FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117654493> ?p ?o ?g. }

• W3117654493 endingPage "991" @default.
• W3117654493 startingPage "982" @default.
• W3117654493 abstract "Disease-modifying therapies provide new horizons for hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) to slow neuropathic progression. Initiating treatment at the earliest time requires biomarkers reflecting both small- and large-fiber degeneration in carriers.This study included examinations of pathology (intraepidermal nerve fiber [IENF] density), physiology (nerve conduction studies, autonomic function test, and nerve excitability), and psychophysics (thermal thresholds) in carriers to compare to healthy controls and asymptomatic diabetic patients.There were 43 carriers (44.2 ± 11.4 years, p.Ala117Ser in 42 carriers), 43 controls (43.4 ± 12.7 years) including 26 noncarrier families, and 50 asymptomatic diabetic patients (58.1 ± 9.5 years). Carriers had lower IENF densities than controls and similar densities as diabetic patients. Median nerve conduction parameters, especially distal motor latency, were the most frequent neurophysiological abnormality in carriers, could differentiate carriers from controls and diabetic patients, were correlated with IENF densities in carriers but not in controls and diabetic patients, and were correlated with nerve excitability parameters in carriers but not in controls. Fifteen carriers (34.9%) with electrophysiological evidence of median nerve entrapment at the wrist had lower IENF densities and more abnormal conduction parameters than carriers without. We defined nerve dysfunction index-the ratio of median distal motor latency to IENF density-which differentiated carriers from controls.In late-onset ATTRv-PN carriers with predominant p.Ala117Ser, median conduction parameters were the most common neurophysiological abnormalities and served as surrogate signatures of small- and large-fiber impairment. Combination of median distal motor latency and IENF density can reflect early neuropathy in carriers." @default.
• W3117654493 created "2021-01-05" @default.
• W3117654493 creator A5000758877 @default.
• W3117654493 creator A5006737817 @default.
• W3117654493 creator A5008537896 @default.
• W3117654493 creator A5017703825 @default.
• W3117654493 creator A5017810039 @default.
• W3117654493 creator A5020774462 @default.
• W3117654493 creator A5024516915 @default.
• W3117654493 creator A5053486723 @default.
• W3117654493 creator A5067455070 @default.
• W3117654493 creator A5070394837 @default.
• W3117654493 creator A5070439625 @default.
• W3117654493 date "2021-01-09" @default.
• W3117654493 modified "2023-09-27" @default.
• W3117654493 title "Early changes of nerve integrity in preclinical carriers of hereditary transthyretin Ala117Ser amyloidosis with polyneuropathy" @default.
• W3117654493 cites W1789722239 @default.
• W3117654493 cites W1916870587 @default.
• W3117654493 cites W1980276147 @default.
• W3117654493 cites W2014789039 @default.
• W3117654493 cites W2044723581 @default.
• W3117654493 cites W2049505629 @default.
• W3117654493 cites W2076832251 @default.
• W3117654493 cites W2092593347 @default.
• W3117654493 cites W2099615506 @default.
• W3117654493 cites W2100817237 @default.
• W3117654493 cites W2100986954 @default.
• W3117654493 cites W2101934278 @default.
• W3117654493 cites W2123522220 @default.
• W3117654493 cites W2131953429 @default.
• W3117654493 cites W2131999691 @default.
• W3117654493 cites W2135360928 @default.
• W3117654493 cites W2147305697 @default.
• W3117654493 cites W2148373528 @default.
• W3117654493 cites W2151835611 @default.
• W3117654493 cites W2152985509 @default.
• W3117654493 cites W2165527956 @default.
• W3117654493 cites W2188137227 @default.
• W3117654493 cites W2198815350 @default.
• W3117654493 cites W2317504286 @default.
• W3117654493 cites W2495787001 @default.
• W3117654493 cites W2544911416 @default.
• W3117654493 cites W2606290957 @default.
• W3117654493 cites W2612878441 @default.
• W3117654493 cites W2621573584 @default.
• W3117654493 cites W2788864065 @default.
• W3117654493 cites W2809989268 @default.
• W3117654493 cites W2810909862 @default.
• W3117654493 cites W2912867338 @default.
• W3117654493 cites W2914529480 @default.
• W3117654493 cites W2920082779 @default.
• W3117654493 cites W2938413156 @default.
• W3117654493 cites W2952789707 @default.
• W3117654493 cites W3087036289 @default.
• W3117654493 cites W31207847 @default.
• W3117654493 cites W4254402012 @default.
• W3117654493 doi "https://doi.org/10.1111/ene.14698" @default.
• W3117654493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33369810" @default.
• W3117654493 hasPublicationYear "2021" @default.
• W3117654493 type Work @default.
• W3117654493 sameAs 3117654493 @default.
• W3117654493 citedByCount "8" @default.
• W3117654493 countsByYear W31176544932021 @default.
• W3117654493 countsByYear W31176544932022 @default.
• W3117654493 countsByYear W31176544932023 @default.
• W3117654493 crossrefType "journal-article" @default.
• W3117654493 hasAuthorship W3117654493A5000758877 @default.
• W3117654493 hasAuthorship W3117654493A5006737817 @default.
• W3117654493 hasAuthorship W3117654493A5008537896 @default.
• W3117654493 hasAuthorship W3117654493A5017703825 @default.
• W3117654493 hasAuthorship W3117654493A5017810039 @default.
• W3117654493 hasAuthorship W3117654493A5020774462 @default.
• W3117654493 hasAuthorship W3117654493A5024516915 @default.
• W3117654493 hasAuthorship W3117654493A5053486723 @default.
• W3117654493 hasAuthorship W3117654493A5067455070 @default.
• W3117654493 hasAuthorship W3117654493A5070394837 @default.
• W3117654493 hasAuthorship W3117654493A5070439625 @default.
• W3117654493 hasConcept C105702510 @default.
• W3117654493 hasConcept C126322002 @default.
• W3117654493 hasConcept C134018914 @default.
• W3117654493 hasConcept C137916694 @default.
• W3117654493 hasConcept C142724271 @default.
• W3117654493 hasConcept C164705383 @default.
• W3117654493 hasConcept C179253579 @default.
• W3117654493 hasConcept C2775892965 @default.
• W3117654493 hasConcept C2775912687 @default.
• W3117654493 hasConcept C2776823239 @default.
• W3117654493 hasConcept C2777910003 @default.
• W3117654493 hasConcept C2779658331 @default.
• W3117654493 hasConcept C2994188736 @default.
• W3117654493 hasConcept C555293320 @default.
• W3117654493 hasConcept C71924100 @default.
• W3117654493 hasConceptScore W3117654493C105702510 @default.
• W3117654493 hasConceptScore W3117654493C126322002 @default.
• W3117654493 hasConceptScore W3117654493C134018914 @default.
• W3117654493 hasConceptScore W3117654493C137916694 @default.
• W3117654493 hasConceptScore W3117654493C142724271 @default.
• W3117654493 hasConceptScore W3117654493C164705383 @default.

• next