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• W3117305607 abstract "Abstract Introduction Arterial blood gas analysis (ABG) is the gold standard test for carbon dioxide measurement. End‐tidal PCO 2 (PetCO 2 ) and transcutaneous PCO 2 (PtcCO 2 ) are noninvasive alternative methods. Objective To examine the use of PetCO 2 and PtcCO 2 as PaCO 2 surrogates in awake children. Methods A prospective observational study. Consecutive awake children in a stable condition referred to the Sleep Unit of Hospital de Pediatría Dr. J. P. Garrahan with suspected or confirmed sleep‐related respiratory disorders requiring ABG were included. PetCO 2 and PtcCO 2 were recorded simultaneously during arterial puncture. PetCO 2 and PtCO 2 values were compared with PaCO 2 . Correlation coefficient and Bland–Altman analysis were applied. The sample size was calculated considering a mean difference ≤3 mmHg as clinically acceptable. Results Sixty‐eight sample sets were obtained from 67 patients. The median age was 9.11 years (0.23–18.76). During 94.1% of the procedures patients breathed spontaneously, 30% needed multiple punctures and 92% resulted in pain. Median (IQR) PaCO 2 (mmHg) was 36.3 (31.45; 40.90), PetCO 2 33.0 (29; 39) and PtcCO 2 38.8 (32.95; 43.32). Correlation and agreement for PaCO 2 /PetCO 2 and PaCO 2 /PtcCO 2 was r = .6 and .9, and media of bias = 2.83 (−9.97; 15.64) and −1.88 (−9.01; 5.24), respectively. Hypercapnia (PaCO 2 > 45.0 mmHg) was present in 8/68 (11.8%) samples. Sensitivity, specificity, positive predictive value and negative predictive value to detect hypercapnia with PetCO 2 was 38%, 98%, 75%, and 92%, respectively, and with PtcCO 2 , 100%, 90%, 57%, and 100%, respectively. Conclusion PtcCO 2 showed better agreement with PaCO 2 than PetCO 2 but because of the wide dispersion of values, neither method can replace the gold standard. Transcutaneous CO 2 might be a good screening tool to detect hypercapnia in awake children." @default.
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• W3117305607 date "2020-12-31" @default.
• W3117305607 modified "2023-10-18" @default.
• W3117305607 title "End‐tidal CO ₂ and transcutaneous CO ₂ : Are we ready to replace arterial CO ₂ in awake children?" @default.
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• W3117305607 doi "https://doi.org/10.1002/ppul.25217" @default.
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