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• W3118221251 abstract "<b><i>Introduction:</i></b> Severe oesophageal dysmotility is associated with treatment-resistant reflux and pulmonary reflux aspiration. Delayed solid gastric emptying has been associated with oesophageal dysmotility; however, the role of delayed liquid gastric emptying (LGE) in the pathophysiology of severe reflux disease remains unknown. The purpose of this study is to examine the relationship between delayed LGE, reflux aspiration, and oesophageal dysmotility. <b><i>Methods:</i></b> Data were extracted from a prospectively populated database of patients with severe treatment-resistant gastro-oesophageal reflux disease. All patients with validated reflux aspiration scintigraphy and oesophageal manometry were included in the analysis. Patients were classified by predominant clinical subtype as gastro-oesophageal reflux (GOR) or laryngopharyngeal reflux. LGE time of 22 min or longer was considered delayed. <b><i>Results:</i></b> Inclusion criteria were met by 631 patients. Normal LGE time was found in 450 patients, whilst 181 had evidence of delayed LGE. Mean liquid half-clearance was 22.81 min. Reflux aspiration was evident in 240 patients (38%). Difference in the aspiration rates between delayed LGE (42%) and normal LGE (36%) was not significant (<i>p</i> = 0.16). Severe ineffective oesophageal motility (IOM) was found in 70 patients (35%) and was independent of LGE time. Severe IOM was strongly associated with reflux aspiration (<i>p</i> &#x3c; 0.001). GOR dominant symptoms were more common in patients with delayed LGE (<i>p</i> = 0.03). <b><i>Conclusion:</i></b> Severe IOM was strongly associated with reflux aspiration. Delayed LGE is not associated with reflux aspiration or severe IOM. Delayed LGE is more prevalent in patients presenting with GOR dominant symptoms." @default.
• W3118221251 created "2021-01-05" @default.
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• W3118221251 date "2020-12-30" @default.
• W3118221251 modified "2023-09-27" @default.
• W3118221251 title "Reflux Aspiration Associated with Oesophageal Dysmotility but Not Delayed Liquid Gastric Emptying" @default.
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• W3118221251 doi "https://doi.org/10.1159/000514108" @default.
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