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- W3117831280 abstract "Objective By using magnetic resonance spectroscopy (MRS) to determine metabolite content of growing nfollicle in patients with polycystic ovary syndrome (PCOS) receiving recombinant FSH, clomiphene citrate (CC) or aromatase inhibitor (AI) for ovarian stimulation. Material and methods 30 patients diagnosed with PCOS and infertility and scheduled for ovarian stimulation were divided into 3 equal groups according to the drugs they took as follows: rFSH (n: 10), or CC (n: 10), or AI (n = 10). Five fertile cases were determined as the control group. When the follicle diameters reached 16-18 mm in each group, patients were directed to the MRS and the metabolite content of a dominant follicle was analyzed. N-acetylaspartate (NAA), lactate (Lac), creatine (Cr), and choline (Cho) metabolite levels determined in the spectrum were measured in ppm. Results Approximately 3-fold decrease in dominant follicle Cho content was found in patients receiving CC compared to control subjects. Similarly, the dominant follicle Cho intensities of patients given rFSH and AI were noted to be significantly higher than those who received CC. Only dominant follicle lactate levels of the patients who received CC were found to be significantly higher than the other groups. Cr peak intensities of patients receiving CC were found to be approximately 3 times less than control subjects. Cr signal intensity was significantly higher in patients receiving rFSH or AI than in patients receiving clomiphene. While 2 patients became pregnant in the CC group, 3 patients in the AI group and 5 patients in the rFSH group became pregnant. The main metabolites detected in patients who conceived in each group were Cho and Cr. In cases who could not conceive, while lactate and lipid signals increased, Cho and Cr signals decreased. Conclusion Unlike CC, ovulation stimulation with rFSH or AI does not alter dominant follicle metabolite content. Developmental capacity of growing egg can be determined non-invasively with MRS." @default.
- W3117831280 created "2021-01-05" @default.
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- W3117831280 date "2021-05-28" @default.
- W3117831280 modified "2023-10-05" @default.
- W3117831280 title "Ovarian stimulation drugs alter the metabolite content of the growing follicle: in vivo spectroscopic evaluation of follicle fluid" @default.
- W3117831280 doi "https://doi.org/10.4274/jtgga.galenos.2020.2020.0104" @default.
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