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- W3118366280 abstract "Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs), followed by loss of pancreatic β-cells. (Pre-)proinsulin ([P]PI), glutamic acid decarboxylase (GAD), tyrosine phosphatase IA-2, and the zinc transporter ZnT8 are key molecules in T1D pathogenesis and are recognized by autoantibodies detected in routine clinical laboratory assays. However, generation of new autoantigens (neoantigens) from β-cells has also been reported, against which the autoreactive T cells show activity. Heat shock proteins (HSPs) were originally described as “cellular stress responders” for their role as chaperones that regulate the conformation and function of a large number of cellular proteins to protect the body from stress. HSPs participate in key cellular functions under both physiological and stressful conditions, including suppression of protein aggregation, assisting folding and stability of nascent and damaged proteins, translocation of proteins into cellular compartments and targeting irreversibly damaged proteins for degradation. Low HSP expression impacts many pathological conditions associated with diabetes and could play a role in diabetic complications. HSPs have beneficial effects in preventing insulin resistance and hyperglycemia in type 2 diabetes (T2D). HSPs are, however, additionally involved in antigen presentation, presenting immunogenic peptides to class I and class II major histocompatibility molecules; thus, an opportunity exists for HSPs to be employed as modulators of immunologic responses in T1D and other autoimmune disorders. In this review, we discuss the multifaceted roles of HSPs in the pathogenesis of T1D and in autoantigen-specific immune protection against T1D development." @default.
- W3118366280 created "2021-01-18" @default.
- W3118366280 creator A5006910868 @default.
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- W3118366280 creator A5076939431 @default.
- W3118366280 date "2021-01-14" @default.
- W3118366280 modified "2023-10-18" @default.
- W3118366280 title "The Role of Heat Shock Proteins in Type 1 Diabetes" @default.
- W3118366280 cites W120970592 @default.
- W3118366280 cites W1461005234 @default.
- W3118366280 cites W1483463686 @default.
- W3118366280 cites W1598741049 @default.
- W3118366280 cites W1863320924 @default.
- W3118366280 cites W1935621669 @default.
- W3118366280 cites W1954887516 @default.
- W3118366280 cites W1966517387 @default.
- W3118366280 cites W1968922072 @default.
- W3118366280 cites W1969173372 @default.
- W3118366280 cites W1969237316 @default.
- W3118366280 cites W1969766309 @default.
- W3118366280 cites W1970257307 @default.
- W3118366280 cites W1970842961 @default.
- W3118366280 cites W1971756409 @default.
- W3118366280 cites W1976417206 @default.
- W3118366280 cites W1978400823 @default.
- W3118366280 cites W1983840740 @default.
- W3118366280 cites W1984672460 @default.
- W3118366280 cites W1989661643 @default.
- W3118366280 cites W1995107960 @default.
- W3118366280 cites W1997572053 @default.
- W3118366280 cites W1998102634 @default.
- W3118366280 cites W2000118672 @default.
- W3118366280 cites W2000848248 @default.
- W3118366280 cites W2001015172 @default.
- W3118366280 cites W2001767617 @default.
- W3118366280 cites W2003667600 @default.
- W3118366280 cites W2005330948 @default.
- W3118366280 cites W2007606955 @default.
- W3118366280 cites W2008907218 @default.
- W3118366280 cites W2010302741 @default.
- W3118366280 cites W2011614956 @default.
- W3118366280 cites W2012303915 @default.
- W3118366280 cites W2014022710 @default.
- W3118366280 cites W2016138502 @default.
- W3118366280 cites W2020817051 @default.
- W3118366280 cites W2021000610 @default.
- W3118366280 cites W2026549470 @default.
- W3118366280 cites W2028894584 @default.
- W3118366280 cites W2029507429 @default.
- W3118366280 cites W2032451121 @default.
- W3118366280 cites W2032714982 @default.
- W3118366280 cites W2035677139 @default.
- W3118366280 cites W2036506653 @default.
- W3118366280 cites W2036998287 @default.
- W3118366280 cites W2038117110 @default.
- W3118366280 cites W2046816021 @default.
- W3118366280 cites W2047627851 @default.
- W3118366280 cites W2047768051 @default.
- W3118366280 cites W2053351742 @default.
- W3118366280 cites W2055724291 @default.
- W3118366280 cites W2059704957 @default.
- W3118366280 cites W2060351580 @default.
- W3118366280 cites W2062573090 @default.
- W3118366280 cites W2067290473 @default.
- W3118366280 cites W2070205626 @default.
- W3118366280 cites W2070546639 @default.
- W3118366280 cites W2075056405 @default.
- W3118366280 cites W2078133891 @default.
- W3118366280 cites W2080919590 @default.
- W3118366280 cites W2082363738 @default.
- W3118366280 cites W2086615542 @default.
- W3118366280 cites W2088477504 @default.
- W3118366280 cites W2089934054 @default.
- W3118366280 cites W2090917172 @default.
- W3118366280 cites W2091770132 @default.
- W3118366280 cites W2096420254 @default.
- W3118366280 cites W2103050854 @default.
- W3118366280 cites W2104663495 @default.
- W3118366280 cites W2104990598 @default.
- W3118366280 cites W2105951041 @default.
- W3118366280 cites W2111457140 @default.
- W3118366280 cites W2111545764 @default.
- W3118366280 cites W2112645925 @default.
- W3118366280 cites W2113080094 @default.
- W3118366280 cites W2119634016 @default.
- W3118366280 cites W2119761796 @default.
- W3118366280 cites W2119799816 @default.
- W3118366280 cites W2120103843 @default.
- W3118366280 cites W2121934956 @default.
- W3118366280 cites W2121951181 @default.
- W3118366280 cites W2124146192 @default.
- W3118366280 cites W2124189941 @default.
- W3118366280 cites W2126097085 @default.
- W3118366280 cites W2129551653 @default.
- W3118366280 cites W2133532208 @default.
- W3118366280 cites W2134979063 @default.
- W3118366280 cites W2138846538 @default.
- W3118366280 cites W2141261198 @default.