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• W3117909968 abstract "Two interleukin (IL)-17 N genes ( CcIL-17Na and b ) present on different linkage groups were identified in the common carp ( Cyprinus carpio ) genome and confirmed by polymerase chain reaction (PCR) and real time (RT)-PCR in this experiment. Synteny analysis revealed that IL-17 N is transcribed by the complement sequence of TOP3B's intron 2. It is flanked by SDF2L and PPM1F in all fish studied to date, except fugu ( Takifugu rubripes ). The open reading frames of the two CcIL-17Ns are 411 base pairs long and encode 136 amino acids. The amino acid identity/similarity between CcIL-17Na and b is 91.2%/97.1%. The CcIL-17Ns share identity (46.8–90.4%) with their orthologs from other teleosts. Identities/similarities to other members of the IL-17 family in common carp were low at 21.4–30.2%/31.4–51.4%. In the phylogenetic tree, IL-17Ns from spotted gar ( Lepisosteus oculatus , the ancestor of teleosts) and coelacanth ( Latimeria chalumnae , the ancestor of tetrapods) were grouped within the same branch with a high bootstrap value of 97%, which indicates that IL-17 N is an ancient and conserved gene. Quantitative RT-PCR results showed that CcIL- 17Ns were most highly expressed in the brain of healthy individuals. The expression in brain was significantly induced at 6 h post Aeromonas hydrophila infection; at 1 day post infection, expression in liver, muscle, skin, spleen, and head kidney was up-regulated. In addition, the upregulated expression of proinflammatory cytokines IL-1β, IFN-γ, IL-6, chemokine CCL20, NF - κ B and TRAF6 in kidney tissue by ccIL-17 N recombinant protein also indicate that IL-17 N can promote inflammation through NF-κB pathway and induce the expression of chemokines and inflammatory factors. • Two IL-17 N genes were retrieved and cloned from Cyprinus carpio. • Evolution analyses of fish IL-17Ns were performed. • Gene expression patterns of CcIL-17Ns were determined. • Recombinant CcIL-17Ns protein was proved to be involved in the proinflammatory process." @default.
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• W3117909968 date "2021-04-01" @default.
• W3117909968 modified "2023-10-14" @default.
• W3117909968 title "Identification, expression and pro-inflammatory effect of interleukin-17 N in common carp (Cyprinus carpio L.)" @default.
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• W3117909968 doi "https://doi.org/10.1016/j.fsi.2020.11.024" @default.
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