FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118354259> ?p ?o ?g. }

• W3118354259 endingPage "S271" @default.
• W3118354259 startingPage "S270" @default.
• W3118354259 abstract "Abstract Background In critically ill patients with COVID-19 it is difficult to determine the presence of bacterial co-infection. Many patients receive antibiotics until a bacterial infection can be ruled out. To minimize aerosolization of SARS-CoV-2, non-invasive sampling, such as endotracheal aspiration (ETA), is preferred over invasive techniques. The purpose of this study is to determine the diagnostic yield of ETA and effect of ETA on antibiotic management in patients with COVID-19. Methods This retrospective analysis included patients admitted to the intensive care unit (ICU) from March 1 to May 31, 2020 who tested positive for SARS-CoV-2. Patients who did not receive mechanical ventilation were excluded. Data were extracted from electronic medical records. When ETA was performed, records were manually reviewed to determine diagnostic yield and effect on antibiotic management. Diagnostic yield was defined as ETA result with a plausible respiratory pathogen in a quantity of moderate or many. Plausible respiratory pathogens exclude normal flora, yeast, coagulase-negative Staphylococcus sp and Enterococcus sp. The primary outcome is the frequency of initiation, change, no change, or discontinuation of antibiotics based on ETA results. Results 124 patients with COVID-19 were admitted to the ICU; 76 met inclusion criteria. The average age was 58 years and 75% were male. Hispanic or Latino ethnicity made up the majority of the patient population (63%). Antibiotics were administered to 97% of patients for a median of 11 days of therapy (IQR 7, 21). There were 100 ETAs performed on 55 patients for a diagnostic yield of 21%. ETA led to a change in antibiotic management 47% of the time it was performed. Antibiotic changes include de-escalation (29), discontinuation (7), escalation (6), and initiation (5). Conclusion The diagnostic yield of ETA in mechanically ventilated patients with COVID-19 was low. Furthermore, ETA results led to a change in antibiotics less than half of the time. The use of ETA to diagnose bacterial co-infection and guide antibiotic therapy in patients with COVID-19 should be weighed against the risk of using a more invasive sampling technique vs the benefit of potential for increased diagnostic yield. Another conclusion may be to forgo ETA if the result is unlikely to change management. Disclosures All Authors: No reported disclosures" @default.
• W3118354259 created "2021-01-18" @default.
• W3118354259 creator A5022826841 @default.
• W3118354259 creator A5074383098 @default.
• W3118354259 creator A5082375030 @default.
• W3118354259 creator A5087749776 @default.
• W3118354259 creator A5088165121 @default.
• W3118354259 date "2020-10-01" @default.
• W3118354259 modified "2023-10-17" @default.
• W3118354259 title "406. Utility of Tracheal Aspirates in Guiding Antibiotic Use in Mechanically Ventilated Patients with COVID-19" @default.
• W3118354259 doi "https://doi.org/10.1093/ofid/ofaa439.601" @default.
• W3118354259 hasPublicationYear "2020" @default.
• W3118354259 type Work @default.
• W3118354259 sameAs 3118354259 @default.
• W3118354259 citedByCount "0" @default.
• W3118354259 crossrefType "journal-article" @default.
• W3118354259 hasAuthorship W3118354259A5022826841 @default.
• W3118354259 hasAuthorship W3118354259A5074383098 @default.
• W3118354259 hasAuthorship W3118354259A5082375030 @default.
• W3118354259 hasAuthorship W3118354259A5087749776 @default.
• W3118354259 hasAuthorship W3118354259A5088165121 @default.
• W3118354259 hasBestOaLocation W31183542591 @default.
• W3118354259 hasConcept C126322002 @default.
• W3118354259 hasConcept C167135981 @default.
• W3118354259 hasConcept C177713679 @default.
• W3118354259 hasConcept C195910791 @default.
• W3118354259 hasConcept C2776376669 @default.
• W3118354259 hasConcept C2777080012 @default.
• W3118354259 hasConcept C2778715236 @default.
• W3118354259 hasConcept C2908647359 @default.
• W3118354259 hasConcept C501593827 @default.
• W3118354259 hasConcept C71924100 @default.
• W3118354259 hasConcept C86803240 @default.
• W3118354259 hasConcept C89423630 @default.
• W3118354259 hasConcept C99454951 @default.
• W3118354259 hasConceptScore W3118354259C126322002 @default.
• W3118354259 hasConceptScore W3118354259C167135981 @default.
• W3118354259 hasConceptScore W3118354259C177713679 @default.
• W3118354259 hasConceptScore W3118354259C195910791 @default.
• W3118354259 hasConceptScore W3118354259C2776376669 @default.
• W3118354259 hasConceptScore W3118354259C2777080012 @default.
• W3118354259 hasConceptScore W3118354259C2778715236 @default.
• W3118354259 hasConceptScore W3118354259C2908647359 @default.
• W3118354259 hasConceptScore W3118354259C501593827 @default.
• W3118354259 hasConceptScore W3118354259C71924100 @default.
• W3118354259 hasConceptScore W3118354259C86803240 @default.
• W3118354259 hasConceptScore W3118354259C89423630 @default.
• W3118354259 hasConceptScore W3118354259C99454951 @default.
• W3118354259 hasIssue "Supplement_1" @default.
• W3118354259 hasLocation W31183542591 @default.
• W3118354259 hasLocation W31183542592 @default.
• W3118354259 hasLocation W31183542593 @default.
• W3118354259 hasOpenAccess W3118354259 @default.
• W3118354259 hasPrimaryLocation W31183542591 @default.
• W3118354259 hasRelatedWork W1766497789 @default.
• W3118354259 hasRelatedWork W2009263326 @default.
• W3118354259 hasRelatedWork W2068150602 @default.
• W3118354259 hasRelatedWork W2181553135 @default.
• W3118354259 hasRelatedWork W2784535017 @default.
• W3118354259 hasRelatedWork W2792379654 @default.
• W3118354259 hasRelatedWork W3146714785 @default.
• W3118354259 hasRelatedWork W4372355037 @default.
• W3118354259 hasRelatedWork W4383873209 @default.
• W3118354259 hasRelatedWork W4386248459 @default.
• W3118354259 hasVolume "7" @default.
• W3118354259 isParatext "false" @default.
• W3118354259 isRetracted "false" @default.
• W3118354259 magId "3118354259" @default.
• W3118354259 workType "article" @default.