FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118273742> ?p ?o ?g. }

• W3118273742 endingPage "H1088" @default.
• W3118273742 startingPage "H1080" @default.
• W3118273742 abstract "Insufficient sleep is associated with endothelial vasomotor dysfunction and increased cardiovascular risk. Regular aerobic exercise is an effective lifestyle strategy for improving endothelial function and, in turn, reducing cardiovascular risk. We tested the hypotheses that regular aerobic exercise would 1) improve endothelial vasodilation and 2) decrease endothelin (ET)-1-mediated vasoconstrictor tone in middle-aged adults who chronically sleep <7 h/night. Thirty-six healthy, middle-aged adults were studied: 16 with normal sleep duration (age: 57 ± 2 yr; sleep duration: 7.4 ± 0.1 h/night) and 20 with short sleep duration (age: 56 ± 1 yr; sleep duration: 6.2 ± 0.1 h/night). The 20 short sleepers completed a 3-mo aerobic exercise training intervention. Forearm blood flow was determined (via plethysmography) in response to intra-arterial acetylcholine (ACh), BQ-123 (ETA receptor antagonist), ACh + BQ-123, and sodium nitroprusside. Forearm blood flow responses to ACh were lower (∼20%; P < 0.05) in the short (from 4.2 ± 0.2 to 10.5 ± 0.6 mL/100 mL tissue/min) versus normal (4.2 ± 0.2 to 12.7 ± 0.6 mL/100 mL tissue/min) sleepers. In response to BQ-123, the short-sleep group had a significantly greater increase in resting forearm blood flow than the normal-sleep group (∼25% vs. ∼8%). ACh + BQ-123 resulted in a significant (∼25%) increase in the ACh-mediated vasodilation in the short-sleep group only. After exercise training, although nightly sleep duration was unchanged (6.4 ± 0.1 h/night), ACh-mediated vasodilation was significantly higher (∼20%), ET-1-mediated vasoconstriction was significantly lower (∼80%), and the vasodilator response to ACh was not increased with ETA receptor blockade. Regular aerobic exercise, independent of changes in nightly sleep duration, can counteract insufficient sleep-related endothelial vasomotor dysfunction.NEW & NOTEWORTHY Habitual insufficient nightly sleep (<7 h/night) is associated with increased risk of cardiovascular disease and events. Endothelial dysfunction, specifically reduced endothelium-dependent vasodilation and increased endothelin (ET)-1-mediated vasoconstriction, is considered to be a major contributing mechanism underlying increased vascular risk with insufficient sleep. In contrast to insufficient sleep, regular aerobic exercise enhances endothelial vasomotor function, reducing the risk of cardiovascular disease and associated events. In the present study, we determined the effects of aerobic exercise training on endothelium-dependent vasodilation and ET-1 vasoconstriction in adults who habitually sleep <7 h/night. After exercise training, although nightly sleep duration was unchanged, endothelium-dependent vasodilation was significantly enhanced and ET-1-mediated vasoconstrictor tone was significantly reduced in adults who sleep <7 h/night. Regular aerobic exercise training can mitigate insufficient sleep-related endothelial vasomotor dysfunction and, in turn, potentially reduce the cardiovascular risk associated with habitual insufficient nightly sleep." @default.
• W3118273742 created "2021-01-18" @default.
• W3118273742 creator A5000565202 @default.
• W3118273742 creator A5041552869 @default.
• W3118273742 creator A5046514329 @default.
• W3118273742 creator A5082877838 @default.
• W3118273742 creator A5083554092 @default.
• W3118273742 creator A5083744109 @default.
• W3118273742 creator A5088130258 @default.
• W3118273742 date "2021-03-01" @default.
• W3118273742 modified "2023-09-24" @default.
• W3118273742 title "Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep" @default.
• W3118273742 cites W124262366 @default.
• W3118273742 cites W1541415988 @default.
• W3118273742 cites W1824808911 @default.
• W3118273742 cites W1830409642 @default.
• W3118273742 cites W1948854550 @default.
• W3118273742 cites W1966606416 @default.
• W3118273742 cites W1969518250 @default.
• W3118273742 cites W1977011452 @default.
• W3118273742 cites W1987176556 @default.
• W3118273742 cites W1990662781 @default.
• W3118273742 cites W1996391039 @default.
• W3118273742 cites W1998540497 @default.
• W3118273742 cites W2003279143 @default.
• W3118273742 cites W2003728964 @default.
• W3118273742 cites W2011356460 @default.
• W3118273742 cites W2016258977 @default.
• W3118273742 cites W2017236551 @default.
• W3118273742 cites W2017652955 @default.
• W3118273742 cites W2028026454 @default.
• W3118273742 cites W2034447161 @default.
• W3118273742 cites W2035143857 @default.
• W3118273742 cites W2040094385 @default.
• W3118273742 cites W2050663836 @default.
• W3118273742 cites W2057116025 @default.
• W3118273742 cites W2062890459 @default.
• W3118273742 cites W2065566393 @default.
• W3118273742 cites W2082307168 @default.
• W3118273742 cites W2082742992 @default.
• W3118273742 cites W2087726866 @default.
• W3118273742 cites W2088855630 @default.
• W3118273742 cites W2094048358 @default.
• W3118273742 cites W2096348135 @default.
• W3118273742 cites W2098990166 @default.
• W3118273742 cites W2109301401 @default.
• W3118273742 cites W2113842550 @default.
• W3118273742 cites W2119445914 @default.
• W3118273742 cites W2121615964 @default.
• W3118273742 cites W2122931217 @default.
• W3118273742 cites W2130357926 @default.
• W3118273742 cites W2131703274 @default.
• W3118273742 cites W2135405891 @default.
• W3118273742 cites W2139749578 @default.
• W3118273742 cites W2145200932 @default.
• W3118273742 cites W2148663698 @default.
• W3118273742 cites W2150348010 @default.
• W3118273742 cites W2157422098 @default.
• W3118273742 cites W2171647161 @default.
• W3118273742 cites W2213513919 @default.
• W3118273742 cites W2435561583 @default.
• W3118273742 cites W2497443202 @default.
• W3118273742 cites W2685831093 @default.
• W3118273742 cites W2750376662 @default.
• W3118273742 cites W2895566500 @default.
• W3118273742 cites W2942377777 @default.
• W3118273742 cites W2944919276 @default.
• W3118273742 cites W3018333445 @default.
• W3118273742 cites W4232657130 @default.
• W3118273742 cites W4291113428 @default.
• W3118273742 cites W50727066 @default.
• W3118273742 doi "https://doi.org/10.1152/ajpheart.00615.2020" @default.
• W3118273742 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7988760" @default.
• W3118273742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33416458" @default.
• W3118273742 hasPublicationYear "2021" @default.
• W3118273742 type Work @default.
• W3118273742 sameAs 3118273742 @default.
• W3118273742 citedByCount "13" @default.
• W3118273742 countsByYear W31182737422021 @default.
• W3118273742 countsByYear W31182737422022 @default.
• W3118273742 countsByYear W31182737422023 @default.
• W3118273742 crossrefType "journal-article" @default.
• W3118273742 hasAuthorship W3118273742A5000565202 @default.
• W3118273742 hasAuthorship W3118273742A5041552869 @default.
• W3118273742 hasAuthorship W3118273742A5046514329 @default.
• W3118273742 hasAuthorship W3118273742A5082877838 @default.
• W3118273742 hasAuthorship W3118273742A5083554092 @default.
• W3118273742 hasAuthorship W3118273742A5083744109 @default.
• W3118273742 hasAuthorship W3118273742A5088130258 @default.
• W3118273742 hasBestOaLocation W31182737422 @default.
• W3118273742 hasConcept C103038586 @default.
• W3118273742 hasConcept C120770815 @default.
• W3118273742 hasConcept C126322002 @default.
• W3118273742 hasConcept C134018914 @default.
• W3118273742 hasConcept C141071460 @default.
• W3118273742 hasConcept C164705383 @default.
• W3118273742 hasConcept C2776214587 @default.
• W3118273742 hasConcept C2777604165 @default.

• next