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- W3118275854 abstract "Frontotemporal dementia (FTD) is regarded as the second most common form of young-onset dementia after Alzheimer’s disease (AD). FTD is a complex neurodegenerative condition characterised by heterogeneous clinical, pathological and genetic features. No efficient measures for early diagnosis and therapy are available. Familial (Mendelian) forms of disease have been studied over the past 20 years. Conversely, the genetics of sporadic forms of FTD (up to 70% of all cases) is understudied and still poorly understood. All this taken together suggests that more powerful and in-depth studies to tackle missing heritability and define the genetic architecture of sporadic FTD, with particular focus on the different subtypes (i.e. clinical and pathological diagnoses), are warranted. In parallel, it will be critical to translate the genetic findings into functional understanding of disease, i.e. moving from the identification of risk genes to the definition of risk pathways. It will be necessary to implement a paradigm shift – from reductionist to holistic approaches – to better interpret genetics and assist functional studies aimed at modelling and validating such risk pathways. In this chapter, we focus on the heterogeneous features of FTD touching upon its complex genetic landscape and discuss how novel approaches (e.g. computationally driven systems biology) promise to revolutionise the translation of genetic information into functional understanding of disease pathogenesis." @default.
- W3118275854 created "2021-01-18" @default.
- W3118275854 creator A5005572028 @default.
- W3118275854 creator A5011192228 @default.
- W3118275854 date "2021-01-01" @default.
- W3118275854 modified "2023-09-26" @default.
- W3118275854 title "Mendelian and Sporadic FTD: Disease Risk and Avenues from Genetics to Disease Pathways Through In Silico Modelling" @default.
- W3118275854 cites W1511517753 @default.
- W3118275854 cites W1535972936 @default.
- W3118275854 cites W1763842383 @default.
- W3118275854 cites W1764460837 @default.
- W3118275854 cites W1828468335 @default.
- W3118275854 cites W1865452494 @default.
- W3118275854 cites W1867803325 @default.
- W3118275854 cites W1966327575 @default.
- W3118275854 cites W1966479966 @default.
- W3118275854 cites W1974504862 @default.
- W3118275854 cites W1974583546 @default.
- W3118275854 cites W1974760231 @default.
- W3118275854 cites W1980709389 @default.
- W3118275854 cites W1980991473 @default.
- W3118275854 cites W1983316238 @default.
- W3118275854 cites W1985677681 @default.
- W3118275854 cites W1995083646 @default.
- W3118275854 cites W2003283154 @default.
- W3118275854 cites W2024201855 @default.
- W3118275854 cites W2032273411 @default.
- W3118275854 cites W2034183549 @default.
- W3118275854 cites W2035368043 @default.
- W3118275854 cites W2040639372 @default.
- W3118275854 cites W2043345690 @default.
- W3118275854 cites W2056607803 @default.
- W3118275854 cites W2057034125 @default.
- W3118275854 cites W2059772902 @default.
- W3118275854 cites W2060089975 @default.
- W3118275854 cites W2064494086 @default.
- W3118275854 cites W2066308093 @default.
- W3118275854 cites W2073704038 @default.
- W3118275854 cites W2079672765 @default.
- W3118275854 cites W2082313952 @default.
- W3118275854 cites W2082536587 @default.
- W3118275854 cites W2086406144 @default.
- W3118275854 cites W2095403534 @default.
- W3118275854 cites W2100623206 @default.
- W3118275854 cites W2101023175 @default.
- W3118275854 cites W2120039727 @default.
- W3118275854 cites W2125784083 @default.
- W3118275854 cites W2126313782 @default.
- W3118275854 cites W2128030851 @default.
- W3118275854 cites W2137076271 @default.
- W3118275854 cites W2138190873 @default.
- W3118275854 cites W2138207816 @default.
- W3118275854 cites W2141365662 @default.
- W3118275854 cites W2142232658 @default.
- W3118275854 cites W2147958782 @default.
- W3118275854 cites W2150550276 @default.
- W3118275854 cites W2152748843 @default.
- W3118275854 cites W2154945114 @default.
- W3118275854 cites W2156054547 @default.
- W3118275854 cites W2159280728 @default.
- W3118275854 cites W2163955717 @default.
- W3118275854 cites W2171391157 @default.
- W3118275854 cites W2172007938 @default.
- W3118275854 cites W2196275365 @default.
- W3118275854 cites W2210071362 @default.
- W3118275854 cites W2253073911 @default.
- W3118275854 cites W2276090540 @default.
- W3118275854 cites W2310226166 @default.
- W3118275854 cites W2329336071 @default.
- W3118275854 cites W2340895726 @default.
- W3118275854 cites W2345948651 @default.
- W3118275854 cites W2346195607 @default.
- W3118275854 cites W239648239 @default.
- W3118275854 cites W2429544251 @default.
- W3118275854 cites W2525330944 @default.
- W3118275854 cites W2550535012 @default.
- W3118275854 cites W2562565311 @default.
- W3118275854 cites W2565890851 @default.
- W3118275854 cites W2611138580 @default.
- W3118275854 cites W2626375476 @default.
- W3118275854 cites W2737853846 @default.
- W3118275854 cites W2748311674 @default.
- W3118275854 cites W2773991902 @default.
- W3118275854 cites W2783108014 @default.
- W3118275854 cites W2792263831 @default.
- W3118275854 cites W2792537620 @default.
- W3118275854 cites W2792874817 @default.
- W3118275854 cites W2793771211 @default.
- W3118275854 cites W2800669015 @default.
- W3118275854 cites W2802484183 @default.
- W3118275854 cites W2808606536 @default.
- W3118275854 cites W2810329031 @default.
- W3118275854 cites W2892538941 @default.
- W3118275854 cites W2894751682 @default.
- W3118275854 cites W2902195924 @default.
- W3118275854 cites W2910898109 @default.
- W3118275854 cites W2911859923 @default.
- W3118275854 cites W2914072806 @default.