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- W3116756937 abstract "The EkoSonic endovascular system has been cleared by the U.S. Food and Drug Administration for the controlled and selective infusion of physician specified fluids, including thrombolytics, into the peripheral vasculature and the pulmonary arteries. The objective of this study was to explore whether this catheter technology could sustain cavitation nucleated by infused Definity, to support subsequent studies of ultrasound-mediated drug delivery to diseased arteries. The concentration and attenuation spectroscopy of Definity were assayed before and after infusion at 0.3, 2.0 and 4.0 mL/min through the EkoSonic catheter. PCI was used to map and quantify stable and inertial cavitation as a function of Definity concentration in a flow phantom mimicking the porcine femoral artery. The 2.0 mL/min infusion rate yielded the highest surviving Definity concentration and acoustic attenuation. Cavitation was sustained throughout each 15 ms ultrasound pulse, as well as throughout the 3 min infusion. These results demonstrate a potential pathway to use cavitation nucleation to promote drug delivery with the EkoSonic endovascular system." @default.
- W3116756937 created "2021-01-05" @default.
- W3116756937 creator A5009840006 @default.
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- W3116756937 creator A5056239813 @default.
- W3116756937 creator A5066758099 @default.
- W3116756937 creator A5067906379 @default.
- W3116756937 creator A5080574600 @default.
- W3116756937 date "2021-03-01" @default.
- W3116756937 modified "2023-10-17" @default.
- W3116756937 title "Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom" @default.
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