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• W3117197037 abstract "Elevated levels of low-density lipoprotein cholesterol (LDL-C) are causal to atherosclerosis and, thus, the reduction of LDL-C represents a major objective for the prevention of cardiovascular disease. Aim of this review is to provide an overview on novel strategies to lower LDL-C.Although inhibiting liver cholesterol biosynthesis by statins is used as the main therapeutic approach to increase hepatic LDL-receptor expression and lower plasma cholesterol levels, novel insights into lipid and lipoprotein biology have led to the development of additional lipid-lowering therapies that can be used in combination with or as an alternative to statins in patients with statin-intolerance. New approaches include bempedoic acid, proprotein convertase subtilisin/kexin type 9 inhibitors, and angiopoietin-like protein 3 inhibitors.In the last decade, several novel therapeutic approaches have been tested and some of them have been approved as lipid-lowering agents. Some drugs are already available in clinical practice, whereas others are at late stages of development." @default.
• W3117197037 created "2021-01-05" @default.
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• W3117197037 date "2020-12-25" @default.
• W3117197037 modified "2023-10-12" @default.
• W3117197037 title "Recent insights into low-density lipoprotein metabolism and therapy" @default.
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• W3117197037 doi "https://doi.org/10.1097/mco.0000000000000727" @default.
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