Matches in SemOpenAlex for { <https://semopenalex.org/work/W3118373671> ?p ?o ?g. }
- W3118373671 endingPage "472" @default.
- W3118373671 startingPage "455" @default.
- W3118373671 abstract "The HECT (homologous to E6AP C-terminus) ubiquitin ligases (E3s) are a small family of highly conserved enzymes involved in diverse cellular functions and pathological conditions. Characterised by a C-terminal HECT domain that accepts ubiquitin from E2 ubiquitin conjugating enzymes, these E3s regulate key signalling pathways. The activity and functional regulation of HECT E3s are controlled by several factors including post-translational modifications, inter- and intramolecular interactions and binding of co-activators and adaptor proteins. In this review, we focus on the regulation of HECT E3s by accessory proteins or adaptors and discuss various ways by which adaptors mediate their regulatory roles to affect physiological outcomes. We discuss common features that are conserved from yeast to mammals, regardless of the type of E3s as well as shed light on recent discoveries explaining some existing enigmas in the field." @default.
- W3118373671 created "2021-01-18" @default.
- W3118373671 creator A5018098557 @default.
- W3118373671 creator A5073464959 @default.
- W3118373671 date "2021-01-05" @default.
- W3118373671 modified "2023-10-12" @default.
- W3118373671 title "Adaptors as the regulators of HECT ubiquitin ligases" @default.
- W3118373671 cites W1501149879 @default.
- W3118373671 cites W1553444759 @default.
- W3118373671 cites W1850749234 @default.
- W3118373671 cites W1935118997 @default.
- W3118373671 cites W1969287839 @default.
- W3118373671 cites W1970596137 @default.
- W3118373671 cites W1973098243 @default.
- W3118373671 cites W1973485468 @default.
- W3118373671 cites W1975302004 @default.
- W3118373671 cites W1989466077 @default.
- W3118373671 cites W1991411643 @default.
- W3118373671 cites W1991714991 @default.
- W3118373671 cites W1993562474 @default.
- W3118373671 cites W1995669522 @default.
- W3118373671 cites W1997762873 @default.
- W3118373671 cites W1998307755 @default.
- W3118373671 cites W2003609221 @default.
- W3118373671 cites W2004250476 @default.
- W3118373671 cites W2004763715 @default.
- W3118373671 cites W2004817469 @default.
- W3118373671 cites W2007488312 @default.
- W3118373671 cites W2008044453 @default.
- W3118373671 cites W2008316672 @default.
- W3118373671 cites W2008798771 @default.
- W3118373671 cites W2009396278 @default.
- W3118373671 cites W2010080186 @default.
- W3118373671 cites W2013248580 @default.
- W3118373671 cites W2013883770 @default.
- W3118373671 cites W2015709967 @default.
- W3118373671 cites W2016060470 @default.
- W3118373671 cites W2017105317 @default.
- W3118373671 cites W2017269420 @default.
- W3118373671 cites W2018327145 @default.
- W3118373671 cites W2019125391 @default.
- W3118373671 cites W2020432242 @default.
- W3118373671 cites W2021846401 @default.
- W3118373671 cites W2024253884 @default.
- W3118373671 cites W2027832797 @default.
- W3118373671 cites W2027988262 @default.
- W3118373671 cites W2031143289 @default.
- W3118373671 cites W2031829815 @default.
- W3118373671 cites W2032030313 @default.
- W3118373671 cites W2034662297 @default.
- W3118373671 cites W2035094622 @default.
- W3118373671 cites W2036354503 @default.
- W3118373671 cites W2037151930 @default.
- W3118373671 cites W2038980978 @default.
- W3118373671 cites W2039408629 @default.
- W3118373671 cites W2041846296 @default.
- W3118373671 cites W2042128990 @default.
- W3118373671 cites W2042697269 @default.
- W3118373671 cites W2043234471 @default.
- W3118373671 cites W2049987290 @default.
- W3118373671 cites W2050339689 @default.
- W3118373671 cites W2052855401 @default.
- W3118373671 cites W2052894358 @default.
- W3118373671 cites W2058229394 @default.
- W3118373671 cites W2059194853 @default.
- W3118373671 cites W2059419889 @default.
- W3118373671 cites W2062023115 @default.
- W3118373671 cites W2062344624 @default.
- W3118373671 cites W2062487788 @default.
- W3118373671 cites W2063927243 @default.
- W3118373671 cites W2064197396 @default.
- W3118373671 cites W2064850779 @default.
- W3118373671 cites W2065240196 @default.
- W3118373671 cites W2065395657 @default.
- W3118373671 cites W2065633653 @default.
- W3118373671 cites W2067343115 @default.
- W3118373671 cites W2067576594 @default.
- W3118373671 cites W2068953617 @default.
- W3118373671 cites W2079153314 @default.
- W3118373671 cites W2082273145 @default.
- W3118373671 cites W2082955133 @default.
- W3118373671 cites W2089585948 @default.
- W3118373671 cites W2093230990 @default.
- W3118373671 cites W2097735471 @default.
- W3118373671 cites W2099057097 @default.
- W3118373671 cites W2100582146 @default.
- W3118373671 cites W2101548895 @default.
- W3118373671 cites W2102992903 @default.
- W3118373671 cites W2103544547 @default.
- W3118373671 cites W2103583298 @default.
- W3118373671 cites W2104195793 @default.
- W3118373671 cites W2105247266 @default.
- W3118373671 cites W2105637505 @default.
- W3118373671 cites W2109311268 @default.
- W3118373671 cites W2111063080 @default.
- W3118373671 cites W2111651553 @default.
- W3118373671 cites W2113874231 @default.
- W3118373671 cites W2115888532 @default.