SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118091331> ?p ?o ?g. }

Showing items 1 to 100 of ±110 with 100 items per page.

W3118091331 endingPage "53" @default.
W3118091331 startingPage "53" @default.
W3118091331 abstract "Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8 enters human cells by a classical clathrin-mediated endocytosis pathway; however, the cell receptor or other cell entry factors that may be relevant for an efficient viral infection are unknown. In this work we used a far-Western blotting approach to identify cellular proteins that interact with the recombinant capsid spike proteins of HAstV serotypes 1, 2, and 8, synthesized in Escherichia coli. We identified the 72 kDa protein disulfide isomerase A4 (PDIA4) as a binding partner for HAstV-1 and -8 spikes, but not for the HAstV-2 spike. In agreement with this observation, the PDI inhibitor 16F16 strongly blocked infection by HAstV serotypes 1 and 8, but not serotype 2. RNA interference of PDIA4 expression selectively blocked HAstV-8 infectivity. We also showed that the PDI activity does not affect virus binding or internalization but is required for uncoating of the viral genome." @default.
W3118091331 created "2021-01-05" @default.
W3118091331 creator A5019649994 @default.
W3118091331 creator A5029668968 @default.
W3118091331 creator A5085169821 @default.
W3118091331 creator A5089461814 @default.
W3118091331 date "2020-12-31" @default.
W3118091331 modified "2023-10-18" @default.
W3118091331 title "Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry" @default.
W3118091331 cites W1579841907 @default.
W3118091331 cites W1773066715 @default.
W3118091331 cites W1980112481 @default.
W3118091331 cites W1997921150 @default.
W3118091331 cites W2033199474 @default.
W3118091331 cites W2044866252 @default.
W3118091331 cites W2049273669 @default.
W3118091331 cites W2052489746 @default.
W3118091331 cites W2052627330 @default.
W3118091331 cites W2054604939 @default.
W3118091331 cites W2060560636 @default.
W3118091331 cites W2065137422 @default.
W3118091331 cites W2068644948 @default.
W3118091331 cites W2076474999 @default.
W3118091331 cites W2096271769 @default.
W3118091331 cites W2102640997 @default.
W3118091331 cites W2107356426 @default.
W3118091331 cites W2108186697 @default.
W3118091331 cites W2110850519 @default.
W3118091331 cites W2194570332 @default.
W3118091331 cites W2319888731 @default.
W3118091331 cites W2548756903 @default.
W3118091331 cites W2575108532 @default.
W3118091331 cites W2591540615 @default.
W3118091331 cites W2766634477 @default.
W3118091331 cites W2793909048 @default.
W3118091331 cites W2805443531 @default.
W3118091331 cites W2896609264 @default.
W3118091331 cites W2909586387 @default.
W3118091331 doi "https://doi.org/10.3390/v13010053" @default.
W3118091331 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7824429" @default.
W3118091331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33396308" @default.
W3118091331 hasPublicationYear "2020" @default.
W3118091331 type Work @default.
W3118091331 sameAs 3118091331 @default.
W3118091331 citedByCount "18" @default.
W3118091331 countsByYear W31180913312021 @default.
W3118091331 countsByYear W31180913312022 @default.
W3118091331 countsByYear W31180913312023 @default.
W3118091331 crossrefType "journal-article" @default.
W3118091331 hasAuthorship W3118091331A5019649994 @default.
W3118091331 hasAuthorship W3118091331A5029668968 @default.
W3118091331 hasAuthorship W3118091331A5085169821 @default.
W3118091331 hasAuthorship W3118091331A5089461814 @default.
W3118091331 hasBestOaLocation W31180913311 @default.
W3118091331 hasConcept C106358424 @default.
W3118091331 hasConcept C139770010 @default.
W3118091331 hasConcept C140704245 @default.
W3118091331 hasConcept C1491633281 @default.
W3118091331 hasConcept C153911025 @default.
W3118091331 hasConcept C159047783 @default.
W3118091331 hasConcept C202878990 @default.
W3118091331 hasConcept C2522874641 @default.
W3118091331 hasConcept C27256138 @default.
W3118091331 hasConcept C28005876 @default.
W3118091331 hasConcept C5098756 @default.
W3118091331 hasConcept C55493867 @default.
W3118091331 hasConcept C58475186 @default.
W3118091331 hasConcept C63162447 @default.
W3118091331 hasConcept C86803240 @default.
W3118091331 hasConceptScore W3118091331C106358424 @default.
W3118091331 hasConceptScore W3118091331C139770010 @default.
W3118091331 hasConceptScore W3118091331C140704245 @default.
W3118091331 hasConceptScore W3118091331C1491633281 @default.
W3118091331 hasConceptScore W3118091331C153911025 @default.
W3118091331 hasConceptScore W3118091331C159047783 @default.
W3118091331 hasConceptScore W3118091331C202878990 @default.
W3118091331 hasConceptScore W3118091331C2522874641 @default.
W3118091331 hasConceptScore W3118091331C27256138 @default.
W3118091331 hasConceptScore W3118091331C28005876 @default.
W3118091331 hasConceptScore W3118091331C5098756 @default.
W3118091331 hasConceptScore W3118091331C55493867 @default.
W3118091331 hasConceptScore W3118091331C58475186 @default.
W3118091331 hasConceptScore W3118091331C63162447 @default.
W3118091331 hasConceptScore W3118091331C86803240 @default.
W3118091331 hasFunder F4320332161 @default.
W3118091331 hasIssue "1" @default.
W3118091331 hasLocation W31180913311 @default.
W3118091331 hasLocation W31180913312 @default.
W3118091331 hasLocation W31180913313 @default.
W3118091331 hasLocation W31180913314 @default.
W3118091331 hasLocation W31180913315 @default.
W3118091331 hasOpenAccess W3118091331 @default.
W3118091331 hasPrimaryLocation W31180913311 @default.
W3118091331 hasRelatedWork W1932710078 @default.
W3118091331 hasRelatedWork W1970932468 @default.
W3118091331 hasRelatedWork W1976788601 @default.
W3118091331 hasRelatedWork W1983916957 @default.
W3118091331 hasRelatedWork W1995328853 @default.