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- W3117665719 endingPage "5813" @default.
- W3117665719 startingPage "5813" @default.
- W3117665719 abstract "Pancreatic cancer belongs to the most aggressive group of cancers, with very poor prognosis. Therefore, there is an important need to find more potent drugs that could deliver an improved therapeutic approach. In the current study we searched for selective and effective caffeic acid derivatives. For this purpose, we analyzed twelve compounds and evaluated their in vitro cytotoxic activity against two human pancreatic cancer cell lines, along with a control, normal fibroblast cell line, by the classic MTT assay. Six out of twelve tested caffeic acid derivatives showed a desirable effect. To improve the therapeutic efficacy of such active compounds, we developed a formulation where caffeic acid derivative (7) was encapsulated into liposomes composed of soybean phosphatidylcholine and DSPE-PEG2000. Subsequently, we analyzed the properties of this formulation in terms of basic physical parameters (such as size, zeta potential, stability at 4 °C and morphology), hemolytic and cytotoxic activity and cellular uptake. Overall, the liposomal formulation was found to be stable, non-hemolytic and had activity against pancreatic cancer cells (IC50 19.44 µM and 24.3 µM, towards AsPC1 and BxPC3 cells, respectively) with less toxicity against normal fibroblasts. This could represent a promising alternative to currently available treatment options." @default.
- W3117665719 created "2021-01-05" @default.
- W3117665719 creator A5021806327 @default.
- W3117665719 creator A5025262865 @default.
- W3117665719 creator A5033154140 @default.
- W3117665719 creator A5055541717 @default.
- W3117665719 creator A5055867374 @default.
- W3117665719 creator A5063136001 @default.
- W3117665719 date "2020-12-19" @default.
- W3117665719 modified "2023-10-14" @default.
- W3117665719 title "Evaluation of the In Vitro Cytotoxic Activity of Caffeic Acid Derivatives and Liposomal Formulation against Pancreatic Cancer Cell Lines" @default.
- W3117665719 cites W1558785724 @default.
- W3117665719 cites W1716112043 @default.
- W3117665719 cites W1852597513 @default.
- W3117665719 cites W1925321906 @default.
- W3117665719 cites W1968812902 @default.
- W3117665719 cites W1971596240 @default.
- W3117665719 cites W1972057863 @default.
- W3117665719 cites W1974797973 @default.
- W3117665719 cites W1978029175 @default.
- W3117665719 cites W1978272694 @default.
- W3117665719 cites W1978763455 @default.
- W3117665719 cites W1998432440 @default.
- W3117665719 cites W2001658868 @default.
- W3117665719 cites W2010185799 @default.
- W3117665719 cites W2014086416 @default.
- W3117665719 cites W2017569244 @default.
- W3117665719 cites W2028873536 @default.
- W3117665719 cites W2031986820 @default.
- W3117665719 cites W2033197135 @default.
- W3117665719 cites W2062172769 @default.
- W3117665719 cites W2062878623 @default.
- W3117665719 cites W2066411725 @default.
- W3117665719 cites W2070088525 @default.
- W3117665719 cites W2086246413 @default.
- W3117665719 cites W2094787662 @default.
- W3117665719 cites W2102516914 @default.
- W3117665719 cites W2114918609 @default.
- W3117665719 cites W2122350971 @default.
- W3117665719 cites W2137816700 @default.
- W3117665719 cites W2142225089 @default.
- W3117665719 cites W2147026669 @default.
- W3117665719 cites W2147365776 @default.
- W3117665719 cites W2150516757 @default.
- W3117665719 cites W2151047906 @default.
- W3117665719 cites W2165596895 @default.
- W3117665719 cites W2167103908 @default.
- W3117665719 cites W2167741612 @default.
- W3117665719 cites W2187976253 @default.
- W3117665719 cites W2263019937 @default.
- W3117665719 cites W2293358766 @default.
- W3117665719 cites W2345822778 @default.
- W3117665719 cites W2416807224 @default.
- W3117665719 cites W2418702816 @default.
- W3117665719 cites W2497208646 @default.
- W3117665719 cites W2518509288 @default.
- W3117665719 cites W2531714473 @default.
- W3117665719 cites W2556205587 @default.
- W3117665719 cites W2557531334 @default.
- W3117665719 cites W2558248833 @default.
- W3117665719 cites W2600791752 @default.
- W3117665719 cites W2683486796 @default.
- W3117665719 cites W2698746343 @default.
- W3117665719 cites W2741560216 @default.
- W3117665719 cites W2744322882 @default.
- W3117665719 cites W2762341360 @default.
- W3117665719 cites W2765634063 @default.
- W3117665719 cites W2765850855 @default.
- W3117665719 cites W2772670881 @default.
- W3117665719 cites W2791161745 @default.
- W3117665719 cites W2793979211 @default.
- W3117665719 cites W2798061340 @default.
- W3117665719 cites W2807222959 @default.
- W3117665719 cites W2809143332 @default.
- W3117665719 cites W2883635467 @default.
- W3117665719 cites W2883828582 @default.
- W3117665719 cites W2884616676 @default.
- W3117665719 cites W2885738414 @default.
- W3117665719 cites W2889501876 @default.
- W3117665719 cites W2889990912 @default.
- W3117665719 cites W2892737716 @default.
- W3117665719 cites W2898571891 @default.
- W3117665719 cites W2904466466 @default.
- W3117665719 cites W2911651446 @default.
- W3117665719 cites W2912429260 @default.
- W3117665719 cites W2917091045 @default.
- W3117665719 cites W2917919815 @default.
- W3117665719 cites W2940439131 @default.
- W3117665719 cites W2945349403 @default.
- W3117665719 cites W2952519293 @default.
- W3117665719 cites W2969032330 @default.
- W3117665719 cites W2969377001 @default.
- W3117665719 cites W2992083347 @default.
- W3117665719 cites W2995662817 @default.
- W3117665719 cites W2997572324 @default.
- W3117665719 cites W3003385877 @default.
- W3117665719 cites W3004060585 @default.
- W3117665719 cites W3006638330 @default.