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- W3118019922 abstract "DCP2 is an RNA-decapping enzyme that controls the stability of human RNAs that encode factors functioning in transcription and the immune response. While >1,800 human DCP2 substrates have been identified, compensatory expression changes secondary to genetic ablation of DCP2 have complicated a complete mapping of its regulome. Cell-permeable, selective chemical inhibitors of DCP2 could provide a powerful tool to study DCP2 specificity. Here, we report phage display selection of CP21, a bicyclic peptide ligand to DCP2. CP21 has high affinity and selectivity for DCP2 and inhibits DCP2 decapping activity toward selected RNA substrates in human cells. CP21 increases formation of P-bodies, liquid condensates enriched in intermediates of RNA decay, in a manner that resembles the deletion or mutation of DCP2. We used CP21 to identify 76 previously unreported DCP2 substrates. This work demonstrates that DCP2 inhibition can complement genetic approaches to study RNA decay." @default.
- W3118019922 created "2021-01-05" @default.
- W3118019922 creator A5002995460 @default.
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- W3118019922 creator A5044171015 @default.
- W3118019922 creator A5045661633 @default.
- W3118019922 creator A5050386940 @default.
- W3118019922 date "2021-04-01" @default.
- W3118019922 modified "2023-09-25" @default.
- W3118019922 title "Discovery of cellular substrates of human RNA-decapping enzyme DCP2 using a stapled bicyclic peptide inhibitor" @default.
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- W3118019922 doi "https://doi.org/10.1016/j.chembiol.2020.12.003" @default.
- W3118019922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8052284" @default.
- W3118019922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33357462" @default.
- W3118019922 hasPublicationYear "2021" @default.
- W3118019922 type Work @default.