Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117284839> ?p ?o ?g. }
- W3117284839 endingPage "101152" @default.
- W3117284839 startingPage "101152" @default.
- W3117284839 abstract "FGF19 and FGF21 have shown therapeutic promise since their discovery, attested by the fact there are at least 5 assets that activate the FGFR/KLB pathway and one FGF19 analog in clinical development. We performed a detailed analyses of published preclinical and clinical data to offer insights into the mechanism of action, as well as PK/PD and efficacy data of the clinical assets. Scouring the literature, we offer mechanistic insights from preclinical data using rodents and non-human primates and pharmacodynamic data from clinical studies. The basic and applied science around endocrine FGFs has evolved exponentially over the years with FGF19 and FGF21 analogs are now entering Phase 3 clinical research." @default.
- W3117284839 created "2021-01-05" @default.
- W3117284839 creator A5059226106 @default.
- W3117284839 creator A5068454785 @default.
- W3117284839 date "2021-04-01" @default.
- W3117284839 modified "2023-10-17" @default.
- W3117284839 title "FGF19 and FGF21: In NASH we trust" @default.
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