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- W3117081069 endingPage "108537" @default.
- W3117081069 startingPage "108537" @default.
- W3117081069 abstract "Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning and correlates with enhanced temporal precision of motor initiation. These results suggest that both simple spikes and complex spikes govern sensory-driven motor initiation: simple spikes modulate its latency, and complex spikes refine its temporal precision, providing specific cellular substrates for cerebellar sensorimotor control." @default.
- W3117081069 created "2021-01-05" @default.
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- W3117081069 date "2020-12-01" @default.
- W3117081069 modified "2023-10-12" @default.
- W3117081069 title "Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation" @default.
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- W3117081069 doi "https://doi.org/10.1016/j.celrep.2020.108537" @default.
- W3117081069 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7773552" @default.
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