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• W3118331092 abstract "Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1-/- or Sod1KO mice) have increased oxidative stress, show accelerated aging and develop spontaneous hepatocellular carcinoma (HCC) with age. Similar to humans, HCC development in Sod1KO mice progresses from non-alcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH) with fibrosis, which eventually progresses to HCC. Oxidative stress plays a role in NAFLD to NASH progression, and liver inflammation is the main mechanism that drives the disease progression from NASH to fibrosis. Because necroptosis is a major source of inflammation, we tested the hypothesis that increased necroptosis in the liver plays a role in increased inflammation and fibrosis in Sod1KO mice. Phosphorylation of MLKL (P-MLKL), a well-accepted marker of necroptosis, and expression of MLKL protein were significantly increased in the livers of Sod1KO mice compared to wild type (WT) mice indicating increased necroptosis. Similarly, phosphorylation of RIPK3 and RIPK3 protein levels were also significantly increased. Markers of pro-inflammatory M1 macrophages, NLRP3 inflammasome, and transcript levels of pro-inflammatory cytokines and chemokines, e.g., TNFα, IL-6, IL-1β, and Ccl2 that are associated with human NASH, were significantly increased. Expression of antioxidant enzymes and heat shock proteins, and markers of fibrosis and oncogenic transcription factor STAT3 were also upregulated and autophagy was downregulated in the livers of Sod1KO mice. Short term treatment of Sod1KO mice with necrostatin-1s (Nec-1s), a necroptosis inhibitor, reversed these conditions. Our data show for the first time that necroptosis-mediated inflammation contributes to fibrosis in a mouse model of increased oxidative stress and accelerated aging, that also exhibits progressive HCC development." @default.
• W3118331092 created "2021-01-18" @default.
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• W3118331092 date "2021-02-01" @default.
• W3118331092 modified "2023-10-17" @default.
• W3118331092 title "Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress" @default.
• W3118331092 cites W1035050697 @default.
• W3118331092 cites W1511286995 @default.
• W3118331092 cites W1565491355 @default.
• W3118331092 cites W1967972402 @default.
• W3118331092 cites W1973360607 @default.
• W3118331092 cites W1978045299 @default.
• W3118331092 cites W1982168868 @default.
• W3118331092 cites W1992481999 @default.
• W3118331092 cites W2016828736 @default.
• W3118331092 cites W2018460745 @default.
• W3118331092 cites W2021919397 @default.
• W3118331092 cites W2023122823 @default.
• W3118331092 cites W2023299228 @default.
• W3118331092 cites W2024519961 @default.
• W3118331092 cites W2039254613 @default.
• W3118331092 cites W2040751146 @default.
• W3118331092 cites W2042637324 @default.
• W3118331092 cites W2047930332 @default.
• W3118331092 cites W2052347239 @default.
• W3118331092 cites W2052656103 @default.
• W3118331092 cites W2053893264 @default.
• W3118331092 cites W2058527296 @default.
• W3118331092 cites W2080998956 @default.
• W3118331092 cites W2091263717 @default.
• W3118331092 cites W2095866442 @default.
• W3118331092 cites W2104193042 @default.
• W3118331092 cites W2110796758 @default.
• W3118331092 cites W2117941396 @default.
• W3118331092 cites W2131357993 @default.
• W3118331092 cites W2133655232 @default.
• W3118331092 cites W2134705170 @default.
• W3118331092 cites W2137257146 @default.
• W3118331092 cites W2142225943 @default.
• W3118331092 cites W2144178804 @default.
• W3118331092 cites W2147898680 @default.
• W3118331092 cites W2147934487 @default.
• W3118331092 cites W2148999990 @default.
• W3118331092 cites W2153328565 @default.
• W3118331092 cites W2165851686 @default.
• W3118331092 cites W2169820248 @default.
• W3118331092 cites W2170005129 @default.
• W3118331092 cites W2178250841 @default.
• W3118331092 cites W2204688218 @default.
• W3118331092 cites W2263623270 @default.
• W3118331092 cites W2285203836 @default.
• W3118331092 cites W2299478631 @default.
• W3118331092 cites W2309659182 @default.
• W3118331092 cites W2315356900 @default.
• W3118331092 cites W2405340912 @default.
• W3118331092 cites W2434220618 @default.
• W3118331092 cites W2467522065 @default.
• W3118331092 cites W2475104312 @default.
• W3118331092 cites W2500850723 @default.
• W3118331092 cites W2540046736 @default.
• W3118331092 cites W2548948398 @default.
• W3118331092 cites W2561251264 @default.
• W3118331092 cites W2562949639 @default.
• W3118331092 cites W2565402466 @default.
• W3118331092 cites W2619892599 @default.
• W3118331092 cites W2777389776 @default.
• W3118331092 cites W2780408352 @default.
• W3118331092 cites W2787840443 @default.
• W3118331092 cites W2794330007 @default.
• W3118331092 cites W2801929531 @default.
• W3118331092 cites W2802574433 @default.
• W3118331092 cites W2898568606 @default.
• W3118331092 cites W2901410206 @default.
• W3118331092 cites W2901438563 @default.
• W3118331092 cites W2901814223 @default.
• W3118331092 cites W2902318621 @default.
• W3118331092 cites W2917198017 @default.
• W3118331092 cites W2971079908 @default.
• W3118331092 cites W2981297924 @default.
• W3118331092 cites W2982170165 @default.
• W3118331092 cites W2989291073 @default.
• W3118331092 cites W2991283014 @default.
• W3118331092 cites W3012187299 @default.
• W3118331092 cites W3025717651 @default.
• W3118331092 cites W4233839805 @default.
• W3118331092 cites W563564394 @default.
• W3118331092 doi "https://doi.org/10.1016/j.freeradbiomed.2020.12.449" @default.
• W3118331092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33429022" @default.
• W3118331092 hasPublicationYear "2021" @default.
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