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- W3117083396 abstract "Pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, is an extremely lethal disease due to late diagnosis, aggressiveness and lack of effective therapies. Considering its intrinsic heterogeneity, patient stratification models based on transcriptomic and genomic signatures, with partially overlapping subgroups, have been established. Besides molecular alterations, PDAC tumours show a strong desmoplastic response, resulting in profound metabolic reprogramming involving increased glucose and amino acid consumption, as well as lipid scavenging and biosynthesis. Interestingly, recent works have also revealed the existence of metabolic subtypes with differential prognosis within PDAC, which correlated to defined molecular subclasses in patients: lipogenic subtype correlated with a classical/progenitor signature, while glycolytic tumours associated with the highly aggressive basal/squamous profile. Bioinformatic analyses have demonstrated that the representative genes of each metabolic subtype are up-regulated in PDAC samples and predict patient survival. This suggests a relationship between the genetic signature, metabolic profile, and aggressiveness of the tumour. Considering all this, defining metabolic subtypes represents a clear opportunity for patient stratification considering tumour functional behaviour independently of their mutational background." @default.
- W3117083396 created "2021-01-05" @default.
- W3117083396 creator A5037568446 @default.
- W3117083396 creator A5038357053 @default.
- W3117083396 creator A5058667374 @default.
- W3117083396 creator A5073891040 @default.
- W3117083396 date "2020-12-21" @default.
- W3117083396 modified "2023-10-16" @default.
- W3117083396 title "Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification" @default.
- W3117083396 cites W1497915798 @default.
- W3117083396 cites W1775874433 @default.
- W3117083396 cites W1808138581 @default.
- W3117083396 cites W1892036645 @default.
- W3117083396 cites W1940824108 @default.
- W3117083396 cites W1963832813 @default.
- W3117083396 cites W1977773843 @default.
- W3117083396 cites W1987313243 @default.
- W3117083396 cites W2008054544 @default.
- W3117083396 cites W2010109455 @default.
- W3117083396 cites W2014349355 @default.
- W3117083396 cites W2014988241 @default.
- W3117083396 cites W2015012139 @default.
- W3117083396 cites W2021183081 @default.
- W3117083396 cites W2031505107 @default.
- W3117083396 cites W2034893372 @default.
- W3117083396 cites W2039210293 @default.
- W3117083396 cites W2061772840 @default.
- W3117083396 cites W2068013009 @default.
- W3117083396 cites W2069269337 @default.
- W3117083396 cites W2069376956 @default.
- W3117083396 cites W2081681778 @default.
- W3117083396 cites W2088441464 @default.
- W3117083396 cites W2102322990 @default.
- W3117083396 cites W2106664677 @default.
- W3117083396 cites W2114108194 @default.
- W3117083396 cites W2116034665 @default.
- W3117083396 cites W2117064395 @default.
- W3117083396 cites W2117692326 @default.
- W3117083396 cites W2132132957 @default.
- W3117083396 cites W2143036691 @default.
- W3117083396 cites W2154790710 @default.
- W3117083396 cites W2175990741 @default.
- W3117083396 cites W2180956285 @default.
- W3117083396 cites W2232697670 @default.
- W3117083396 cites W2280923709 @default.
- W3117083396 cites W2285093314 @default.
- W3117083396 cites W2315298586 @default.
- W3117083396 cites W2316733897 @default.
- W3117083396 cites W2319323237 @default.
- W3117083396 cites W2338926918 @default.
- W3117083396 cites W2516006356 @default.
- W3117083396 cites W2522179897 @default.
- W3117083396 cites W2531519209 @default.
- W3117083396 cites W2531887049 @default.
- W3117083396 cites W2539120393 @default.
- W3117083396 cites W2568414132 @default.
- W3117083396 cites W2580357941 @default.
- W3117083396 cites W2590889086 @default.
- W3117083396 cites W2683486796 @default.
- W3117083396 cites W2726164542 @default.
- W3117083396 cites W2734389309 @default.
- W3117083396 cites W2747955726 @default.
- W3117083396 cites W2748710555 @default.
- W3117083396 cites W2763966161 @default.
- W3117083396 cites W2769776705 @default.
- W3117083396 cites W2771729549 @default.
- W3117083396 cites W2776190850 @default.
- W3117083396 cites W2783872613 @default.
- W3117083396 cites W2785043177 @default.
- W3117083396 cites W2787497429 @default.
- W3117083396 cites W2792110902 @default.
- W3117083396 cites W2792793299 @default.
- W3117083396 cites W2796192631 @default.
- W3117083396 cites W2799673576 @default.
- W3117083396 cites W2803273701 @default.
- W3117083396 cites W2807140344 @default.
- W3117083396 cites W2902445190 @default.
- W3117083396 cites W2910033560 @default.
- W3117083396 cites W2923459819 @default.
- W3117083396 cites W2929803328 @default.
- W3117083396 cites W2948161138 @default.
- W3117083396 cites W2948368848 @default.
- W3117083396 cites W2950875093 @default.
- W3117083396 cites W2953338815 @default.
- W3117083396 cites W2968934833 @default.
- W3117083396 cites W2971665889 @default.
- W3117083396 cites W2977170998 @default.
- W3117083396 cites W2979539500 @default.
- W3117083396 cites W2981894418 @default.
- W3117083396 cites W2982288037 @default.
- W3117083396 cites W2989720538 @default.
- W3117083396 cites W2990470129 @default.
- W3117083396 cites W2999027176 @default.
- W3117083396 cites W2999372930 @default.
- W3117083396 cites W3002203823 @default.
- W3117083396 cites W3010534550 @default.
- W3117083396 cites W3019567338 @default.
- W3117083396 cites W3039702151 @default.