @default.
• W3116705951 hasRelatedWork W1799442 @default.
• W3116705951 hasRelatedWork W18510784 @default.
• W3116705951 hasRelatedWork W2820280 @default.
• W3116705951 hasRelatedWork W8122116 @default.
• W3116705951 hasRelatedWork W8951790 @default.
• W3116705951 hasRelatedWork W9051065 @default.
• W3116705951 isParatext "false" @default.
• W3116705951 isRetracted "false" @default.
• W3116705951 magId "3116705951" @default.
• W3116705951 workType "article" @default.