FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116782148> ?p ?o ?g. }

• W3116782148 endingPage "9" @default.
• W3116782148 startingPage "9" @default.
• W3116782148 abstract "Targeting the tumor vasculature is an attractive strategy for cancer treatment. However, the tumor vasculature is heterogeneous, and the mechanisms involved in the neovascularization of tumors are highly complex. Vasculogenic mimicry (VM) refers to the formation of vessel-like structures by tumor cells, which can contribute to tumor neovascularization, and is closely related to metastasis and a poor prognosis. Here, we report a novel function of AXL receptor tyrosine kinase (AXL) in the regulation of VM formation in breast cancer cells. MDA-MB-231 cells exhibited VM formation on Matrigel cultures, whereas MCF-7 cells did not. Moreover, AXL expression was positively correlated with VM formation. Pharmacological inhibition or AXL knockdown strongly suppressed VM formation in MDA-MB-231 cells, whereas the overexpression of AXL in MCF-7 cells promoted VM formation. In addition, AXL knockdown regulated epithelial–mesenchymal transition (EMT) features, increasing cell invasion and migration in MDA-MB-231 cells. Finally, the overexpression of microRNA-34a (miR-34a), which is a well-described EMT-inhibiting miRNA and targets AXL, inhibited VM formation, migration, and invasion in MDA-MB 231 cells. These results identify a miR-34a–AXL axis that is critical for the regulation of VM formation and may serve as a therapeutic target to inhibit tumor neovascularization." @default.
• W3116782148 created "2021-01-05" @default.
• W3116782148 creator A5003130642 @default.
• W3116782148 creator A5024756988 @default.
• W3116782148 creator A5032052510 @default.
• W3116782148 creator A5035232096 @default.
• W3116782148 creator A5045502888 @default.
• W3116782148 creator A5048277865 @default.
• W3116782148 creator A5060125937 @default.
• W3116782148 creator A5064440520 @default.
• W3116782148 creator A5073581912 @default.
• W3116782148 creator A5086982270 @default.
• W3116782148 creator A5089144306 @default.
• W3116782148 date "2020-12-23" @default.
• W3116782148 modified "2023-10-03" @default.
• W3116782148 title "MicroRNA 34a–AXL Axis Regulates Vasculogenic Mimicry Formation in Breast Cancer Cells" @default.
• W3116782148 cites W1256125786 @default.
• W3116782148 cites W155717428 @default.
• W3116782148 cites W1935073111 @default.
• W3116782148 cites W1969192247 @default.
• W3116782148 cites W1970856908 @default.
• W3116782148 cites W1995224853 @default.
• W3116782148 cites W2002995168 @default.
• W3116782148 cites W2003445065 @default.
• W3116782148 cites W2018056175 @default.
• W3116782148 cites W2022700890 @default.
• W3116782148 cites W2032927240 @default.
• W3116782148 cites W2032943116 @default.
• W3116782148 cites W2037528691 @default.
• W3116782148 cites W2045604306 @default.
• W3116782148 cites W2051599263 @default.
• W3116782148 cites W2057981272 @default.
• W3116782148 cites W2063725583 @default.
• W3116782148 cites W2067907901 @default.
• W3116782148 cites W2067958384 @default.
• W3116782148 cites W2086977969 @default.
• W3116782148 cites W2104754475 @default.
• W3116782148 cites W2126294543 @default.
• W3116782148 cites W2145896896 @default.
• W3116782148 cites W2147054592 @default.
• W3116782148 cites W2170602872 @default.
• W3116782148 cites W2203427671 @default.
• W3116782148 cites W2319938999 @default.
• W3116782148 cites W2414098557 @default.
• W3116782148 cites W2417831449 @default.
• W3116782148 cites W2520923408 @default.
• W3116782148 cites W2523391168 @default.
• W3116782148 cites W2549442450 @default.
• W3116782148 cites W2561086413 @default.
• W3116782148 cites W2594906601 @default.
• W3116782148 cites W2603942390 @default.
• W3116782148 cites W2621299847 @default.
• W3116782148 cites W2727463864 @default.
• W3116782148 cites W2762285338 @default.
• W3116782148 cites W2765386661 @default.
• W3116782148 cites W2765862227 @default.
• W3116782148 cites W2768772819 @default.
• W3116782148 cites W2783417402 @default.
• W3116782148 cites W2917796704 @default.
• W3116782148 cites W2918356672 @default.
• W3116782148 cites W2926041212 @default.
• W3116782148 cites W2982495645 @default.
• W3116782148 cites W2987630755 @default.
• W3116782148 cites W3028472215 @default.
• W3116782148 doi "https://doi.org/10.3390/genes12010009" @default.
• W3116782148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7823537" @default.
• W3116782148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33374832" @default.
• W3116782148 hasPublicationYear "2020" @default.
• W3116782148 type Work @default.
• W3116782148 sameAs 3116782148 @default.
• W3116782148 citedByCount "12" @default.
• W3116782148 countsByYear W31167821482021 @default.
• W3116782148 countsByYear W31167821482022 @default.
• W3116782148 countsByYear W31167821482023 @default.
• W3116782148 crossrefType "journal-article" @default.
• W3116782148 hasAuthorship W3116782148A5003130642 @default.
• W3116782148 hasAuthorship W3116782148A5024756988 @default.
• W3116782148 hasAuthorship W3116782148A5032052510 @default.
• W3116782148 hasAuthorship W3116782148A5035232096 @default.
• W3116782148 hasAuthorship W3116782148A5045502888 @default.
• W3116782148 hasAuthorship W3116782148A5048277865 @default.
• W3116782148 hasAuthorship W3116782148A5060125937 @default.
• W3116782148 hasAuthorship W3116782148A5064440520 @default.
• W3116782148 hasAuthorship W3116782148A5073581912 @default.
• W3116782148 hasAuthorship W3116782148A5086982270 @default.
• W3116782148 hasAuthorship W3116782148A5089144306 @default.
• W3116782148 hasBestOaLocation W31167821481 @default.
• W3116782148 hasConcept C101544691 @default.
• W3116782148 hasConcept C104317684 @default.
• W3116782148 hasConcept C121608353 @default.
• W3116782148 hasConcept C137738243 @default.
• W3116782148 hasConcept C145059251 @default.
• W3116782148 hasConcept C1491633281 @default.
• W3116782148 hasConcept C157333092 @default.
• W3116782148 hasConcept C172811965 @default.
• W3116782148 hasConcept C173396325 @default.
• W3116782148 hasConcept C185592680 @default.
• W3116782148 hasConcept C2778271429 @default.

• next