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- W3118240122 abstract "World Health Organization (WHO) estimated breast cancer as one of the most prevailed malignancy around the globe. Its incident cases are gradually increasing every year, resulting in considerable healthcare burden. The heterogeneity of breast cancer accounts for its differential molecular subtyping, interaction between pathways, DNA damaging, and chronic inflammation. Matrix metalloproteinases (MMPs) are a group of zinc-containing, calcium dependent endopeptidases which play a substantial role in breast carcinogenesis through several mechanisms. These mechanisms include remodeling of extracellular matrix (ECM), cell proliferation, and angiogenesis which promote metastasis and result in tumor progression. In this context, compounds bearing MMP inhibitory potential can serve as potent therapeutic agents in combating MMPs provoked breast cancer. Current systematic review aimed to encompass the details of potent natural lead molecules that can deter MMPs-provoked breast cancer. Following the critical appraisal of literature, a total of n = 44 studies that explored inhibitory effect of phytochemicals on MMPs were included in this review. These phytoconstituents include alkaloids ( n = 11), flavonoids ( n = 23), terpenoids ( n = 7), and lignans ( n = 2). The most common inhibitory methods used to evaluate efficacy of these phytoconstituents included Gelatin Zymography, Western Blotting, and real time polymerase chain reaction (RT-PCR) analysis. Moreover, current limitations, challenges, and future directions of using such compounds have been critically discussed. This review underscores the potential implications of phytochemicals in the management of breast cancer which could lessen the growing encumbrance of disease." @default.
- W3118240122 created "2021-01-18" @default.
- W3118240122 creator A5019590111 @default.
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- W3118240122 creator A5079916396 @default.
- W3118240122 date "2021-01-15" @default.
- W3118240122 modified "2023-10-10" @default.
- W3118240122 title "Potential Role of Phytochemicals Against Matrix Metalloproteinase Induced Breast Cancer; An Explanatory Review" @default.
- W3118240122 cites W103473708 @default.
- W3118240122 cites W1504568599 @default.
- W3118240122 cites W1605046409 @default.
- W3118240122 cites W1787043696 @default.
- W3118240122 cites W1921220968 @default.
- W3118240122 cites W1963857608 @default.
- W3118240122 cites W1964770292 @default.
- W3118240122 cites W1967830419 @default.
- W3118240122 cites W1976606354 @default.
- W3118240122 cites W1978265206 @default.
- W3118240122 cites W1979163694 @default.
- W3118240122 cites W1982103277 @default.
- W3118240122 cites W1982991375 @default.
- W3118240122 cites W1987562992 @default.
- W3118240122 cites W1992548225 @default.
- W3118240122 cites W1993046616 @default.
- W3118240122 cites W1995619609 @default.
- W3118240122 cites W2002449811 @default.
- W3118240122 cites W2002771508 @default.
- W3118240122 cites W2008544938 @default.
- W3118240122 cites W2008936830 @default.
- W3118240122 cites W2009098686 @default.
- W3118240122 cites W2015920267 @default.
- W3118240122 cites W2016741474 @default.
- W3118240122 cites W2019524085 @default.
- W3118240122 cites W2022666838 @default.
- W3118240122 cites W2023553617 @default.
- W3118240122 cites W2029830994 @default.
- W3118240122 cites W2043455700 @default.
- W3118240122 cites W2043992157 @default.
- W3118240122 cites W2049659018 @default.
- W3118240122 cites W2051019673 @default.
- W3118240122 cites W2051031118 @default.
- W3118240122 cites W2053530740 @default.
- W3118240122 cites W2057088218 @default.
- W3118240122 cites W2059717332 @default.
- W3118240122 cites W2060783095 @default.
- W3118240122 cites W2067330776 @default.
- W3118240122 cites W2069756877 @default.
- W3118240122 cites W2070601224 @default.
- W3118240122 cites W2071359561 @default.
- W3118240122 cites W2075339470 @default.
- W3118240122 cites W2086490297 @default.
- W3118240122 cites W2092205020 @default.
- W3118240122 cites W2095017005 @default.
- W3118240122 cites W2099914563 @default.
- W3118240122 cites W2104288188 @default.
- W3118240122 cites W2105546015 @default.
- W3118240122 cites W2110946623 @default.
- W3118240122 cites W2124309131 @default.
- W3118240122 cites W2124777183 @default.
- W3118240122 cites W2125899548 @default.
- W3118240122 cites W2125974556 @default.
- W3118240122 cites W2127289044 @default.
- W3118240122 cites W2132316821 @default.
- W3118240122 cites W2133312268 @default.
- W3118240122 cites W2136532468 @default.
- W3118240122 cites W2137601582 @default.
- W3118240122 cites W2139965055 @default.
- W3118240122 cites W2141366098 @default.
- W3118240122 cites W2141803725 @default.
- W3118240122 cites W2142289197 @default.
- W3118240122 cites W2143150598 @default.
- W3118240122 cites W2144868623 @default.
- W3118240122 cites W2146589814 @default.
- W3118240122 cites W2153473625 @default.
- W3118240122 cites W2155642175 @default.
- W3118240122 cites W2157833022 @default.
- W3118240122 cites W2158899005 @default.
- W3118240122 cites W2167011180 @default.
- W3118240122 cites W2168430833 @default.
- W3118240122 cites W2186588483 @default.
- W3118240122 cites W2276751188 @default.
- W3118240122 cites W2335041534 @default.
- W3118240122 cites W2516251129 @default.
- W3118240122 cites W2555935710 @default.
- W3118240122 cites W2612105766 @default.
- W3118240122 cites W2735145309 @default.
- W3118240122 cites W2781478615 @default.
- W3118240122 cites W2793819701 @default.
- W3118240122 cites W2796031670 @default.
- W3118240122 cites W2888700197 @default.
- W3118240122 cites W2891450166 @default.
- W3118240122 cites W2898121281 @default.