FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116753357> ?p ?o ?g. }

• W3116753357 endingPage "104584" @default.
• W3116753357 startingPage "104584" @default.
• W3116753357 abstract "Natural pterocarpans and synthetic 5-carba-pterocarpans are isosteres in which the oxygen atom at position 5 in the pyran-ring of pterocarpans is replaced by a methylene group. These 5-carba-analogues were obtained in good yields through the palladium-catalyzed oxyarylation of alcoxy-1,2-dihydronaphthalens with o -iodophenols in PEG-400. They were evaluated on human cancer cell lineages derived respectively from prostate tumor (PC3, IC 50 = 11.84 μmol L −1 , SI > 12)) and acute myeloid leukemia (HL-60, IC 50 = 8.81 μmol L −1 , SI > 16), highly incident cancer types presenting resistance against traditional chemotherapeutics. Compound 6c (LQB-492) was the most potent (IC 50 = 3.85 μmol L −1 , SI > 37) in SF-295 cell lineage (glioblastoma). Such findings suggest that 5-carba-pterocarpan can potentially be new hit compounds for further development of novel antiproliferative agents." @default.
• W3116753357 created "2021-01-05" @default.
• W3116753357 creator A5020860820 @default.
• W3116753357 creator A5022661530 @default.
• W3116753357 creator A5026529358 @default.
• W3116753357 creator A5050665255 @default.
• W3116753357 creator A5051377893 @default.
• W3116753357 creator A5071855435 @default.
• W3116753357 creator A5077804323 @default.
• W3116753357 creator A5085996432 @default.
• W3116753357 creator A5089022269 @default.
• W3116753357 date "2021-02-01" @default.
• W3116753357 modified "2023-09-27" @default.
• W3116753357 title "New 5-carba-pterocarpans: Synthesis and preliminary antiproliferative activity on a panel of human cancer cells" @default.
• W3116753357 cites W1971168272 @default.
• W3116753357 cites W1982288977 @default.
• W3116753357 cites W1988683007 @default.
• W3116753357 cites W2001274141 @default.
• W3116753357 cites W2021934015 @default.
• W3116753357 cites W2023922278 @default.
• W3116753357 cites W2037323330 @default.
• W3116753357 cites W2039203038 @default.
• W3116753357 cites W2045976529 @default.
• W3116753357 cites W2050616452 @default.
• W3116753357 cites W2055904567 @default.
• W3116753357 cites W2064031621 @default.
• W3116753357 cites W2074686601 @default.
• W3116753357 cites W2114918609 @default.
• W3116753357 cites W2115228747 @default.
• W3116753357 cites W2116942253 @default.
• W3116753357 cites W2137992226 @default.
• W3116753357 cites W2170552969 @default.
• W3116753357 cites W2311478485 @default.
• W3116753357 cites W2501769632 @default.
• W3116753357 cites W2542092550 @default.
• W3116753357 cites W2552560251 @default.
• W3116753357 cites W2762850531 @default.
• W3116753357 cites W2949202802 @default.
• W3116753357 cites W3026787564 @default.
• W3116753357 cites W3091012051 @default.
• W3116753357 doi "https://doi.org/10.1016/j.bioorg.2020.104584" @default.
• W3116753357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33453646" @default.
• W3116753357 hasPublicationYear "2021" @default.
• W3116753357 type Work @default.
• W3116753357 sameAs 3116753357 @default.
• W3116753357 citedByCount "3" @default.
• W3116753357 countsByYear W31167533572021 @default.
• W3116753357 countsByYear W31167533572022 @default.
• W3116753357 crossrefType "journal-article" @default.
• W3116753357 hasAuthorship W3116753357A5020860820 @default.
• W3116753357 hasAuthorship W3116753357A5022661530 @default.
• W3116753357 hasAuthorship W3116753357A5026529358 @default.
• W3116753357 hasAuthorship W3116753357A5050665255 @default.
• W3116753357 hasAuthorship W3116753357A5051377893 @default.
• W3116753357 hasAuthorship W3116753357A5071855435 @default.
• W3116753357 hasAuthorship W3116753357A5077804323 @default.
• W3116753357 hasAuthorship W3116753357A5085996432 @default.
• W3116753357 hasAuthorship W3116753357A5089022269 @default.
• W3116753357 hasConcept C121608353 @default.
• W3116753357 hasConcept C155647269 @default.
• W3116753357 hasConcept C178790620 @default.
• W3116753357 hasConcept C185592680 @default.
• W3116753357 hasConcept C2777454769 @default.
• W3116753357 hasConcept C2778729363 @default.
• W3116753357 hasConcept C2780378348 @default.
• W3116753357 hasConcept C502942594 @default.
• W3116753357 hasConcept C54355233 @default.
• W3116753357 hasConcept C71240020 @default.
• W3116753357 hasConcept C86803240 @default.
• W3116753357 hasConcept C96232424 @default.
• W3116753357 hasConceptScore W3116753357C121608353 @default.
• W3116753357 hasConceptScore W3116753357C155647269 @default.
• W3116753357 hasConceptScore W3116753357C178790620 @default.
• W3116753357 hasConceptScore W3116753357C185592680 @default.
• W3116753357 hasConceptScore W3116753357C2777454769 @default.
• W3116753357 hasConceptScore W3116753357C2778729363 @default.
• W3116753357 hasConceptScore W3116753357C2780378348 @default.
• W3116753357 hasConceptScore W3116753357C502942594 @default.
• W3116753357 hasConceptScore W3116753357C54355233 @default.
• W3116753357 hasConceptScore W3116753357C71240020 @default.
• W3116753357 hasConceptScore W3116753357C86803240 @default.
• W3116753357 hasConceptScore W3116753357C96232424 @default.
• W3116753357 hasLocation W31167533571 @default.
• W3116753357 hasOpenAccess W3116753357 @default.
• W3116753357 hasPrimaryLocation W31167533571 @default.
• W3116753357 hasRelatedWork W1963603731 @default.
• W3116753357 hasRelatedWork W1990592087 @default.
• W3116753357 hasRelatedWork W2131218738 @default.
• W3116753357 hasRelatedWork W2347013525 @default.
• W3116753357 hasRelatedWork W2396526554 @default.
• W3116753357 hasRelatedWork W2604203886 @default.
• W3116753357 hasRelatedWork W2950038481 @default.
• W3116753357 hasRelatedWork W2950436718 @default.
• W3116753357 hasRelatedWork W2950952629 @default.
• W3116753357 hasRelatedWork W3015795223 @default.
• W3116753357 hasVolume "107" @default.
• W3116753357 isParatext "false" @default.
• W3116753357 isRetracted "false" @default.

• next