Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118183485> ?p ?o ?g. }
- W3118183485 abstract "Obesity is an excess accumulation of body fat. Its progression rate has remained high in recent years. Therefore, the aim of this study was to diagnose important differentially expressed genes (DEGs) associated in its development, which may be used as novel biomarkers or potential therapeutic targets for obesity. The gene expression profile of E-MTAB-6728 was downloaded from the database. After screening DEGs in each ArrayExpress dataset, we further used the robust rank aggregation method to diagnose 876 significant DEGs including 438 up regulated and 438 down regulated genes. Functional enrichment analysis was performed. These DEGs were shown to be significantly enriched in different obesity related pathways and GO functions. Then protein-protein interaction network, target genes - miRNA regulatory network and target genes - TF regulatory network were constructed and analyzed. The module analysis was performed based on the whole PPI network. We finally filtered out STAT3, CORO1C, SERPINH1, MVP, ITGB5, PCM1, SIRT1, EEF1G, PTEN and RPS2 hub genes. Hub genes were validated by ICH analysis, receiver operating curve (ROC) analysis and RT-PCR. Finally a molecular docking study was performed to find small drug molecules. The robust DEGs linked with the development of obesity were screened through the expression profile, and integrated bioinformatics analysis was conducted. Our study provides reliable molecular biomarkers for screening and diagnosis, prognosis as well as novel therapeutic targets for obesity." @default.
- W3118183485 created "2021-01-05" @default.
- W3118183485 creator A5007122462 @default.
- W3118183485 creator A5019128157 @default.
- W3118183485 creator A5035997459 @default.
- W3118183485 creator A5059976576 @default.
- W3118183485 creator A5067870794 @default.
- W3118183485 creator A5082283937 @default.
- W3118183485 date "2021-06-24" @default.
- W3118183485 modified "2023-09-25" @default.
- W3118183485 title "Identification of Key Pathways and Genes in Obesity Using Bioinformatics Analysis and Molecular Docking Studies" @default.
- W3118183485 cites W1486445524 @default.
- W3118183485 cites W1496645584 @default.
- W3118183485 cites W1501019277 @default.
- W3118183485 cites W1542751389 @default.
- W3118183485 cites W1542905057 @default.
- W3118183485 cites W1544671208 @default.
- W3118183485 cites W1675830194 @default.
- W3118183485 cites W1761895012 @default.
- W3118183485 cites W1865046109 @default.
- W3118183485 cites W1887649560 @default.
- W3118183485 cites W1916946492 @default.
- W3118183485 cites W1923951368 @default.
- W3118183485 cites W1963833285 @default.
- W3118183485 cites W1966372938 @default.
- W3118183485 cites W1971686349 @default.
- W3118183485 cites W1973508741 @default.
- W3118183485 cites W1973825932 @default.
- W3118183485 cites W1973934213 @default.
- W3118183485 cites W1974314455 @default.
- W3118183485 cites W1975787075 @default.
- W3118183485 cites W1976040781 @default.
- W3118183485 cites W1976285590 @default.
- W3118183485 cites W1977281100 @default.
- W3118183485 cites W1978281808 @default.
- W3118183485 cites W1979132764 @default.
- W3118183485 cites W1979188065 @default.
- W3118183485 cites W1980258977 @default.
- W3118183485 cites W1980533832 @default.
- W3118183485 cites W1980556134 @default.
- W3118183485 cites W1982567520 @default.
- W3118183485 cites W1982576397 @default.
- W3118183485 cites W1984958477 @default.
- W3118183485 cites W1986550373 @default.
- W3118183485 cites W1993143104 @default.
- W3118183485 cites W1998460673 @default.
- W3118183485 cites W2000934244 @default.
- W3118183485 cites W2001311476 @default.
- W3118183485 cites W2002912012 @default.
- W3118183485 cites W2006617902 @default.
- W3118183485 cites W2015598035 @default.
- W3118183485 cites W2017031654 @default.
- W3118183485 cites W2017297735 @default.
- W3118183485 cites W2017314529 @default.
- W3118183485 cites W2020820594 @default.
- W3118183485 cites W2024400555 @default.
- W3118183485 cites W2033167203 @default.
- W3118183485 cites W2034733849 @default.
- W3118183485 cites W2036653587 @default.
- W3118183485 cites W2036938272 @default.
- W3118183485 cites W2040117268 @default.
- W3118183485 cites W2041252409 @default.
- W3118183485 cites W2045042199 @default.
- W3118183485 cites W2045647805 @default.
- W3118183485 cites W2047837955 @default.
- W3118183485 cites W2048288273 @default.
- W3118183485 cites W2048695114 @default.
- W3118183485 cites W2052210065 @default.
- W3118183485 cites W2053456405 @default.
- W3118183485 cites W2053786671 @default.
- W3118183485 cites W2055550557 @default.
- W3118183485 cites W2059921289 @default.
- W3118183485 cites W2061093976 @default.
- W3118183485 cites W2064671985 @default.
- W3118183485 cites W2068804834 @default.
- W3118183485 cites W2070171616 @default.
- W3118183485 cites W2070996050 @default.
- W3118183485 cites W2074774606 @default.
- W3118183485 cites W2075800819 @default.
- W3118183485 cites W2077510077 @default.
- W3118183485 cites W2078378773 @default.
- W3118183485 cites W2078638255 @default.
- W3118183485 cites W2079386482 @default.
- W3118183485 cites W2079943017 @default.
- W3118183485 cites W2085765419 @default.
- W3118183485 cites W2088266150 @default.
- W3118183485 cites W2089890147 @default.
- W3118183485 cites W2091267022 @default.
- W3118183485 cites W2092082564 @default.
- W3118183485 cites W2092123736 @default.
- W3118183485 cites W2092400388 @default.
- W3118183485 cites W2095587967 @default.
- W3118183485 cites W2096209727 @default.
- W3118183485 cites W2098474645 @default.
- W3118183485 cites W2098563995 @default.
- W3118183485 cites W2099180218 @default.
- W3118183485 cites W2099631990 @default.
- W3118183485 cites W2100333367 @default.
- W3118183485 cites W2100344946 @default.
- W3118183485 cites W2101076088 @default.