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- W3117788478 abstract "• A novel approach to prepare supramolecular silk fibroin-based hydrogel. • The hydrogel showed good self-healing, syringeability, and biocompatibility. • The hydrogel exhibited a sustained drug release for hydrophobic drug curcumin. • The hydrogel showed enhanced wound healing efficiency in vivo . Silk fibroin (SF) based hydrogels possess great potential in wound healing. However, they have limitations as wound dressings, such as long-gelation time, high temperature or organic solvent-assisted treatment, and lack of self-healing property. In this study, a supramolecular hydrogel based on SF, acryloyl- β -cyclodextrin (Ac-CD) and 2-hydroxyethyl acrylate was developed through a facile method by photo-polymerization of acrylate under UV irradiation, and showed enhanced performance as wound dressing than commercial dressing. This SF based hydrogel was confirmed to be dually crosslinked by host–guest interaction and hydrophobic β -sheet conformation, and demonstrated improved mechanical properties, long-term stability, rapid self-healing behavior, injectability, and good biocompatibility, benefiting its application as wound dressing. Moreover, as a drug carrier owing abundant CDs, the hydrophobic drug curcumin with antioxidant and anti-inflammatory activity was loaded in SF-based hydrogel, accompanying with a controlled and sustained release profile, therewith boosting better wound healing performance with generating higher granulation tissue thickness, collagen disposition, upregulating vascular endothelial growth factor (VEGF), and decreasing inflammatory response in a full-thickness skin defect model. In conclusion, this novel self-healing SF-based hydrogel is of great value in wound healing and enriches the fabrication methodology of SF-based self-healing biomaterials as well." @default.
- W3117788478 created "2021-01-05" @default.
- W3117788478 creator A5012502449 @default.
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- W3117788478 creator A5087592842 @default.
- W3117788478 date "2021-08-01" @default.
- W3117788478 modified "2023-10-05" @default.
- W3117788478 title "Novel supramolecular self-healing silk fibroin-based hydrogel via host–guest interaction as wound dressing to enhance wound healing" @default.
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- W3117788478 doi "https://doi.org/10.1016/j.cej.2020.128278" @default.
- W3117788478 hasPublicationYear "2021" @default.
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