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- W3118282390 abstract "Background : Anastomotic leak in the colon is one of the causes of high morbidity and mortality in infectiouscases. The morbidity and mortality rates in patients with colonic anastomotic leakage range from 7–39%.Various efforts have been made to prevent leakage, such as changing suture techniques and using additionalmaterials. Materials such as fibrin glue and amniotic membranes are gaining popularity in the wound healingprocess.Purpose : To compare the use of dry amniotic membrane and fibrin glue in colonic anastomosis inintraperitoneal infection assessed with tissue hydroxyproline level measurement.Method : This study is an experimental. The subjects were divided into 3 groups, group I (anastomosis usinga simple interrupted suture only), group II (anastomosis and was applied with dry amniotic membrane) andgroup III (anastomosis using a simple interrupted sutureand was applied with fibrin glue). The anastomoticsegment was taken and made into homogenate, then measured for the hydroxyproline level.Result : The study was conducted on 27 Wistar rats, male rats that have been aged 10-12 weeks with theweight of 250-300 grams. It was obtained the differences in average levels hydroxyproline in the group I= 2157.41 (± SD = 478.60), group II = 2887.40 (± SD = 688.49) and group III = 2224.59 (± SD = 416.63).ANOVA test at hydroxyproline samples showed that P <0.05 (0.015) means that there are statisticallysignificant differences in the levels of hydroxyproline in all three groups of samples. Post Hoc test of ANOVAshowed that the levels of hydroxyproline in the group II (Interrupted suture + Dry amniotic membrane) hasthe most high mean difference with the significance of p<0.05 means that the levels of hydroxyproline in thegroup is most significant.Conclusion : Based on the results of the study, it can be concluded that the use of the dry amniotic membranewas better than fibrin glue of colonic anastomosis in conditions of intra-peritoneal infection, there was anincrease in hydroxyproline levels of colonic anastomosis tissue applied in dry amniotic membrane withstatistically significant results." @default.
- W3118282390 created "2021-01-18" @default.
- W3118282390 date "2021-01-23" @default.
- W3118282390 modified "2023-09-25" @default.
- W3118282390 title "Comparison of Colonic Anastomosis Using Dry Amnion Membrane and Fibrin Glue in Intraperitoneal Infection Condition Assessed from Tissue Hydroxyproline Level Measurement (Study on Wistar Rat)" @default.
- W3118282390 doi "https://doi.org/10.37506/ijphrd.v12i1.13876" @default.
- W3118282390 hasPublicationYear "2021" @default.
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