FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3116994906> ?p ?o ?g. }

• W3116994906 endingPage "1259" @default.
• W3116994906 startingPage "1245" @default.
• W3116994906 abstract "The change in the levels of peripheral inflammatory markers together with EGFR in relation to 5- fluorouracil (5-FU) therapy was evaluated for their prognostic significance in colorectal cancer (CRC) patients.Expression levels of COX2, IL6, IL1β, EGFR, IL10, and TNFα were determined with quantitative real-time PCR (qPCR) in the peripheral blood of 90 CRC patients. The inflammatory response was correlated with patients' clinical features, disease-free survival (DFS), and overall survival (OS).After 6 months of 5-FU therapy, increased inflammatory response was found to be associated with smoking, T3 or T4 tumors, performance status (PS) III, positive lymph nodes, distant metastasis, and gastrointestinal (GIT) toxicity. The combination of COX2 with interleukins in a predictive equation for DFS was significant in patients with over-expression of EGFR. DFS and OS rates were reduced in patients with increased COX2, IL6, IL10, and TNFα expression with 5-FU therapy. Significant hazard of disease progression was associated with smoking (HR=1.27, P=0.004), 5-FU induction of COX2, and IL6 expression (HR=1.35, P=0.001 and HR=1.27, P=0.004, respectively). Moreover, smoking, 5-FU induction of IL6, TNFα, and IL10 expression are found to be independent prognostic factors for OS (P=0.003, 0.003, 0.002, and 0.002, respectively).The peripheral effects of 5-FU therapy have shown a significant impact on the treatment outcome of CRC patients." @default.
• W3116994906 created "2021-01-05" @default.
• W3116994906 creator A5021084336 @default.
• W3116994906 creator A5033406657 @default.
• W3116994906 creator A5034000985 @default.
• W3116994906 creator A5038538552 @default.
• W3116994906 creator A5079570684 @default.
• W3116994906 creator A5079823534 @default.
• W3116994906 creator A5084237815 @default.
• W3116994906 date "2020-12-01" @default.
• W3116994906 modified "2023-10-18" @default.
• W3116994906 title "The Prognostic Significance of 5-Fluorouracil Induced Inflammation and Immuno-Modulation in Colorectal Cancer Patients" @default.
• W3116994906 cites W1232771652 @default.
• W3116994906 cites W1586425132 @default.
• W3116994906 cites W1959558273 @default.
• W3116994906 cites W1977064103 @default.
• W3116994906 cites W1978054127 @default.
• W3116994906 cites W1980669422 @default.
• W3116994906 cites W1981326224 @default.
• W3116994906 cites W1984409435 @default.
• W3116994906 cites W1985540222 @default.
• W3116994906 cites W1987253875 @default.
• W3116994906 cites W1995607891 @default.
• W3116994906 cites W1996349289 @default.
• W3116994906 cites W2006330201 @default.
• W3116994906 cites W2018315438 @default.
• W3116994906 cites W2021324583 @default.
• W3116994906 cites W2030177138 @default.
• W3116994906 cites W2045568806 @default.
• W3116994906 cites W2075524348 @default.
• W3116994906 cites W2098530922 @default.
• W3116994906 cites W2103846273 @default.
• W3116994906 cites W2114170995 @default.
• W3116994906 cites W2152187133 @default.
• W3116994906 cites W2159848047 @default.
• W3116994906 cites W2169816885 @default.
• W3116994906 cites W2171467964 @default.
• W3116994906 cites W2207750272 @default.
• W3116994906 cites W2258320918 @default.
• W3116994906 cites W2283733133 @default.
• W3116994906 cites W2329937381 @default.
• W3116994906 cites W2340194153 @default.
• W3116994906 cites W2397006483 @default.
• W3116994906 cites W2600115309 @default.
• W3116994906 cites W2620648392 @default.
• W3116994906 cites W2748786482 @default.
• W3116994906 cites W2755476534 @default.
• W3116994906 cites W2757812515 @default.
• W3116994906 cites W2807273450 @default.
• W3116994906 cites W2885262526 @default.
• W3116994906 cites W2887348851 @default.
• W3116994906 cites W2898079638 @default.
• W3116994906 cites W2921362447 @default.
• W3116994906 cites W2935748755 @default.
• W3116994906 cites W2967224347 @default.
• W3116994906 cites W2970045605 @default.
• W3116994906 cites W2990052644 @default.
• W3116994906 cites W4230934581 @default.
• W3116994906 doi "https://doi.org/10.2147/jir.s283069" @default.
• W3116994906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7781028" @default.
• W3116994906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33408498" @default.
• W3116994906 hasPublicationYear "2020" @default.
• W3116994906 type Work @default.
• W3116994906 sameAs 3116994906 @default.
• W3116994906 citedByCount "7" @default.
• W3116994906 countsByYear W31169949062021 @default.
• W3116994906 countsByYear W31169949062022 @default.
• W3116994906 countsByYear W31169949062023 @default.
• W3116994906 crossrefType "journal-article" @default.
• W3116994906 hasAuthorship W3116994906A5021084336 @default.
• W3116994906 hasAuthorship W3116994906A5033406657 @default.
• W3116994906 hasAuthorship W3116994906A5034000985 @default.
• W3116994906 hasAuthorship W3116994906A5038538552 @default.
• W3116994906 hasAuthorship W3116994906A5079570684 @default.
• W3116994906 hasAuthorship W3116994906A5079823534 @default.
• W3116994906 hasAuthorship W3116994906A5084237815 @default.
• W3116994906 hasBestOaLocation W31169949061 @default.
• W3116994906 hasConcept C121608353 @default.
• W3116994906 hasConcept C126322002 @default.
• W3116994906 hasConcept C143998085 @default.
• W3116994906 hasConcept C187316574 @default.
• W3116994906 hasConcept C2778690821 @default.
• W3116994906 hasConcept C2780456651 @default.
• W3116994906 hasConcept C526805850 @default.
• W3116994906 hasConcept C63363279 @default.
• W3116994906 hasConcept C71924100 @default.
• W3116994906 hasConcept C90924648 @default.
• W3116994906 hasConceptScore W3116994906C121608353 @default.
• W3116994906 hasConceptScore W3116994906C126322002 @default.
• W3116994906 hasConceptScore W3116994906C143998085 @default.
• W3116994906 hasConceptScore W3116994906C187316574 @default.
• W3116994906 hasConceptScore W3116994906C2778690821 @default.
• W3116994906 hasConceptScore W3116994906C2780456651 @default.
• W3116994906 hasConceptScore W3116994906C526805850 @default.
• W3116994906 hasConceptScore W3116994906C63363279 @default.
• W3116994906 hasConceptScore W3116994906C71924100 @default.
• W3116994906 hasConceptScore W3116994906C90924648 @default.
• W3116994906 hasLocation W31169949061 @default.

• next