Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118372230> ?p ?o ?g. }
- W3118372230 endingPage "e3001029" @default.
- W3118372230 startingPage "e3001029" @default.
- W3118372230 abstract "Endosomal trafficking of receptors and associated proteins plays a critical role in signal processing. Until recently, it was thought that trafficking was shut down during cell division. Thus, remarkably, the regulation of trafficking during division remains poorly characterized. Here we delineate the role of mitotic kinases in receptor trafficking during asymmetric division. Targeted perturbations reveal that Cyclin-dependent Kinase 1 (CDK1) and Aurora Kinase promote storage of Fibroblast Growth Factor Receptors (FGFRs) by suppressing endosomal degradation and recycling pathways. As cells progress through metaphase, loss of CDK1 activity permits differential degradation and targeted recycling of stored receptors, leading to asymmetric induction. Mitotic receptor storage, as delineated in this study, may facilitate rapid reestablishment of signaling competence in nascent daughter cells. However, mutations that limit or enhance the release of stored signaling components could alter daughter cell fate or behavior thereby promoting oncogenesis." @default.
- W3118372230 created "2021-01-18" @default.
- W3118372230 creator A5013169135 @default.
- W3118372230 creator A5023298088 @default.
- W3118372230 creator A5034883201 @default.
- W3118372230 creator A5037667201 @default.
- W3118372230 creator A5043659983 @default.
- W3118372230 creator A5069185609 @default.
- W3118372230 date "2021-01-04" @default.
- W3118372230 modified "2023-09-30" @default.
- W3118372230 title "Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor" @default.
- W3118372230 cites W1432003149 @default.
- W3118372230 cites W1787157135 @default.
- W3118372230 cites W1886278373 @default.
- W3118372230 cites W1967869559 @default.
- W3118372230 cites W1987246052 @default.
- W3118372230 cites W1993365644 @default.
- W3118372230 cites W1993591756 @default.
- W3118372230 cites W1994668150 @default.
- W3118372230 cites W1996493964 @default.
- W3118372230 cites W2000700269 @default.
- W3118372230 cites W2002043029 @default.
- W3118372230 cites W2002594335 @default.
- W3118372230 cites W2011769321 @default.
- W3118372230 cites W2014407542 @default.
- W3118372230 cites W2035660316 @default.
- W3118372230 cites W2036346363 @default.
- W3118372230 cites W2041211189 @default.
- W3118372230 cites W2042239558 @default.
- W3118372230 cites W2046133662 @default.
- W3118372230 cites W2048520987 @default.
- W3118372230 cites W2050946031 @default.
- W3118372230 cites W2052489620 @default.
- W3118372230 cites W2059781302 @default.
- W3118372230 cites W2065226275 @default.
- W3118372230 cites W2094577119 @default.
- W3118372230 cites W2104829093 @default.
- W3118372230 cites W2114282435 @default.
- W3118372230 cites W2115276252 @default.
- W3118372230 cites W2117571939 @default.
- W3118372230 cites W2131131437 @default.
- W3118372230 cites W2133059825 @default.
- W3118372230 cites W2134560790 @default.
- W3118372230 cites W2136710505 @default.
- W3118372230 cites W2136792875 @default.
- W3118372230 cites W2139814040 @default.
- W3118372230 cites W2149441684 @default.
- W3118372230 cites W2150737519 @default.
- W3118372230 cites W2152651939 @default.
- W3118372230 cites W2161760230 @default.
- W3118372230 cites W2166304697 @default.
- W3118372230 cites W2169160438 @default.
- W3118372230 cites W3080684342 @default.
- W3118372230 doi "https://doi.org/10.1371/journal.pbio.3001029" @default.
- W3118372230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7808676" @default.
- W3118372230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33395410" @default.
- W3118372230 hasPublicationYear "2021" @default.
- W3118372230 type Work @default.
- W3118372230 sameAs 3118372230 @default.
- W3118372230 citedByCount "5" @default.
- W3118372230 countsByYear W31183722302021 @default.
- W3118372230 countsByYear W31183722302023 @default.
- W3118372230 crossrefType "journal-article" @default.
- W3118372230 hasAuthorship W3118372230A5013169135 @default.
- W3118372230 hasAuthorship W3118372230A5023298088 @default.
- W3118372230 hasAuthorship W3118372230A5034883201 @default.
- W3118372230 hasAuthorship W3118372230A5037667201 @default.
- W3118372230 hasAuthorship W3118372230A5043659983 @default.
- W3118372230 hasAuthorship W3118372230A5069185609 @default.
- W3118372230 hasBestOaLocation W31183722301 @default.
- W3118372230 hasConcept C120504264 @default.
- W3118372230 hasConcept C1491633281 @default.
- W3118372230 hasConcept C29537977 @default.
- W3118372230 hasConcept C54355233 @default.
- W3118372230 hasConcept C86803240 @default.
- W3118372230 hasConcept C93304396 @default.
- W3118372230 hasConcept C95444343 @default.
- W3118372230 hasConceptScore W3118372230C120504264 @default.
- W3118372230 hasConceptScore W3118372230C1491633281 @default.
- W3118372230 hasConceptScore W3118372230C29537977 @default.
- W3118372230 hasConceptScore W3118372230C54355233 @default.
- W3118372230 hasConceptScore W3118372230C86803240 @default.
- W3118372230 hasConceptScore W3118372230C93304396 @default.
- W3118372230 hasConceptScore W3118372230C95444343 @default.
- W3118372230 hasFunder F4320306076 @default.
- W3118372230 hasFunder F4320306230 @default.
- W3118372230 hasIssue "1" @default.
- W3118372230 hasLocation W31183722301 @default.
- W3118372230 hasLocation W31183722302 @default.
- W3118372230 hasLocation W31183722303 @default.
- W3118372230 hasLocation W31183722304 @default.
- W3118372230 hasOpenAccess W3118372230 @default.
- W3118372230 hasPrimaryLocation W31183722301 @default.
- W3118372230 hasRelatedWork W1964473269 @default.
- W3118372230 hasRelatedWork W1965517848 @default.
- W3118372230 hasRelatedWork W2056044063 @default.
- W3118372230 hasRelatedWork W2062796073 @default.
- W3118372230 hasRelatedWork W2116231448 @default.