Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118339931> ?p ?o ?g. }
- W3118339931 abstract "Mitochondria are bioenergetic organelles with a plethora of fundamental functions ranging from metabolism and ATP production to modulation of signaling events leading to cell survival or cell death. Ion channels located in the outer and inner mitochondrial membranes critically control mitochondrial function and, as a consequence, also cell fate. Opening or closure of mitochondrial ion channels allow the fine-tuning of mitochondrial membrane potential, ROS production, and function of the respiratory chain complexes. In this review, we critically discuss the intracellular regulatory factors that affect channel activity in the inner membrane of mitochondria and, indirectly, contribute to cell death. These factors include various ligands, kinases, second messengers, and lipids. Comprehension of mitochondrial ion channels regulation in cell death pathways might reveal new therapeutic targets in mitochondria-linked pathologies like cancer, ischemia, reperfusion injury, and neurological disorders." @default.
- W3118339931 created "2021-01-18" @default.
- W3118339931 creator A5013135864 @default.
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- W3118339931 creator A5051913680 @default.
- W3118339931 creator A5059021455 @default.
- W3118339931 creator A5075678380 @default.
- W3118339931 date "2021-01-05" @default.
- W3118339931 modified "2023-10-06" @default.
- W3118339931 title "Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling" @default.
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