FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3117942387> ?p ?o ?g. }

• W3117942387 abstract "Objective — to evaluate the validity of serological markers in the diagnosis of non‑alcoholic fatty liver disease (NAFLD).Materials and methods. The investigation involved 122 patients with NAFLD aged 19 to 74, including 57 women (46.7 %) and 65 men (53.3 %). The following investigative methods have been used: anthropometric measurements (height, weight, waist circumference, BMI); ultrasound examination of the liver; laboratory (determination of lipid spectrum, insulin resistance, ALT, AST, fibrinogen, free oxyproline, oxyproline protein‑bound, hyaluronic acid, haptoglobin, apolipoprotein A1, a2‑macroglobulin, fibronectin); morphological (puncture biopsy of the liver with histological examination of biopsies); statistical (descriptive statistics, correlation, linear regression and ROC‑analysis).Results. The direct correlation between the degree of steatosis and level of protein‑bound oxyproline (r = 0.22; p < 0.05), the ratio of oxyproline protein‑bound/oxyproline free (r = 0.27; p < 0.05), the level of triglycerides (r = 0.33; p < 0.05), the level of VLDL (r = 0.29; p < 0.05). The direct correlation of moderate strength has been established between the degree of the activity of inflammatory process and levels of hyaluronic acid, a2‑macroglobulin and fibronectin (r = 0.54, 0.67 and 0.55, respectively; p < 0.05 for all) and a moderate inverse relationship for apo‑lipoprotein A1 (r = – 0.56; p < 0.05), haptoglobin (r = – 0.33; p < 0.05) and albumin (r = – 0.45; p < 0.05). Evaluation of correlations showed a direct relationship between the stage of fibrosis and the level of hyaluronic acid, a2‑macro­globulin and fibronectin (r = 0.72, 0.93 and 0.71 at p < 0.05) and a weak relationship with total bilirubin (r = 0.26; p < 0.05). Moderate feedback (r = – 0.61 and ‑0.35 — 0.32; p < 0.05, respectively) was found between apolipoprotein A1, haptoglobin, albumin and fibrosis stage.Conclusions. In patients with steatohepatitis, high diagnostic value was determined for non‑invasive markers of fibrosis: a2‑macroglobulin, apolipoprotein A1, hyaluronic acid and fibronectin for which the area under the ROC curve for minimal fibrosis was not less than 0.75, but more than moderate 0.9. Patients with liver cirrhosis showed a high level of sensitivity (96.4 — 100.0 %) and specificity (75.0 — 100.0 %) of these markers." @default.
• W3117942387 created "2021-01-05" @default.
• W3117942387 creator A5042114076 @default.
• W3117942387 date "2020-12-05" @default.
• W3117942387 modified "2023-09-25" @default.
• W3117942387 title "Non-alcoholic fatty liver disease: non-invasive markers and their importance in diagnosis" @default.
• W3117942387 cites W1267045743 @default.
• W3117942387 cites W1856151485 @default.
• W3117942387 cites W1882608036 @default.
• W3117942387 cites W2025946383 @default.
• W3117942387 cites W2036839644 @default.
• W3117942387 cites W2046994269 @default.
• W3117942387 cites W2047499703 @default.
• W3117942387 cites W2110243916 @default.
• W3117942387 cites W2114168045 @default.
• W3117942387 cites W2256856541 @default.
• W3117942387 cites W2264072217 @default.
• W3117942387 cites W2515617571 @default.
• W3117942387 cites W2786206923 @default.
• W3117942387 cites W2957608484 @default.
• W3117942387 cites W2964476833 @default.
• W3117942387 cites W2990972300 @default.
• W3117942387 doi "https://doi.org/10.30978/mg-2020-6-64" @default.
• W3117942387 hasPublicationYear "2020" @default.
• W3117942387 type Work @default.
• W3117942387 sameAs 3117942387 @default.
• W3117942387 citedByCount "0" @default.
• W3117942387 crossrefType "journal-article" @default.
• W3117942387 hasAuthorship W3117942387A5042114076 @default.
• W3117942387 hasConcept C126322002 @default.
• W3117942387 hasConcept C134018914 @default.
• W3117942387 hasConcept C142724271 @default.
• W3117942387 hasConcept C206396517 @default.
• W3117942387 hasConcept C2778163477 @default.
• W3117942387 hasConcept C2778772119 @default.
• W3117942387 hasConcept C2779134260 @default.
• W3117942387 hasConcept C62746215 @default.
• W3117942387 hasConcept C71924100 @default.
• W3117942387 hasConcept C90924648 @default.
• W3117942387 hasConceptScore W3117942387C126322002 @default.
• W3117942387 hasConceptScore W3117942387C134018914 @default.
• W3117942387 hasConceptScore W3117942387C142724271 @default.
• W3117942387 hasConceptScore W3117942387C206396517 @default.
• W3117942387 hasConceptScore W3117942387C2778163477 @default.
• W3117942387 hasConceptScore W3117942387C2778772119 @default.
• W3117942387 hasConceptScore W3117942387C2779134260 @default.
• W3117942387 hasConceptScore W3117942387C62746215 @default.
• W3117942387 hasConceptScore W3117942387C71924100 @default.
• W3117942387 hasConceptScore W3117942387C90924648 @default.
• W3117942387 hasLocation W31179423871 @default.
• W3117942387 hasOpenAccess W3117942387 @default.
• W3117942387 hasPrimaryLocation W31179423871 @default.
• W3117942387 hasRelatedWork W1185701 @default.
• W3117942387 hasRelatedWork W11974876 @default.
• W3117942387 hasRelatedWork W12296056 @default.
• W3117942387 hasRelatedWork W13611791 @default.
• W3117942387 hasRelatedWork W19598741 @default.
• W3117942387 hasRelatedWork W2285121 @default.
• W3117942387 hasRelatedWork W4654308 @default.
• W3117942387 hasRelatedWork W6847588 @default.
• W3117942387 hasRelatedWork W9080810 @default.
• W3117942387 hasRelatedWork W20759149 @default.
• W3117942387 isParatext "false" @default.
• W3117942387 isRetracted "false" @default.
• W3117942387 magId "3117942387" @default.
• W3117942387 workType "article" @default.