Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117798260> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3117798260 abstract "Efforts to treat chronic diseases are often obstructed by the complexity of the biological mechanisms supporting pathology. Here, we apply a novel method for discrete logical modeling of biological systems to the problem of infectious exacerbations in chronic obstructive pulmonary disease (COPD), using data from human clinical studies to constrain the selection of decisional logic parameters. We obtained two candidate models satisfactorily adhering to the available data. A predicted resting state with no activation of inflammatory markers was supported natively in one model, and could be induced following onset of an exacerbation episode in either model by applying targeted suppression of IL-4 concurrently with at least one additional inflammatory marker including IL-IB. Recapitulating a failed clinical trial of anakinra, suppression of IL-IB alone was not predicted to be sufficient. Instead, these results suggest that the efficacy of IL-IB suppression in the treatment of COPD might be improved by the added concurrent suppression of IL-4 and CCL4 or IL-4 and IL-17A." @default.
- W3117798260 created "2021-01-05" @default.
- W3117798260 creator A5015262975 @default.
- W3117798260 creator A5052915205 @default.
- W3117798260 creator A5059374169 @default.
- W3117798260 creator A5063759058 @default.
- W3117798260 creator A5067232021 @default.
- W3117798260 creator A5088129571 @default.
- W3117798260 creator A5091405717 @default.
- W3117798260 date "2020-10-01" @default.
- W3117798260 modified "2023-10-17" @default.
- W3117798260 title "Hacking the Immune Response to Infection in Chronic Obstructive Pulmonary Disease" @default.
- W3117798260 cites W149946109 @default.
- W3117798260 cites W1760281680 @default.
- W3117798260 cites W1964231120 @default.
- W3117798260 cites W1973530626 @default.
- W3117798260 cites W2002726093 @default.
- W3117798260 cites W2009478129 @default.
- W3117798260 cites W2010650802 @default.
- W3117798260 cites W2033981208 @default.
- W3117798260 cites W2042334684 @default.
- W3117798260 cites W2059035667 @default.
- W3117798260 cites W2140601463 @default.
- W3117798260 cites W2159482845 @default.
- W3117798260 cites W2265368852 @default.
- W3117798260 cites W2314900475 @default.
- W3117798260 cites W2334039158 @default.
- W3117798260 cites W2416403854 @default.
- W3117798260 cites W2484370266 @default.
- W3117798260 cites W2619343165 @default.
- W3117798260 cites W2742869577 @default.
- W3117798260 cites W2767891136 @default.
- W3117798260 cites W2787229753 @default.
- W3117798260 cites W2793507902 @default.
- W3117798260 cites W2884325401 @default.
- W3117798260 cites W2909497687 @default.
- W3117798260 cites W2922816079 @default.
- W3117798260 cites W2923424733 @default.
- W3117798260 doi "https://doi.org/10.1109/bibe50027.2020.00143" @default.
- W3117798260 hasPublicationYear "2020" @default.
- W3117798260 type Work @default.
- W3117798260 sameAs 3117798260 @default.
- W3117798260 citedByCount "1" @default.
- W3117798260 countsByYear W31177982602022 @default.
- W3117798260 crossrefType "proceedings-article" @default.
- W3117798260 hasAuthorship W3117798260A5015262975 @default.
- W3117798260 hasAuthorship W3117798260A5052915205 @default.
- W3117798260 hasAuthorship W3117798260A5059374169 @default.
- W3117798260 hasAuthorship W3117798260A5063759058 @default.
- W3117798260 hasAuthorship W3117798260A5067232021 @default.
- W3117798260 hasAuthorship W3117798260A5088129571 @default.
- W3117798260 hasAuthorship W3117798260A5091405717 @default.
- W3117798260 hasConcept C126322002 @default.
- W3117798260 hasConcept C142724271 @default.
- W3117798260 hasConcept C203014093 @default.
- W3117798260 hasConcept C2776780178 @default.
- W3117798260 hasConcept C2776914184 @default.
- W3117798260 hasConcept C2777014857 @default.
- W3117798260 hasConcept C2779134260 @default.
- W3117798260 hasConcept C2781228260 @default.
- W3117798260 hasConcept C2992779976 @default.
- W3117798260 hasConcept C535046627 @default.
- W3117798260 hasConcept C71924100 @default.
- W3117798260 hasConcept C8891405 @default.
- W3117798260 hasConceptScore W3117798260C126322002 @default.
- W3117798260 hasConceptScore W3117798260C142724271 @default.
- W3117798260 hasConceptScore W3117798260C203014093 @default.
- W3117798260 hasConceptScore W3117798260C2776780178 @default.
- W3117798260 hasConceptScore W3117798260C2776914184 @default.
- W3117798260 hasConceptScore W3117798260C2777014857 @default.
- W3117798260 hasConceptScore W3117798260C2779134260 @default.
- W3117798260 hasConceptScore W3117798260C2781228260 @default.
- W3117798260 hasConceptScore W3117798260C2992779976 @default.
- W3117798260 hasConceptScore W3117798260C535046627 @default.
- W3117798260 hasConceptScore W3117798260C71924100 @default.
- W3117798260 hasConceptScore W3117798260C8891405 @default.
- W3117798260 hasFunder F4320307779 @default.
- W3117798260 hasLocation W31177982601 @default.
- W3117798260 hasOpenAccess W3117798260 @default.
- W3117798260 hasPrimaryLocation W31177982601 @default.
- W3117798260 hasRelatedWork W11484849 @default.
- W3117798260 hasRelatedWork W13925909 @default.
- W3117798260 hasRelatedWork W15726864 @default.
- W3117798260 hasRelatedWork W16080818 @default.
- W3117798260 hasRelatedWork W16227375 @default.
- W3117798260 hasRelatedWork W16816081 @default.
- W3117798260 hasRelatedWork W17406315 @default.
- W3117798260 hasRelatedWork W19802236 @default.
- W3117798260 hasRelatedWork W204449 @default.
- W3117798260 hasRelatedWork W20714265 @default.
- W3117798260 isParatext "false" @default.
- W3117798260 isRetracted "false" @default.
- W3117798260 magId "3117798260" @default.
- W3117798260 workType "article" @default.