Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118041021> ?p ?o ?g. }
Showing items 1 to 54 of
54
with 100 items per page.
- W3118041021 endingPage "121" @default.
- W3118041021 startingPage "120" @default.
- W3118041021 abstract "How necessary, and inevitable, is the pairing between a specific neural circuit and a certain behaviour? Are there consequences for not using the brain regions normatively recruited for a given behaviour?These are some of the most fundamental questions that have important consequences for how we diagnose and treat neuropsychiatric disorders as they affect our understanding of the mapping between pathology and presentation that underscores clinical practice. The new paper by Langley et al 1 provides important answers to these questions through examining the neurocognitive deficits present in a unique cohort of presymptomatic (far from onset) individuals who will eventually develop Huntington’s disease (HD). Specifically, they examine whether the same frontostriatal circuits that support attentional control in healthy adults also support this faculty in pre-HD individuals.The existence of parallel, but interacting, circuits that can be functionally described as cognitive, emotional or motoric within frontostriatal circuits accounts for both the selective and synoptic deficits across these domains in neuropsychiatric conditions like HD.2 Our understanding of frontostriatal circuits has been greatly enriched by the intradimensional/extradimensional (ID/ED) set-shifting task. Developed to disentangle attentional control processes, …" @default.
- W3118041021 created "2021-01-05" @default.
- W3118041021 creator A5026509682 @default.
- W3118041021 date "2020-12-28" @default.
- W3118041021 modified "2023-09-27" @default.
- W3118041021 title "Necessary impairments? The downside of functional compensation in frontostriatal circuits in people with presymptomatic Huntington’s disease" @default.
- W3118041021 cites W1951616283 @default.
- W3118041021 cites W1970059247 @default.
- W3118041021 cites W1981751885 @default.
- W3118041021 cites W1987755799 @default.
- W3118041021 cites W2079450984 @default.
- W3118041021 cites W2135687796 @default.
- W3118041021 cites W2256669593 @default.
- W3118041021 cites W3095250012 @default.
- W3118041021 doi "https://doi.org/10.1136/jnnp-2020-324678" @default.
- W3118041021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33372051" @default.
- W3118041021 hasPublicationYear "2020" @default.
- W3118041021 type Work @default.
- W3118041021 sameAs 3118041021 @default.
- W3118041021 citedByCount "0" @default.
- W3118041021 crossrefType "journal-article" @default.
- W3118041021 hasAuthorship W3118041021A5026509682 @default.
- W3118041021 hasConcept C15744967 @default.
- W3118041021 hasConcept C169760540 @default.
- W3118041021 hasConcept C180747234 @default.
- W3118041021 hasConcept C2780023022 @default.
- W3118041021 hasConcept C77805123 @default.
- W3118041021 hasConceptScore W3118041021C15744967 @default.
- W3118041021 hasConceptScore W3118041021C169760540 @default.
- W3118041021 hasConceptScore W3118041021C180747234 @default.
- W3118041021 hasConceptScore W3118041021C2780023022 @default.
- W3118041021 hasConceptScore W3118041021C77805123 @default.
- W3118041021 hasFunder F4320319990 @default.
- W3118041021 hasIssue "2" @default.
- W3118041021 hasLocation W31180410211 @default.
- W3118041021 hasOpenAccess W3118041021 @default.
- W3118041021 hasPrimaryLocation W31180410211 @default.
- W3118041021 hasRelatedWork W1985950550 @default.
- W3118041021 hasRelatedWork W2042940951 @default.
- W3118041021 hasRelatedWork W2050944115 @default.
- W3118041021 hasRelatedWork W2065074698 @default.
- W3118041021 hasRelatedWork W2085642841 @default.
- W3118041021 hasRelatedWork W2093287941 @default.
- W3118041021 hasRelatedWork W2118417921 @default.
- W3118041021 hasRelatedWork W2128524530 @default.
- W3118041021 hasRelatedWork W2144689546 @default.
- W3118041021 hasRelatedWork W2546720468 @default.
- W3118041021 hasVolume "92" @default.
- W3118041021 isParatext "false" @default.
- W3118041021 isRetracted "false" @default.
- W3118041021 magId "3118041021" @default.
- W3118041021 workType "article" @default.