FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118337224> ?p ?o ?g. }

• W3118337224 endingPage "161" @default.
• W3118337224 startingPage "147" @default.
• W3118337224 abstract "The duration and the optimal time to adjuvant chemotherapy (TAC) in locally advanced gastric cancer (LAGC) have net not been sufficiently demonstrated. Sequential adjuvant chemotherapy (AC) after neoadjuvant chemotherapy plus gastrectomy is increasingly utilized, making the question more complicated.Data were collected from patients with LAGC who underwent 5-Fu-based doublet regimens as adjuvant treatment after gastrectomy in a single-center database. TAC and duration (cycles) were used to evaluate survival outcomes.A total of 816 patients were included. Patients received over six cycles and TAC less than 42 days significantly correlated with better survival (log-rank Ptrend<0.001). The analysis of TAC and number cycles were separately applied in perioperative chemotherapy (PEC) and postoperative chemotherapy (POC) group using Cox regression. The number of cycles revealed a statistical significance improving OS rate both in POC (HR=0.904, 95% CI=0.836-0.977, P=0.011) and PEC (HR=0.887, 95% CI=0.798-0.986, P=0.026), while only in POC did the TAC show an increasing trend of risk with borderline significance (OS: HR=1.008, 95% CI=0.999-1.018, P=0.094; PFS: HR=1.009, 95% CI=1.000-1.018, P=0.055). A spline model demonstrates the less improvement in survival after cycles of chemotherapy reaching six.Our findings suggest that TAC is more likely to downregulate the survival benefit in POC rather than PEC, while overall survival is susceptible to cumulative cycles of chemotherapy in both groups. Furthermore, six cycles of chemotherapy tended to reach the maximum survival benefits. Prospective confirmation is required." @default.
• W3118337224 created "2021-01-18" @default.
• W3118337224 creator A5018652161 @default.
• W3118337224 creator A5031049292 @default.
• W3118337224 creator A5039869472 @default.
• W3118337224 creator A5046466920 @default.
• W3118337224 creator A5072078326 @default.
• W3118337224 creator A5075640750 @default.
• W3118337224 creator A5079618096 @default.
• W3118337224 creator A5079776454 @default.
• W3118337224 creator A5087287319 @default.
• W3118337224 date "2021-01-01" @default.
• W3118337224 modified "2023-10-16" @default.
• W3118337224 title "5-Fu-Based Doublet Regimen in Patients Receiving Perioperative or Postoperative Chemotherapy for Locally Advanced Gastric Cancer: When to Start and How Long Should the Regimen Last?" @default.
• W3118337224 cites W1422664991 @default.
• W3118337224 cites W2001170783 @default.
• W3118337224 cites W2010681804 @default.
• W3118337224 cites W2026986976 @default.
• W3118337224 cites W2079643548 @default.
• W3118337224 cites W2113947048 @default.
• W3118337224 cites W2115072149 @default.
• W3118337224 cites W2125593650 @default.
• W3118337224 cites W2137991416 @default.
• W3118337224 cites W2146834306 @default.
• W3118337224 cites W2149595903 @default.
• W3118337224 cites W2161778541 @default.
• W3118337224 cites W2165982376 @default.
• W3118337224 cites W2168047626 @default.
• W3118337224 cites W2171075804 @default.
• W3118337224 cites W2402630992 @default.
• W3118337224 cites W2513322323 @default.
• W3118337224 cites W2556009055 @default.
• W3118337224 cites W2567564159 @default.
• W3118337224 cites W2579423964 @default.
• W3118337224 cites W2587074836 @default.
• W3118337224 cites W2612264047 @default.
• W3118337224 cites W2741953965 @default.
• W3118337224 cites W2749713164 @default.
• W3118337224 cites W2750022751 @default.
• W3118337224 cites W2774139165 @default.
• W3118337224 cites W2786816614 @default.
• W3118337224 cites W2800160157 @default.
• W3118337224 cites W2800803175 @default.
• W3118337224 cites W2802055527 @default.
• W3118337224 cites W2805651301 @default.
• W3118337224 cites W2889646458 @default.
• W3118337224 cites W2909450003 @default.
• W3118337224 cites W2922572382 @default.
• W3118337224 cites W2935936692 @default.
• W3118337224 cites W2936700695 @default.
• W3118337224 cites W2938774982 @default.
• W3118337224 cites W2943606118 @default.
• W3118337224 cites W2953330825 @default.
• W3118337224 cites W2973899258 @default.
• W3118337224 cites W2976491173 @default.
• W3118337224 cites W2978267423 @default.
• W3118337224 cites W2984642856 @default.
• W3118337224 cites W2995029941 @default.
• W3118337224 cites W3000488930 @default.
• W3118337224 cites W3003299869 @default.
• W3118337224 doi "https://doi.org/10.2147/cmar.s285361" @default.
• W3118337224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7810590" @default.
• W3118337224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33469359" @default.
• W3118337224 hasPublicationYear "2021" @default.
• W3118337224 type Work @default.
• W3118337224 sameAs 3118337224 @default.
• W3118337224 citedByCount "6" @default.
• W3118337224 countsByYear W31183372242021 @default.
• W3118337224 countsByYear W31183372242022 @default.
• W3118337224 crossrefType "journal-article" @default.
• W3118337224 hasAuthorship W3118337224A5018652161 @default.
• W3118337224 hasAuthorship W3118337224A5031049292 @default.
• W3118337224 hasAuthorship W3118337224A5039869472 @default.
• W3118337224 hasAuthorship W3118337224A5046466920 @default.
• W3118337224 hasAuthorship W3118337224A5072078326 @default.
• W3118337224 hasAuthorship W3118337224A5075640750 @default.
• W3118337224 hasAuthorship W3118337224A5079618096 @default.
• W3118337224 hasAuthorship W3118337224A5079776454 @default.
• W3118337224 hasAuthorship W3118337224A5087287319 @default.
• W3118337224 hasBestOaLocation W31183372241 @default.
• W3118337224 hasConcept C121608353 @default.
• W3118337224 hasConcept C126322002 @default.
• W3118337224 hasConcept C141071460 @default.
• W3118337224 hasConcept C143998085 @default.
• W3118337224 hasConcept C2776694085 @default.
• W3118337224 hasConcept C2777863537 @default.
• W3118337224 hasConcept C2780470880 @default.
• W3118337224 hasConcept C2781413609 @default.
• W3118337224 hasConcept C31174226 @default.
• W3118337224 hasConcept C50382708 @default.
• W3118337224 hasConcept C65409693 @default.
• W3118337224 hasConcept C71924100 @default.
• W3118337224 hasConcept C90924648 @default.
• W3118337224 hasConceptScore W3118337224C121608353 @default.
• W3118337224 hasConceptScore W3118337224C126322002 @default.
• W3118337224 hasConceptScore W3118337224C141071460 @default.
• W3118337224 hasConceptScore W3118337224C143998085 @default.
• W3118337224 hasConceptScore W3118337224C2776694085 @default.

• next