FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118251504> ?p ?o ?g. }

• W3118251504 abstract "Cellular phenotypes on bioactive compound treatment are a result of the downstream targets of the respective treatment. Here, a computational approach is taken for downstream subcellular target identification to understand the basis of the cellular response. This response is a readout of cellular phenotypes captured from cell-painting-based light microscopy images. The readouts are morphological profiles measured simultaneously from multiple cellular organelles. Cellular profiles generated from roughly 270 diverse treatments on bone cancer cell line form the high content screen used in this study. Phenotypic diversity across these treatments is demonstrated, depending on the image-based phenotypic profiles. Furthermore, the impact of the treatments on specific organelles and associated organelle sensitivities are determined. This revealed that endoplasmic reticulum has a higher likelihood of being targeted. Employing multivariate regression overall cellular response is predicted based on fewer organelle responses. This prediction model is validated against 1,000 new candidate compounds. Different compounds despite driving specific modulation outcomes elicit a varying effect on cellular integrity. Strikingly, this confirms that phenotypic responses are not conserved that enables quantification of signaling heterogeneity. Agonist-antagonist signaling pairs demonstrate switch of the targets in the cascades hinting toward evidence of signaling plasticity. Quantitative analysis of the screen has enabled the identification of these underlying signatures. Together, these image-based profiling approaches can be employed for target identification in drug and diseased states and understand the hallmark of cellular response." @default.
• W3118251504 created "2021-01-18" @default.
• W3118251504 creator A5040327437 @default.
• W3118251504 date "2021-01-07" @default.
• W3118251504 modified "2023-10-05" @default.
• W3118251504 title "High Content Analysis Across Signaling Modulation Treatments for Subcellular Target Identification Reveals Heterogeneity in Cellular Response" @default.
• W3118251504 cites W1967660686 @default.
• W3118251504 cites W1972748508 @default.
• W3118251504 cites W1985317603 @default.
• W3118251504 cites W1998202992 @default.
• W3118251504 cites W2019062120 @default.
• W3118251504 cites W2019222884 @default.
• W3118251504 cites W2025058895 @default.
• W3118251504 cites W2031441006 @default.
• W3118251504 cites W2031904808 @default.
• W3118251504 cites W2039468377 @default.
• W3118251504 cites W2050551672 @default.
• W3118251504 cites W2062518664 @default.
• W3118251504 cites W2068324025 @default.
• W3118251504 cites W2075258506 @default.
• W3118251504 cites W2079745490 @default.
• W3118251504 cites W2086244613 @default.
• W3118251504 cites W2092710950 @default.
• W3118251504 cites W2093535002 @default.
• W3118251504 cites W2104036010 @default.
• W3118251504 cites W2107554012 @default.
• W3118251504 cites W2108215899 @default.
• W3118251504 cites W2108303909 @default.
• W3118251504 cites W2121604817 @default.
• W3118251504 cites W2123059506 @default.
• W3118251504 cites W2128930132 @default.
• W3118251504 cites W2143784594 @default.
• W3118251504 cites W2144963196 @default.
• W3118251504 cites W2146264532 @default.
• W3118251504 cites W2146768696 @default.
• W3118251504 cites W2147443169 @default.
• W3118251504 cites W2160676466 @default.
• W3118251504 cites W2164351958 @default.
• W3118251504 cites W2165064047 @default.
• W3118251504 cites W2211797036 @default.
• W3118251504 cites W2259538443 @default.
• W3118251504 cites W2317877264 @default.
• W3118251504 cites W2325307364 @default.
• W3118251504 cites W2509141893 @default.
• W3118251504 cites W2529501230 @default.
• W3118251504 cites W2596519089 @default.
• W3118251504 cites W2604527271 @default.
• W3118251504 cites W2617667835 @default.
• W3118251504 cites W2627654851 @default.
• W3118251504 cites W2729684734 @default.
• W3118251504 cites W2756305734 @default.
• W3118251504 cites W2773577558 @default.
• W3118251504 cites W2794301983 @default.
• W3118251504 cites W2891161893 @default.
• W3118251504 cites W2902890147 @default.
• W3118251504 cites W2912933248 @default.
• W3118251504 cites W2963199063 @default.
• W3118251504 cites W2975712044 @default.
• W3118251504 cites W2989611985 @default.
• W3118251504 cites W2998120965 @default.
• W3118251504 cites W3026468683 @default.
• W3118251504 cites W3041950906 @default.
• W3118251504 cites W4255124627 @default.
• W3118251504 cites W2002798026 @default.
• W3118251504 doi "https://doi.org/10.3389/fcell.2020.594750" @default.
• W3118251504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7817946" @default.
• W3118251504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33490062" @default.
• W3118251504 hasPublicationYear "2021" @default.
• W3118251504 type Work @default.
• W3118251504 sameAs 3118251504 @default.
• W3118251504 citedByCount "1" @default.
• W3118251504 countsByYear W31182515042023 @default.
• W3118251504 crossrefType "journal-article" @default.
• W3118251504 hasAuthorship W3118251504A5040327437 @default.
• W3118251504 hasBestOaLocation W31182515041 @default.
• W3118251504 hasConcept C104317684 @default.
• W3118251504 hasConcept C127716648 @default.
• W3118251504 hasConcept C1491633281 @default.
• W3118251504 hasConcept C150555746 @default.
• W3118251504 hasConcept C157044486 @default.
• W3118251504 hasConcept C158617107 @default.
• W3118251504 hasConcept C168240541 @default.
• W3118251504 hasConcept C190062978 @default.
• W3118251504 hasConcept C2776879804 @default.
• W3118251504 hasConcept C54355233 @default.
• W3118251504 hasConcept C62478195 @default.
• W3118251504 hasConcept C70721500 @default.
• W3118251504 hasConcept C86803240 @default.
• W3118251504 hasConcept C95444343 @default.
• W3118251504 hasConceptScore W3118251504C104317684 @default.
• W3118251504 hasConceptScore W3118251504C127716648 @default.
• W3118251504 hasConceptScore W3118251504C1491633281 @default.
• W3118251504 hasConceptScore W3118251504C150555746 @default.
• W3118251504 hasConceptScore W3118251504C157044486 @default.
• W3118251504 hasConceptScore W3118251504C158617107 @default.
• W3118251504 hasConceptScore W3118251504C168240541 @default.
• W3118251504 hasConceptScore W3118251504C190062978 @default.
• W3118251504 hasConceptScore W3118251504C2776879804 @default.
• W3118251504 hasConceptScore W3118251504C54355233 @default.
• W3118251504 hasConceptScore W3118251504C62478195 @default.

• next