FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118317998> ?p ?o ?g. }

• W3118317998 abstract "Abstract Concussion or mild traumatic brain injury is the most common form of traumatic brain injury with potentially long-term consequences. Current objective diagnosis and treatment options are limited to clinical assessment, cognitive rest, and symptom management, which raises the real danger of concussed patients being released back into activities where subsequent and cumulative injuries may cause disproportionate damages. This study conducted a cross-sectional multi-modal examination investigation of the temporal changes in behavioural and brain changes in a mouse model of concussion using magnetic resonance imaging. Sham and concussed mice were assessed at day 2, day 7, and day 14 post-sham or injury procedures following a single concussion event for motor deficits, psychological symptoms with open field assessment, T2-weighted structural imaging, diffusion tensor imaging (DTI), neurite orientation density dispersion imaging (NODDI), stimulus-evoked and resting-state functional magnetic resonance imaging (fMRI). Overall, a mismatch in the temporal onsets and durations of the behavioural symptoms and structural/functional changes in the brain was seen. Deficits in behaviour persisted until day 7 post-concussion but recovered at day 14 post-concussion. DTI and NODDI changes were most extensive at day 7 and persisted in some regions at day 14 post-concussion. A persistent increase in connectivity was seen at day 2 and day 14 on rsfMRI. Stimulus-invoked fMRI detected increased cortical activation at day 7 and 14 post-concussion. Our results demonstrate the capabilities of advanced MRI in detecting the effects of a single concussive impact in the brain, and highlight a mismatch in the onset and temporal evolution of behaviour, structure, and function after a concussion. These results have significant translational impact in developing methods for the detection of human concussion and the time course of brain recovery." @default.
• W3118317998 created "2021-01-18" @default.
• W3118317998 creator A5032109138 @default.
• W3118317998 creator A5089829042 @default.
• W3118317998 date "2021-01-06" @default.
• W3118317998 modified "2023-10-16" @default.
• W3118317998 title "A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging" @default.
• W3118317998 cites W1144597879 @default.
• W3118317998 cites W1582730964 @default.
• W3118317998 cites W1789349355 @default.
• W3118317998 cites W1837627324 @default.
• W3118317998 cites W1884913098 @default.
• W3118317998 cites W1973741448 @default.
• W3118317998 cites W1978354990 @default.
• W3118317998 cites W1978957620 @default.
• W3118317998 cites W1983112713 @default.
• W3118317998 cites W1984453610 @default.
• W3118317998 cites W1985327120 @default.
• W3118317998 cites W1986978286 @default.
• W3118317998 cites W1990510254 @default.
• W3118317998 cites W1991417330 @default.
• W3118317998 cites W1994531735 @default.
• W3118317998 cites W1995968640 @default.
• W3118317998 cites W2004006028 @default.
• W3118317998 cites W2004225262 @default.
• W3118317998 cites W2006096283 @default.
• W3118317998 cites W2007213925 @default.
• W3118317998 cites W2009494091 @default.
• W3118317998 cites W2011113754 @default.
• W3118317998 cites W2015551349 @default.
• W3118317998 cites W2021422481 @default.
• W3118317998 cites W2021597537 @default.
• W3118317998 cites W2021939133 @default.
• W3118317998 cites W2027017271 @default.
• W3118317998 cites W2032254014 @default.
• W3118317998 cites W2033951042 @default.
• W3118317998 cites W2040985763 @default.
• W3118317998 cites W2045407457 @default.
• W3118317998 cites W2046557060 @default.
• W3118317998 cites W2049649543 @default.
• W3118317998 cites W2055637322 @default.
• W3118317998 cites W2059274399 @default.
• W3118317998 cites W2060516585 @default.
• W3118317998 cites W2064076048 @default.
• W3118317998 cites W2065337015 @default.
• W3118317998 cites W2065828939 @default.
• W3118317998 cites W2071361833 @default.
• W3118317998 cites W2074654724 @default.
• W3118317998 cites W2074895886 @default.
• W3118317998 cites W2078558859 @default.
• W3118317998 cites W2084761689 @default.
• W3118317998 cites W2088858548 @default.
• W3118317998 cites W2094345233 @default.
• W3118317998 cites W2096672020 @default.
• W3118317998 cites W2102049982 @default.
• W3118317998 cites W2105876678 @default.
• W3118317998 cites W2105909330 @default.
• W3118317998 cites W2108384452 @default.
• W3118317998 cites W2111066106 @default.
• W3118317998 cites W2115971978 @default.
• W3118317998 cites W2126655806 @default.
• W3118317998 cites W2126693856 @default.
• W3118317998 cites W2128688927 @default.
• W3118317998 cites W2134478490 @default.
• W3118317998 cites W2138481970 @default.
• W3118317998 cites W2140653640 @default.
• W3118317998 cites W2142086230 @default.
• W3118317998 cites W2144427015 @default.
• W3118317998 cites W2144494407 @default.
• W3118317998 cites W2146853248 @default.
• W3118317998 cites W2149240084 @default.
• W3118317998 cites W2157723935 @default.
• W3118317998 cites W2166530256 @default.
• W3118317998 cites W2169787465 @default.
• W3118317998 cites W2170525366 @default.
• W3118317998 cites W2202068811 @default.
• W3118317998 cites W2214908060 @default.
• W3118317998 cites W2217108923 @default.
• W3118317998 cites W2253666151 @default.
• W3118317998 cites W2259362834 @default.
• W3118317998 cites W2272247583 @default.
• W3118317998 cites W2283761130 @default.
• W3118317998 cites W2294350755 @default.
• W3118317998 cites W2337267318 @default.
• W3118317998 cites W2364531337 @default.
• W3118317998 cites W2467166229 @default.
• W3118317998 cites W2468904027 @default.
• W3118317998 cites W2506718863 @default.
• W3118317998 cites W2522535150 @default.
• W3118317998 cites W2567460568 @default.
• W3118317998 cites W2568027254 @default.
• W3118317998 cites W2593995965 @default.
• W3118317998 cites W2611281735 @default.
• W3118317998 cites W2615039471 @default.
• W3118317998 cites W2620311529 @default.
• W3118317998 cites W2659925573 @default.
• W3118317998 cites W2727278441 @default.
• W3118317998 cites W2734811923 @default.
• W3118317998 cites W2753663815 @default.
• W3118317998 cites W2754141479 @default.

• next