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- W3118142818 abstract "Abstract Objective: We aimed to explore the prognostic value of a disintegrin and metalloproteinase with thrombospondin motifs ( ADAMTS ) genes in gastric cancer (GC). Methods: The RNA-sequencing (RNA-seq) expression data for 351 GC patients and other relevant clinical data was acquired from The Cancer Genome Atlas (TCGA). Survival analysis and a genome-wide gene set enrichment analysis (GSEA) were performed to define the underlying molecular value of the ADAMTS genes in GC development. Results: The Log rank test with both Cox regression and Kaplan–Meier survival analysis showed that ADAMTS 6 expression profile correlated with the GC patients’ clinical outcome. Patients with a high expression of ADAMTS 6 were associated with poor overall survival (OS). Comprehensive survival analysis of the ADAMTS genes suggests that ADAMTS 6 might be an independent predictive factor for the OS in patients with GC. Besides, GSEA demonstrated that ADAMTS 6 might be involved in multiple biological processes and pathways, such as the vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), tumor protein P53, c-Jun N-terminal kinase (JNK), cadherin (CDH1) or tumor necrosis factor (TNF) pathways. Conclusions: In summary, our study demonstrated that ADAMTS 6 gene could be used as a potential molecular marker for GC prognosis." @default.
- W3118142818 created "2021-01-05" @default.
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- W3118142818 date "2020-07-14" @default.
- W3118142818 modified "2023-10-18" @default.
- W3118142818 title "Identified a Disintegrin and Metalloproteinase with Thrombospondin Motifs 6 Serve as a Novel Gastric Cancer Prognostic Biomarker by Integrating Analysis of Gene Expression Profile" @default.
- W3118142818 doi "https://doi.org/10.21203/rs.3.rs-41038/v1" @default.
- W3118142818 hasPublicationYear "2020" @default.
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