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- W3117653784 abstract "The hydrolytic deamination of adenosine-to-inosine (A-to-I) by RNA editing is a widespread post-transcriptional modification catalyzed by the adenosine deaminase acting on RNA (ADAR) family of proteins. ADAR-mediated RNA editing modulates cellular pathways involved in innate immunity, RNA splicing, RNA interference, and protein recoding, and has been investigated as a strategy for therapeutic intervention of genetic disorders. Despite advances in basic and translational research, the mechanisms regulating RNA editing are poorly understood. Though several trans-acting regulators of editing have been shown to modulate ADAR protein expression, previous studies have not identified factors that modulate ADAR catalytic activity. Here, we show that RNA editing increases upon intracellular acidification, and that these effects are predominantly explained by both enhanced ADAR base-flipping and deamination rate at acidic pH. We also show that the extent of RNA editing increases with the reduction in pH associated with conditions of cellular hypoxia." @default.
- W3117653784 created "2021-01-05" @default.
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- W3117653784 creator A5024536311 @default.
- W3117653784 creator A5064820122 @default.
- W3117653784 date "2021-03-15" @default.
- W3117653784 modified "2023-10-15" @default.
- W3117653784 title "Regulation of RNA editing by intracellular acidification" @default.
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- W3117653784 doi "https://doi.org/10.1093/nar/gkab157" @default.
- W3117653784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8053123" @default.
- W3117653784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33721028" @default.
- W3117653784 hasPublicationYear "2021" @default.
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