FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116844483> ?p ?o ?g. }

• W3116844483 abstract "ABSTRACT The arms race between bacteria and phages has led to the development of exquisite bacterial defense systems including a number of uncharacterized systems distinct from the well-known Restriction-Modification and CRISPR/Cas systems. Here, we report functional analyses of the GajA protein from the newly predicted Gabija system. The GajA protein is revealed as an endonuclease unique in that: 1. It may function as a restriction enzyme or a site-specific nicking enzyme, depending on the arrangement of the recognition sequences; 2. Its activity is strictly regulated by nucleotides concentration. NTP and dNTP at physiological concentrations can fully inhibited the robust DNA cleavage activity of GajA. Interestingly, the nucleotide inhibition is mediated by an ATPase-like domain, which usually hydrolyzes ATP to stimulate the DNA cleavage when associated with other nucleases. These features suggested the mechanism of the Gabija defense in which an endonuclease activity was suppressed at normal condition, while activated by the depletion of NTP and dNTP upon the replication and transcription by invaded phages. This work highlights a concise strategy to utilize a single protein for phage resistance via nucleotide regulatory." @default.
• W3116844483 created "2021-01-05" @default.
• W3116844483 creator A5001906955 @default.
• W3116844483 creator A5014117578 @default.
• W3116844483 creator A5023213159 @default.
• W3116844483 creator A5026628071 @default.
• W3116844483 creator A5048411184 @default.
• W3116844483 creator A5051310672 @default.
• W3116844483 creator A5055553438 @default.
• W3116844483 creator A5081821056 @default.
• W3116844483 date "2020-12-20" @default.
• W3116844483 modified "2023-10-05" @default.
• W3116844483 title "A nucleotide-sensing endonuclease from the Gabija bacterial defense system" @default.
• W3116844483 cites W1630678156 @default.
• W3116844483 cites W1971439989 @default.
• W3116844483 cites W1972708645 @default.
• W3116844483 cites W1986529984 @default.
• W3116844483 cites W1987707286 @default.
• W3116844483 cites W1995867192 @default.
• W3116844483 cites W2019197162 @default.
• W3116844483 cites W2022429794 @default.
• W3116844483 cites W2033435879 @default.
• W3116844483 cites W2068056297 @default.
• W3116844483 cites W2080668718 @default.
• W3116844483 cites W2086103567 @default.
• W3116844483 cites W2087680916 @default.
• W3116844483 cites W2095624846 @default.
• W3116844483 cites W2108101601 @default.
• W3116844483 cites W2108804414 @default.
• W3116844483 cites W2110045185 @default.
• W3116844483 cites W2118473805 @default.
• W3116844483 cites W2121453804 @default.
• W3116844483 cites W2137168241 @default.
• W3116844483 cites W2140848003 @default.
• W3116844483 cites W2149142276 @default.
• W3116844483 cites W2169244146 @default.
• W3116844483 cites W2184457948 @default.
• W3116844483 cites W2784532673 @default.
• W3116844483 cites W2965856049 @default.
• W3116844483 cites W3003219583 @default.
• W3116844483 cites W3033444158 @default.
• W3116844483 cites W3063215485 @default.
• W3116844483 cites W3081228941 @default.
• W3116844483 doi "https://doi.org/10.1101/2020.12.18.423425" @default.
• W3116844483 hasPublicationYear "2020" @default.
• W3116844483 type Work @default.
• W3116844483 sameAs 3116844483 @default.
• W3116844483 citedByCount "0" @default.
• W3116844483 crossrefType "posted-content" @default.
• W3116844483 hasAuthorship W3116844483A5001906955 @default.
• W3116844483 hasAuthorship W3116844483A5014117578 @default.
• W3116844483 hasAuthorship W3116844483A5023213159 @default.
• W3116844483 hasAuthorship W3116844483A5026628071 @default.
• W3116844483 hasAuthorship W3116844483A5048411184 @default.
• W3116844483 hasAuthorship W3116844483A5051310672 @default.
• W3116844483 hasAuthorship W3116844483A5055553438 @default.
• W3116844483 hasAuthorship W3116844483A5081821056 @default.
• W3116844483 hasBestOaLocation W31168444831 @default.
• W3116844483 hasConcept C104317684 @default.
• W3116844483 hasConcept C128319531 @default.
• W3116844483 hasConcept C151730666 @default.
• W3116844483 hasConcept C153911025 @default.
• W3116844483 hasConcept C175156509 @default.
• W3116844483 hasConcept C181199279 @default.
• W3116844483 hasConcept C2777028655 @default.
• W3116844483 hasConcept C43369102 @default.
• W3116844483 hasConcept C512185932 @default.
• W3116844483 hasConcept C552990157 @default.
• W3116844483 hasConcept C55493867 @default.
• W3116844483 hasConcept C86803240 @default.
• W3116844483 hasConcept C95444343 @default.
• W3116844483 hasConcept C98108389 @default.
• W3116844483 hasConceptScore W3116844483C104317684 @default.
• W3116844483 hasConceptScore W3116844483C128319531 @default.
• W3116844483 hasConceptScore W3116844483C151730666 @default.
• W3116844483 hasConceptScore W3116844483C153911025 @default.
• W3116844483 hasConceptScore W3116844483C175156509 @default.
• W3116844483 hasConceptScore W3116844483C181199279 @default.
• W3116844483 hasConceptScore W3116844483C2777028655 @default.
• W3116844483 hasConceptScore W3116844483C43369102 @default.
• W3116844483 hasConceptScore W3116844483C512185932 @default.
• W3116844483 hasConceptScore W3116844483C552990157 @default.
• W3116844483 hasConceptScore W3116844483C55493867 @default.
• W3116844483 hasConceptScore W3116844483C86803240 @default.
• W3116844483 hasConceptScore W3116844483C95444343 @default.
• W3116844483 hasConceptScore W3116844483C98108389 @default.
• W3116844483 hasLocation W31168444831 @default.
• W3116844483 hasOpenAccess W3116844483 @default.
• W3116844483 hasPrimaryLocation W31168444831 @default.
• W3116844483 hasRelatedWork W1477238300 @default.
• W3116844483 hasRelatedWork W2033228035 @default.
• W3116844483 hasRelatedWork W2038816407 @default.
• W3116844483 hasRelatedWork W2070459986 @default.
• W3116844483 hasRelatedWork W2088519907 @default.
• W3116844483 hasRelatedWork W2376515225 @default.
• W3116844483 hasRelatedWork W2418350746 @default.
• W3116844483 hasRelatedWork W2419677653 @default.
• W3116844483 hasRelatedWork W2470191688 @default.
• W3116844483 hasRelatedWork W4306160392 @default.
• W3116844483 isParatext "false" @default.

• next