FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117236054> ?p ?o ?g. }

• W3117236054 endingPage "101990" @default.
• W3117236054 startingPage "101990" @default.
• W3117236054 abstract "Hydroxychloroquine (HCQ) is a well-known anti-inflammatory drug but is also known as an anti-inflammatory drug. Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Anti-PD1 therapy-sensitive tumor lines MC38, CT26, and RIL-175 were used to investigate the impact of HCQ on anti-PD1 therapy efficacy. In vitro assays demonstrated that HCQ directly inhibited tumor cell growth in all the tested tumor cell lines. HCQ treatment impaired both antigen-specific and nonspecific T-cell production of TNFα and IFNγ in vitro and in vivo. Importantly, in all the three tumor models, HCQ treatment significantly impaired the response to anti-PD1 treatment, accompanying diminished in vivo T-cell activation and reduced tumor-infiltrating, antigen-specific CD8+ T cells. This study shows that HCQ treatment can result in immunotherapy failure due to its immunosuppressive effects that offset both increased MHC-I expression by tumor cell and direct cytotoxicity." @default.
• W3117236054 created "2021-01-05" @default.
• W3117236054 creator A5008922508 @default.
• W3117236054 creator A5035107889 @default.
• W3117236054 creator A5036660016 @default.
• W3117236054 creator A5057000867 @default.
• W3117236054 creator A5061217689 @default.
• W3117236054 creator A5061786596 @default.
• W3117236054 creator A5078051883 @default.
• W3117236054 creator A5078103351 @default.
• W3117236054 creator A5080512785 @default.
• W3117236054 date "2021-01-01" @default.
• W3117236054 modified "2023-10-18" @default.
• W3117236054 title "Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models" @default.
• W3117236054 cites W1641310843 @default.
• W3117236054 cites W1985181188 @default.
• W3117236054 cites W1992786201 @default.
• W3117236054 cites W2006937936 @default.
• W3117236054 cites W2014359324 @default.
• W3117236054 cites W2018872699 @default.
• W3117236054 cites W2032109805 @default.
• W3117236054 cites W2084838499 @default.
• W3117236054 cites W2095998776 @default.
• W3117236054 cites W2119770893 @default.
• W3117236054 cites W2127377435 @default.
• W3117236054 cites W2133000461 @default.
• W3117236054 cites W2461276669 @default.
• W3117236054 cites W2516058590 @default.
• W3117236054 cites W2523826139 @default.
• W3117236054 cites W2535234134 @default.
• W3117236054 cites W2587002135 @default.
• W3117236054 cites W2595011831 @default.
• W3117236054 cites W2796190150 @default.
• W3117236054 cites W2802078831 @default.
• W3117236054 cites W2809833956 @default.
• W3117236054 cites W2810037075 @default.
• W3117236054 cites W2887577080 @default.
• W3117236054 cites W2898826594 @default.
• W3117236054 cites W2920097475 @default.
• W3117236054 cites W2925270112 @default.
• W3117236054 cites W2982049472 @default.
• W3117236054 cites W3004709581 @default.
• W3117236054 cites W3005512912 @default.
• W3117236054 cites W3009885589 @default.
• W3117236054 cites W3010673910 @default.
• W3117236054 cites W3010930696 @default.
• W3117236054 cites W3013125498 @default.
• W3117236054 cites W3020766569 @default.
• W3117236054 doi "https://doi.org/10.1016/j.isci.2020.101990" @default.
• W3117236054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7807148" @default.
• W3117236054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33490900" @default.
• W3117236054 hasPublicationYear "2021" @default.
• W3117236054 type Work @default.
• W3117236054 sameAs 3117236054 @default.
• W3117236054 citedByCount "10" @default.
• W3117236054 countsByYear W31172360542021 @default.
• W3117236054 countsByYear W31172360542022 @default.
• W3117236054 countsByYear W31172360542023 @default.
• W3117236054 crossrefType "journal-article" @default.
• W3117236054 hasAuthorship W3117236054A5008922508 @default.
• W3117236054 hasAuthorship W3117236054A5035107889 @default.
• W3117236054 hasAuthorship W3117236054A5036660016 @default.
• W3117236054 hasAuthorship W3117236054A5057000867 @default.
• W3117236054 hasAuthorship W3117236054A5061217689 @default.
• W3117236054 hasAuthorship W3117236054A5061786596 @default.
• W3117236054 hasAuthorship W3117236054A5078051883 @default.
• W3117236054 hasAuthorship W3117236054A5078103351 @default.
• W3117236054 hasAuthorship W3117236054A5080512785 @default.
• W3117236054 hasBestOaLocation W31172360541 @default.
• W3117236054 hasConcept C126322002 @default.
• W3117236054 hasConcept C147483822 @default.
• W3117236054 hasConcept C150903083 @default.
• W3117236054 hasConcept C154317977 @default.
• W3117236054 hasConcept C167672396 @default.
• W3117236054 hasConcept C17991360 @default.
• W3117236054 hasConcept C185592680 @default.
• W3117236054 hasConcept C202751555 @default.
• W3117236054 hasConcept C203014093 @default.
• W3117236054 hasConcept C207001950 @default.
• W3117236054 hasConcept C2776090121 @default.
• W3117236054 hasConcept C2777701055 @default.
• W3117236054 hasConcept C2778326572 @default.
• W3117236054 hasConcept C2779123688 @default.
• W3117236054 hasConcept C2779134260 @default.
• W3117236054 hasConcept C3008058167 @default.
• W3117236054 hasConcept C502942594 @default.
• W3117236054 hasConcept C524204448 @default.
• W3117236054 hasConcept C55493867 @default.
• W3117236054 hasConcept C71924100 @default.
• W3117236054 hasConcept C86803240 @default.
• W3117236054 hasConcept C8891405 @default.
• W3117236054 hasConcept C98274493 @default.
• W3117236054 hasConceptScore W3117236054C126322002 @default.
• W3117236054 hasConceptScore W3117236054C147483822 @default.
• W3117236054 hasConceptScore W3117236054C150903083 @default.
• W3117236054 hasConceptScore W3117236054C154317977 @default.
• W3117236054 hasConceptScore W3117236054C167672396 @default.
• W3117236054 hasConceptScore W3117236054C17991360 @default.

• next