Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118295845> ?p ?o ?g. }
- W3118295845 endingPage "329" @default.
- W3118295845 startingPage "313" @default.
- W3118295845 abstract "Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study, a 46 gene biomarker was found to be an accurate predictor of estrogen receptor (ER) α modulation in chemically treated MCF-7 cells. Here, potential ERα modulators were identified using the biomarker by screening a microarray compendium consisting of ∼1600 gene expression comparisons representing exposure to ∼1200 chemicals. A total of ∼170 chemicals were identified as potential ERα modulators. In the Connectivity Map 2.0 collection, 75 and 39 chemicals were predicted to activate or suppress ERα, and they included 12 and six known ERα agonists and antagonists/selective ERα modulators, respectively. Nineteen and eight of the total number were also identified as active in an ERα transactivation assay carried out in an MCF-7-derived cell line used to screen the Tox21 10K chemical library in agonist or antagonist modes, respectively. Chemicals predicted to modulate ERα in MCF-7 cells were examined further using global and targeted gene expression in wild-type and ERα-null cells, transactivation assays, and cell-free ERα coregulator interaction assays. Environmental chemicals classified as weak and very weak agonists were confirmed to activate ERα including apigenin, kaempferol, and oxybenzone. Novel activators included digoxin, nabumetone, ivermectin, and six progestins. Novel suppressors included emetine, mifepristone, niclosamide, and proscillaridin. Our strategy will be useful to identify environmentally relevant ERα modulators in future high-throughput transcriptomic screens." @default.
- W3118295845 created "2021-01-18" @default.
- W3118295845 creator A5011993587 @default.
- W3118295845 creator A5013677882 @default.
- W3118295845 creator A5053741927 @default.
- W3118295845 creator A5064649529 @default.
- W3118295845 creator A5066861394 @default.
- W3118295845 creator A5068994703 @default.
- W3118295845 creator A5075303869 @default.
- W3118295845 creator A5077755204 @default.
- W3118295845 creator A5085352453 @default.
- W3118295845 date "2021-01-06" @default.
- W3118295845 modified "2023-10-16" @default.
- W3118295845 title "A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor α in an MCF-7 Microarray Compendium" @default.
- W3118295845 cites W1044560385 @default.
- W3118295845 cites W1502153727 @default.
- W3118295845 cites W1569704074 @default.
- W3118295845 cites W1622904595 @default.
- W3118295845 cites W1835137027 @default.
- W3118295845 cites W1964818895 @default.
- W3118295845 cites W1966531520 @default.
- W3118295845 cites W1967434540 @default.
- W3118295845 cites W1969190639 @default.
- W3118295845 cites W1978622015 @default.
- W3118295845 cites W1983007007 @default.
- W3118295845 cites W1989858543 @default.
- W3118295845 cites W1996593784 @default.
- W3118295845 cites W1996598875 @default.
- W3118295845 cites W2007435247 @default.
- W3118295845 cites W2012614526 @default.
- W3118295845 cites W2019707847 @default.
- W3118295845 cites W2021202441 @default.
- W3118295845 cites W2029980980 @default.
- W3118295845 cites W2033262068 @default.
- W3118295845 cites W2037551587 @default.
- W3118295845 cites W2038064173 @default.
- W3118295845 cites W2039576757 @default.
- W3118295845 cites W2040607104 @default.
- W3118295845 cites W2047483325 @default.
- W3118295845 cites W2054372078 @default.
- W3118295845 cites W2064656431 @default.
- W3118295845 cites W2070303637 @default.
- W3118295845 cites W2070432942 @default.
- W3118295845 cites W2071176161 @default.
- W3118295845 cites W2085391180 @default.
- W3118295845 cites W2098971483 @default.
- W3118295845 cites W2105052532 @default.
- W3118295845 cites W2118346323 @default.
- W3118295845 cites W2121604817 @default.
- W3118295845 cites W2123830992 @default.
- W3118295845 cites W2128683406 @default.
- W3118295845 cites W2134843847 @default.
- W3118295845 cites W2144409727 @default.
- W3118295845 cites W2145474242 @default.
- W3118295845 cites W2161433163 @default.
- W3118295845 cites W2161550291 @default.
- W3118295845 cites W2165837380 @default.
- W3118295845 cites W2194873522 @default.
- W3118295845 cites W2231585839 @default.
- W3118295845 cites W2264803696 @default.
- W3118295845 cites W2294848537 @default.
- W3118295845 cites W2295217081 @default.
- W3118295845 cites W2345568057 @default.
- W3118295845 cites W2596004793 @default.
- W3118295845 cites W2600230148 @default.
- W3118295845 cites W2618142594 @default.
- W3118295845 cites W2619508573 @default.
- W3118295845 cites W2763198880 @default.
- W3118295845 cites W2800804181 @default.
- W3118295845 cites W2884679159 @default.
- W3118295845 cites W2885478680 @default.
- W3118295845 cites W2886008099 @default.
- W3118295845 cites W2896113647 @default.
- W3118295845 cites W2919637418 @default.
- W3118295845 cites W2926464861 @default.
- W3118295845 cites W2961406314 @default.
- W3118295845 cites W4246208455 @default.
- W3118295845 doi "https://doi.org/10.1021/acs.chemrestox.0c00243" @default.
- W3118295845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33405908" @default.
- W3118295845 hasPublicationYear "2021" @default.
- W3118295845 type Work @default.
- W3118295845 sameAs 3118295845 @default.
- W3118295845 citedByCount "8" @default.
- W3118295845 countsByYear W31182958452021 @default.
- W3118295845 countsByYear W31182958452022 @default.
- W3118295845 countsByYear W31182958452023 @default.
- W3118295845 crossrefType "journal-article" @default.
- W3118295845 hasAuthorship W3118295845A5011993587 @default.
- W3118295845 hasAuthorship W3118295845A5013677882 @default.
- W3118295845 hasAuthorship W3118295845A5053741927 @default.
- W3118295845 hasAuthorship W3118295845A5064649529 @default.
- W3118295845 hasAuthorship W3118295845A5066861394 @default.
- W3118295845 hasAuthorship W3118295845A5068994703 @default.
- W3118295845 hasAuthorship W3118295845A5075303869 @default.
- W3118295845 hasAuthorship W3118295845A5077755204 @default.
- W3118295845 hasAuthorship W3118295845A5085352453 @default.
- W3118295845 hasConcept C104317684 @default.
- W3118295845 hasConcept C109541995 @default.