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• W3118147180 abstract "Abstract Thermodynamic propensities of biomolecules to adopt non-native conformations are crucial for understanding how they function, but prove difficult to measure experimentally. Combining optical melting experiments with chemical modifications and mutations, we developed delta-Melt for measuring the energetic penalties associated with nucleic acid conformational rearrangements and how they vary with sequence and physiological conditions. delta-Melt is fast, simple, cost effective, and can characterize conformational penalties inaccessible to conventional biophysical methods." @default.
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• W3118147180 date "2021-01-18" @default.
• W3118147180 modified "2023-09-25" @default.
• W3118147180 title "delta-Melt: Nucleic acid conformational penalties from melting experiments" @default.
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• W3118147180 doi "https://doi.org/10.21203/rs.3.rs-136535/v1" @default.
• W3118147180 hasPublicationYear "2021" @default.
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