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- W3118343878 abstract "Recent findings have shown that nanovesicles preparations from either primary immune cells culture supernatants or plasma contain immunoglobulins, suggesting that a natural way of antibody production may be through exosome release. To verify this hypothesis, we used the OKT3 hybridoma clone, which produces a murine IgG2a monoclonal antibody used to reduce rejection in patients undergoing organ transplantation. We showed exosome-associated immunoglobulins in hybridoma supernatants, by Western blot, nanoscale flow cytometry and immunocapture-based ELISA. The OKT3-exo was also being able to trigger cytokines production in both CD4 and CD8 T cells. These results show that nanovesicles contain immunoglobulin and could be used for immunotherapy. These data could lead to a new approach to improve the effectiveness of therapeutic antibodies by exploiting their natural property to be expressed on nanovesicle membrane, that probably render them more stable and as a consequence more capable to interact with their specific ligand in the best way." @default.
- W3118343878 created "2021-01-18" @default.
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- W3118343878 date "2021-01-01" @default.
- W3118343878 modified "2023-10-17" @default.
- W3118343878 title "Nanovesicles released by OKT3 hybridoma express fully active antibodies" @default.
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- W3118343878 doi "https://doi.org/10.1080/14756366.2020.1852401" @default.
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