Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118255879> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3118255879 abstract "Retinal degeneration is one of the leading causes of blindness in the developed world. There is currently no effective therapy. In order to improve our understanding of these conditions, we characterised three animal models of retinal degeneration, namely pigmented retinal degeneration slow (rds) mouse, retinal dystrophy (Rdy) cats and the miniature longhaired dachshund dog (MLHD). We then carried out a series of treatment trials using both inhibitors of caspases and neurotrophic factors in these animals. Using immunohistochemical techniques, there was mis-localisation of opsin, reduction of synaptophysin in the outer plexiform layer and increased expression of glial fibrillary acidic protein in Muller cells in all of these animal models. Apoptosis was found to be the main mode of photoreceptor cell death. Photoreceptors in the pigmented rds mouse were found to degenerate more slowly than the albino rds mouse. The Rdy cats had opsin labelled neurites similar to those described in human retinal degeneration. The MLHD dog was demonstrated to have a cone-rod dystrophy (CORD) based on electrophysiological studies. It represents the first animal model of CORD. As apoptosis is the main mode of cell death, we attempted to either block the apoptotic pathway by caspases inhibitors or prevent photoreceptors entering the apoptotic pathway using neurotrophic factors. It appears that DEVD, a caspase-3 inhibitor, might slow photoreceptor cell loss in the pigmented rds mice, but z-VAD and YVAD did not. We have also found that Axokine, a ciliary neurotrophic factor analogue, might prolong photoreceptor cell survival in the Rdy cats, but brain derived neurotrophic factor had no effect. Furthermore, Axokine appears to preserve retinal function in the MLHD dogs as measured by electroretinography for a short period of time after an initial suppression." @default.
- W3118255879 created "2021-01-18" @default.
- W3118255879 creator A5039988192 @default.
- W3118255879 date "2002-01-01" @default.
- W3118255879 modified "2023-09-28" @default.
- W3118255879 title "Retinal degeneration : models and therapies" @default.
- W3118255879 hasPublicationYear "2002" @default.
- W3118255879 type Work @default.
- W3118255879 sameAs 3118255879 @default.
- W3118255879 citedByCount "0" @default.
- W3118255879 crossrefType "dissertation" @default.
- W3118255879 hasAuthorship W3118255879A5039988192 @default.
- W3118255879 hasConcept C160539049 @default.
- W3118255879 hasConcept C169760540 @default.
- W3118255879 hasConcept C170493617 @default.
- W3118255879 hasConcept C190283241 @default.
- W3118255879 hasConcept C202033177 @default.
- W3118255879 hasConcept C203014093 @default.
- W3118255879 hasConcept C204232928 @default.
- W3118255879 hasConcept C2777017193 @default.
- W3118255879 hasConcept C2777093970 @default.
- W3118255879 hasConcept C2780495277 @default.
- W3118255879 hasConcept C2780827179 @default.
- W3118255879 hasConcept C2780916184 @default.
- W3118255879 hasConcept C2781040256 @default.
- W3118255879 hasConcept C30028475 @default.
- W3118255879 hasConcept C31573885 @default.
- W3118255879 hasConcept C54355233 @default.
- W3118255879 hasConcept C55493867 @default.
- W3118255879 hasConcept C68710172 @default.
- W3118255879 hasConcept C86803240 @default.
- W3118255879 hasConcept C95444343 @default.
- W3118255879 hasConceptScore W3118255879C160539049 @default.
- W3118255879 hasConceptScore W3118255879C169760540 @default.
- W3118255879 hasConceptScore W3118255879C170493617 @default.
- W3118255879 hasConceptScore W3118255879C190283241 @default.
- W3118255879 hasConceptScore W3118255879C202033177 @default.
- W3118255879 hasConceptScore W3118255879C203014093 @default.
- W3118255879 hasConceptScore W3118255879C204232928 @default.
- W3118255879 hasConceptScore W3118255879C2777017193 @default.
- W3118255879 hasConceptScore W3118255879C2777093970 @default.
- W3118255879 hasConceptScore W3118255879C2780495277 @default.
- W3118255879 hasConceptScore W3118255879C2780827179 @default.
- W3118255879 hasConceptScore W3118255879C2780916184 @default.
- W3118255879 hasConceptScore W3118255879C2781040256 @default.
- W3118255879 hasConceptScore W3118255879C30028475 @default.
- W3118255879 hasConceptScore W3118255879C31573885 @default.
- W3118255879 hasConceptScore W3118255879C54355233 @default.
- W3118255879 hasConceptScore W3118255879C55493867 @default.
- W3118255879 hasConceptScore W3118255879C68710172 @default.
- W3118255879 hasConceptScore W3118255879C86803240 @default.
- W3118255879 hasConceptScore W3118255879C95444343 @default.
- W3118255879 hasLocation W31182558791 @default.
- W3118255879 hasOpenAccess W3118255879 @default.
- W3118255879 hasPrimaryLocation W31182558791 @default.
- W3118255879 hasRelatedWork W1482556877 @default.
- W3118255879 hasRelatedWork W1556662751 @default.
- W3118255879 hasRelatedWork W1721144965 @default.
- W3118255879 hasRelatedWork W1780664938 @default.
- W3118255879 hasRelatedWork W1790201143 @default.
- W3118255879 hasRelatedWork W1803958254 @default.
- W3118255879 hasRelatedWork W191631729 @default.
- W3118255879 hasRelatedWork W1965255207 @default.
- W3118255879 hasRelatedWork W1981857902 @default.
- W3118255879 hasRelatedWork W2009165363 @default.
- W3118255879 hasRelatedWork W2010029742 @default.
- W3118255879 hasRelatedWork W2023332819 @default.
- W3118255879 hasRelatedWork W2048811478 @default.
- W3118255879 hasRelatedWork W2053711632 @default.
- W3118255879 hasRelatedWork W2084646891 @default.
- W3118255879 hasRelatedWork W2101007937 @default.
- W3118255879 hasRelatedWork W2136749835 @default.
- W3118255879 hasRelatedWork W2145024523 @default.
- W3118255879 hasRelatedWork W420823812 @default.
- W3118255879 hasRelatedWork W958103 @default.
- W3118255879 isParatext "false" @default.
- W3118255879 isRetracted "false" @default.
- W3118255879 magId "3118255879" @default.
- W3118255879 workType "dissertation" @default.