FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117936799> ?p ?o ?g. }

• W3117936799 endingPage "14" @default.
• W3117936799 startingPage "5" @default.
• W3117936799 abstract "BACKGROUND: Despite the increasing interest in expanding the use of real-world evidence (RWE) in economic assessments of pharmaceuticals, decision makers face uncertainty about how RWE should be used. OBJECTIVE: To assess the use of RWE in economic assessments of drugs by the Institute for Clinical and Economic Review (ICER). METHODS: We reviewed cost-effectiveness and budget impact analyses in final evidence reports of pharmaceuticals published by ICER. We calculated the total number of RWE uses and the proportion of model inputs informed by RWE per report. We classified model inputs into 15 categories based on their attributes and then examined what category each RWE informed to classify the reason for RWE use. Finally, we characterized RWE by study design, data source, and sponsor type. RESULTS: We identified 33 reports, all of which used RWE; the mean RWE use per report was 12 (range = 4-26). The average proportion of model inputs informed by RWE per report was 32.7%, but this proportion had a wide range (range = 4.1%-76.9%). RWE was most commonly used for disease progression inputs (28.7%) and health care resource utilization and costs (21.1%), but was rarely used for drug-specific clinical outcomes such as effectiveness (1.5%), adverse drug event rates (0.5%), and discontinuation rates (1.2%). The most frequently used study design was a retrospective cohort (56.6%), and the most frequently used data source was registry data (41.4%). About a third (30.2%) of RWE was industry-sponsored. CONCLUSIONS: RWE has been commonly used to inform pharmaceutical value assessments conducted by ICER. However, there has been relatively limited use of RWE to inform drug-specific effectiveness, despite calls for greater inclusion of RWE in value assessments for real-world drug effectiveness. DISCLOSURES: This study was funded by the University of Washington School of Pharmacy Corporate Advisory Board Health Tech Fund (HTF). The funder had no role in management, analysis, and interpretation of the data; preparation, review, and approval of the manuscript; and the decision to submit the manuscript for publication. All authors were employed by the CHOICE Institute, University of Washington School of Pharmacy, at the time of the study. Carlson reports grants from the Institute for Clinical and Economic Review during the conduct of the study and personal fees from Bayer, Adaptive Biotechnologies, Allergan, Galderma, and ViFor Pharma, unrelated to this study. Veenstra reports personal fees from several manufacturers unrelated to this study. The other authors have nothing to disclose." @default.
• W3117936799 created "2021-01-05" @default.
• W3117936799 creator A5008934716 @default.
• W3117936799 creator A5010153281 @default.
• W3117936799 creator A5038960629 @default.
• W3117936799 creator A5068073076 @default.
• W3117936799 creator A5085042140 @default.
• W3117936799 creator A5087041753 @default.
• W3117936799 date "2021-01-01" @default.
• W3117936799 modified "2023-10-16" @default.
• W3117936799 title "Use of real-world evidence in economic assessments of pharmaceuticals in the United States" @default.
• W3117936799 cites W130665911 @default.
• W3117936799 cites W2069296472 @default.
• W3117936799 cites W2157450846 @default.
• W3117936799 cites W2163878956 @default.
• W3117936799 cites W2274463749 @default.
• W3117936799 cites W2415878279 @default.
• W3117936799 cites W2519603001 @default.
• W3117936799 cites W2527393952 @default.
• W3117936799 cites W2542690541 @default.
• W3117936799 cites W2560688864 @default.
• W3117936799 cites W2755504031 @default.
• W3117936799 cites W2767186812 @default.
• W3117936799 cites W2772273401 @default.
• W3117936799 cites W2810184386 @default.
• W3117936799 cites W2899593300 @default.
• W3117936799 cites W2900805813 @default.
• W3117936799 cites W2902231822 @default.
• W3117936799 cites W2904484213 @default.
• W3117936799 cites W3006250702 @default.
• W3117936799 cites W3085659227 @default.
• W3117936799 doi "https://doi.org/10.18553/jmcp.2021.27.1.005" @default.
• W3117936799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33377439" @default.
• W3117936799 hasPublicationYear "2021" @default.
• W3117936799 type Work @default.
• W3117936799 sameAs 3117936799 @default.
• W3117936799 citedByCount "6" @default.
• W3117936799 countsByYear W31179367992020 @default.
• W3117936799 countsByYear W31179367992021 @default.
• W3117936799 countsByYear W31179367992022 @default.
• W3117936799 countsByYear W31179367992023 @default.
• W3117936799 crossrefType "journal-article" @default.
• W3117936799 hasAuthorship W3117936799A5008934716 @default.
• W3117936799 hasAuthorship W3117936799A5010153281 @default.
• W3117936799 hasAuthorship W3117936799A5038960629 @default.
• W3117936799 hasAuthorship W3117936799A5068073076 @default.
• W3117936799 hasAuthorship W3117936799A5085042140 @default.
• W3117936799 hasAuthorship W3117936799A5087041753 @default.
• W3117936799 hasBestOaLocation W31179367991 @default.
• W3117936799 hasConcept C126322002 @default.
• W3117936799 hasConcept C127413603 @default.
• W3117936799 hasConcept C141071460 @default.
• W3117936799 hasConcept C147176958 @default.
• W3117936799 hasConcept C188897 @default.
• W3117936799 hasConcept C197934379 @default.
• W3117936799 hasConcept C2778715236 @default.
• W3117936799 hasConcept C3018095205 @default.
• W3117936799 hasConcept C71924100 @default.
• W3117936799 hasConceptScore W3117936799C126322002 @default.
• W3117936799 hasConceptScore W3117936799C127413603 @default.
• W3117936799 hasConceptScore W3117936799C141071460 @default.
• W3117936799 hasConceptScore W3117936799C147176958 @default.
• W3117936799 hasConceptScore W3117936799C188897 @default.
• W3117936799 hasConceptScore W3117936799C197934379 @default.
• W3117936799 hasConceptScore W3117936799C2778715236 @default.
• W3117936799 hasConceptScore W3117936799C3018095205 @default.
• W3117936799 hasConceptScore W3117936799C71924100 @default.
• W3117936799 hasIssue "1" @default.
• W3117936799 hasLocation W31179367991 @default.
• W3117936799 hasLocation W31179367992 @default.
• W3117936799 hasOpenAccess W3117936799 @default.
• W3117936799 hasPrimaryLocation W31179367991 @default.
• W3117936799 hasRelatedWork W1999318505 @default.
• W3117936799 hasRelatedWork W2063006222 @default.
• W3117936799 hasRelatedWork W2320498337 @default.
• W3117936799 hasRelatedWork W2399404195 @default.
• W3117936799 hasRelatedWork W2466043692 @default.
• W3117936799 hasRelatedWork W2831487285 @default.
• W3117936799 hasRelatedWork W3007321116 @default.
• W3117936799 hasRelatedWork W3114253099 @default.
• W3117936799 hasRelatedWork W4290830807 @default.
• W3117936799 hasRelatedWork W4362546065 @default.
• W3117936799 hasVolume "27" @default.
• W3117936799 isParatext "false" @default.
• W3117936799 isRetracted "false" @default.
• W3117936799 magId "3117936799" @default.
• W3117936799 workType "article" @default.