Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118278361> ?p ?o ?g. }
- W3118278361 abstract "Developing effective drugs for Alzheimer's disease (AD), the most common cause of dementia, has been difficult because of complicated pathogenesis. Here, we report an efficient, network-based drug-screening platform developed by integrating mathematical modeling and the pathological features of AD with human iPSC-derived cerebral organoids (iCOs), including CRISPR-Cas9-edited isogenic lines. We use 1300 organoids from 11 participants to build a high-content screening (HCS) system and test blood-brain barrier-permeable FDA-approved drugs. Our study provides a strategy for precision medicine through the convergence of mathematical modeling and a miniature pathological brain model using iCOs." @default.
- W3118278361 created "2021-01-18" @default.
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- W3118278361 date "2021-01-12" @default.
- W3118278361 modified "2023-10-16" @default.
- W3118278361 title "A logical network-based drug-screening platform for Alzheimer’s disease representing pathological features of human brain organoids" @default.
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- W3118278361 doi "https://doi.org/10.1038/s41467-020-20440-5" @default.