Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116948397> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W3116948397 endingPage "1610" @default.
- W3116948397 startingPage "1605" @default.
- W3116948397 abstract "Purpose: To investigate the involvement of ruscogenin in palmitic acid (PA)-induced endothelial cell inflammation.
 Method: Cultured human umbilical vein endothelial cells (HUVECs) were divided into five groups: control (normal untreated cells), PA (cell treated with palmitic acid), and PA + ruscogenin (1, 10, or 30 μM). Cell viability and apoptosis rate were determined using MTT (3-(4,5)-dimethylthiahiazo(-z-y1)-3,5- di-phenytetrazolium bromide) and flow cytometry assays, respectively. The levels of cytokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemo-attractant protein-1 (MCP-1) were determined by an enzyme-linked immunosorbent assay. Western blotting and real-time polymerase chain reaction (RT-PCR) were used to evaluate the underlying mechanisms of action.
 Results: PA treatment decreased the viability of HUVECs and induced apoptosis (p < 0.05). Ruscogenin attenuated PA-induced cell death in a dose-dependent manner (p < 0.05). On the other hand, PA induced an increase in IL-1β, TNF-α, ICAM-1, MCP-1, TXNIP (thioredoxin-interacting protein),as well as NLRP3 (nucleotide oligomerization domain-, leucine-rich repeat- and pyrin domain-containing protein 3), all of which were attenuated by ruscogenin (p < 0.05).
 Conclusion: Ruscogenin alleviates PA-induced endothelial cell inflammation via TXNIP/NLRP3 pathway, thereby providing an insight into new therapeutic strategies to treat cardiovascular diseases.
 Keywords: Ruscogenin, Palmitic acid, Endothelial cells, Inflammation, TXNIP, NLRP3, Cardiovascular diseases" @default.
- W3116948397 created "2021-01-05" @default.
- W3116948397 creator A5026392276 @default.
- W3116948397 creator A5064251720 @default.
- W3116948397 creator A5071680326 @default.
- W3116948397 creator A5079417201 @default.
- W3116948397 date "2020-11-18" @default.
- W3116948397 modified "2023-10-17" @default.
- W3116948397 title "Ruscogenin alleviates palmitic acid-induced endothelial cell inflammation by suppressing TXNIP/NLRP3 pathway" @default.
- W3116948397 doi "https://doi.org/10.4314/tjpr.v19i8.6" @default.
- W3116948397 hasPublicationYear "2020" @default.
- W3116948397 type Work @default.
- W3116948397 sameAs 3116948397 @default.
- W3116948397 citedByCount "0" @default.
- W3116948397 crossrefType "journal-article" @default.
- W3116948397 hasAuthorship W3116948397A5026392276 @default.
- W3116948397 hasAuthorship W3116948397A5064251720 @default.
- W3116948397 hasAuthorship W3116948397A5071680326 @default.
- W3116948397 hasAuthorship W3116948397A5079417201 @default.
- W3116948397 hasBestOaLocation W31169483971 @default.
- W3116948397 hasConcept C153911025 @default.
- W3116948397 hasConcept C17991360 @default.
- W3116948397 hasConcept C185592680 @default.
- W3116948397 hasConcept C190283241 @default.
- W3116948397 hasConcept C203014093 @default.
- W3116948397 hasConcept C2776151105 @default.
- W3116948397 hasConcept C2776914184 @default.
- W3116948397 hasConcept C2779076967 @default.
- W3116948397 hasConcept C2779936771 @default.
- W3116948397 hasConcept C3623737 @default.
- W3116948397 hasConcept C53227056 @default.
- W3116948397 hasConcept C543025807 @default.
- W3116948397 hasConcept C55493867 @default.
- W3116948397 hasConcept C86803240 @default.
- W3116948397 hasConcept C98274493 @default.
- W3116948397 hasConceptScore W3116948397C153911025 @default.
- W3116948397 hasConceptScore W3116948397C17991360 @default.
- W3116948397 hasConceptScore W3116948397C185592680 @default.
- W3116948397 hasConceptScore W3116948397C190283241 @default.
- W3116948397 hasConceptScore W3116948397C203014093 @default.
- W3116948397 hasConceptScore W3116948397C2776151105 @default.
- W3116948397 hasConceptScore W3116948397C2776914184 @default.
- W3116948397 hasConceptScore W3116948397C2779076967 @default.
- W3116948397 hasConceptScore W3116948397C2779936771 @default.
- W3116948397 hasConceptScore W3116948397C3623737 @default.
- W3116948397 hasConceptScore W3116948397C53227056 @default.
- W3116948397 hasConceptScore W3116948397C543025807 @default.
- W3116948397 hasConceptScore W3116948397C55493867 @default.
- W3116948397 hasConceptScore W3116948397C86803240 @default.
- W3116948397 hasConceptScore W3116948397C98274493 @default.
- W3116948397 hasIssue "8" @default.
- W3116948397 hasLocation W31169483971 @default.
- W3116948397 hasOpenAccess W3116948397 @default.
- W3116948397 hasPrimaryLocation W31169483971 @default.
- W3116948397 hasRelatedWork W2091200466 @default.
- W3116948397 hasRelatedWork W2182837698 @default.
- W3116948397 hasRelatedWork W2329860900 @default.
- W3116948397 hasRelatedWork W2362514185 @default.
- W3116948397 hasRelatedWork W2366761680 @default.
- W3116948397 hasRelatedWork W2371124523 @default.
- W3116948397 hasRelatedWork W2380010871 @default.
- W3116948397 hasRelatedWork W2383837582 @default.
- W3116948397 hasRelatedWork W2472820331 @default.
- W3116948397 hasRelatedWork W376324198 @default.
- W3116948397 hasVolume "19" @default.
- W3116948397 isParatext "false" @default.
- W3116948397 isRetracted "false" @default.
- W3116948397 magId "3116948397" @default.
- W3116948397 workType "article" @default.