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• W3116996811 abstract "Introduction Evidence suggests that Crohn's disease (CD) pathophysiology goes beyond the gastrointestinal tract and is also strongly associated with the brain. In particular, the anterior cingulate cortex (ACC), which plays an integral role in the first brain as part of the default mode network (DMN) and pain matrix, shows abnormalities using multiple neuroimaging modalities. This review summarizes nine related studies that investigated changes in the ACC using structural magnetic resonance imaging, resting-state functional magnetic resonance imaging, and magnetic resonance spectroscopy. Methods An extensive PubMed literature search was conducted from 1980 to August 2020. In a review of the articles identified, particular attention was paid to analysis methods, technical protocol characteristics, and specific changes in the ACC. Results In terms of morphology, a decrease in gray matter volume and cortical thickness was observed along with an increase in local gyrification index. In terms of function, functional connectivity (FC) within the DMN was increased. FC between the ACC and the amygdala was decreased. Higher amplitudes of low-frequency fluctuation and graph theory results, including connectivity strength, clustering coefficient, and local efficiency, were detected. In terms of neurotransmitter changes, the concentrations of glutamate increased along with a decrease in gamma-aminobutyric acid, providing a rational explanation for abdominal pain. These changes may be attributed to stress, pain, and negative emotions, as well as changes in gut microbiota. Conclusions For patients with CD, the ACC demonstrates structural, functional, and metabolic changes. In terms of clinical findings, the ACC plays an important role in the onset of depression/anxiety and abdominal pain. Therefore, successful modulation of this pathway may guide treatment." @default.
• W3116996811 created "2021-01-05" @default.
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• W3116996811 date "2020-12-12" @default.
• W3116996811 modified "2023-10-16" @default.
• W3116996811 title "Changes in the anterior cingulate cortex in Crohn’s disease: A neuroimaging perspective" @default.
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• W3116996811 doi "https://doi.org/10.1002/brb3.2003" @default.
• W3116996811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7994700" @default.
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• W3116996811 hasPublicationYear "2020" @default.
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