FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117871953> ?p ?o ?g. }

• W3117871953 endingPage "1177" @default.
• W3117871953 startingPage "1166" @default.
• W3117871953 abstract "Abstract Pathological hypertrophy contributes to heart failure and there is not quite effective treatment to invert this process. Isosteviol has been shown to protect the heart against ischaemia‐reperfusion injury and isoproterenol‐induced cardiac hypertrophy, but its effect on pressure overload‐induced cardiac hypertrophy is still unknown. Pressure overload induced by transverse aortic constriction (TAC) causes cardiac hypertrophy in rats to mimic the pathological condition in human. This study examined the effects of isosteviol sodium (STVNa) on cardiac hypertrophy by the TAC model and cellular assays in vitro. Cardiac function test, electrocardiogram analysis and histological analysis were conducted. The effects of STVNa on calcium transient of the adult rat ventricular cells and the proliferation of neonatal rat cardiac fibroblasts were also studied in vitro. Cardiac hypertrophy was observed after 3‐week TAC while the extensive cardiac dysfunction and electronic remodelling were observed after 9‐week TAC. Both STVNa and sildenafil (positive drug) treatment reversed the two process, but STVNa appeared to be more superior in some aspects and did not change calcium transient considerably. STVNa also reversed TAC‐induced cardiac fibrosis in vivo and TGF‐β1‐induced fibroblast proliferation in vitro. Moreover, STVNa, but not sildenafil, reversed impairment of the autonomic nervous system induced by 9‐week TAC." @default.
• W3117871953 created "2021-01-05" @default.
• W3117871953 creator A5000409712 @default.
• W3117871953 creator A5001549014 @default.
• W3117871953 creator A5015174193 @default.
• W3117871953 creator A5048279362 @default.
• W3117871953 creator A5062448359 @default.
• W3117871953 creator A5065101788 @default.
• W3117871953 creator A5077873585 @default.
• W3117871953 date "2020-12-17" @default.
• W3117871953 modified "2023-09-24" @default.
• W3117871953 title "The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat" @default.
• W3117871953 cites W138609828 @default.
• W3117871953 cites W189074344 @default.
• W3117871953 cites W1968647871 @default.
• W3117871953 cites W1970277713 @default.
• W3117871953 cites W1974796215 @default.
• W3117871953 cites W1976226569 @default.
• W3117871953 cites W1978545009 @default.
• W3117871953 cites W1979363352 @default.
• W3117871953 cites W1992728554 @default.
• W3117871953 cites W2001333805 @default.
• W3117871953 cites W2002387279 @default.
• W3117871953 cites W2006273510 @default.
• W3117871953 cites W2014396492 @default.
• W3117871953 cites W2024784027 @default.
• W3117871953 cites W2025620168 @default.
• W3117871953 cites W2029794453 @default.
• W3117871953 cites W2034631735 @default.
• W3117871953 cites W2035192492 @default.
• W3117871953 cites W2048078392 @default.
• W3117871953 cites W2052039979 @default.
• W3117871953 cites W2052780003 @default.
• W3117871953 cites W2056544128 @default.
• W3117871953 cites W2087610485 @default.
• W3117871953 cites W2094160006 @default.
• W3117871953 cites W2099163211 @default.
• W3117871953 cites W2104483699 @default.
• W3117871953 cites W2110648659 @default.
• W3117871953 cites W2112636786 @default.
• W3117871953 cites W2120724291 @default.
• W3117871953 cites W2122180603 @default.
• W3117871953 cites W2126271215 @default.
• W3117871953 cites W2132250523 @default.
• W3117871953 cites W2132479140 @default.
• W3117871953 cites W2135958771 @default.
• W3117871953 cites W2136429434 @default.
• W3117871953 cites W2138861048 @default.
• W3117871953 cites W2143077915 @default.
• W3117871953 cites W2145960531 @default.
• W3117871953 cites W2152748654 @default.
• W3117871953 cites W2159259090 @default.
• W3117871953 cites W2181968881 @default.
• W3117871953 cites W2185101657 @default.
• W3117871953 cites W2328740330 @default.
• W3117871953 cites W2974763282 @default.
• W3117871953 cites W2999067083 @default.
• W3117871953 cites W3047331895 @default.
• W3117871953 cites W3091727001 @default.
• W3117871953 cites W3092551716 @default.
• W3117871953 cites W3117871953 @default.
• W3117871953 cites W4252668826 @default.
• W3117871953 cites W55026472 @default.
• W3117871953 doi "https://doi.org/10.1111/jcmm.16182" @default.
• W3117871953 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7812303" @default.
• W3117871953 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33336505" @default.
• W3117871953 hasPublicationYear "2020" @default.
• W3117871953 type Work @default.
• W3117871953 sameAs 3117871953 @default.
• W3117871953 citedByCount "5" @default.
• W3117871953 countsByYear W31178719532020 @default.
• W3117871953 countsByYear W31178719532021 @default.
• W3117871953 countsByYear W31178719532022 @default.
• W3117871953 countsByYear W31178719532023 @default.
• W3117871953 crossrefType "journal-article" @default.
• W3117871953 hasAuthorship W3117871953A5000409712 @default.
• W3117871953 hasAuthorship W3117871953A5001549014 @default.
• W3117871953 hasAuthorship W3117871953A5015174193 @default.
• W3117871953 hasAuthorship W3117871953A5048279362 @default.
• W3117871953 hasAuthorship W3117871953A5062448359 @default.
• W3117871953 hasAuthorship W3117871953A5065101788 @default.
• W3117871953 hasAuthorship W3117871953A5077873585 @default.
• W3117871953 hasBestOaLocation W31178719531 @default.
• W3117871953 hasConcept C111566952 @default.
• W3117871953 hasConcept C126322002 @default.
• W3117871953 hasConcept C134018914 @default.
• W3117871953 hasConcept C164705383 @default.
• W3117871953 hasConcept C167414201 @default.
• W3117871953 hasConcept C174940676 @default.
• W3117871953 hasConcept C2777420927 @default.
• W3117871953 hasConcept C2778198053 @default.
• W3117871953 hasConcept C2778271984 @default.
• W3117871953 hasConcept C2780559512 @default.
• W3117871953 hasConcept C3018791406 @default.
• W3117871953 hasConcept C71924100 @default.
• W3117871953 hasConceptScore W3117871953C111566952 @default.
• W3117871953 hasConceptScore W3117871953C126322002 @default.
• W3117871953 hasConceptScore W3117871953C134018914 @default.

• next